Explanipedia

From acute to chronic: the long-term consequences of AKI in South and Southeast Asia Open

Nicholas M. Selby, Mickaël Bobot · 2025

ECOSBot: a multicenter validation pilot study of a generative AI tool for OSCE-based nephrology training Open

Raphaël Bentegeac, Nans Florens, Mehdi Maanaoui, Valentin Maisons, Antoine Lanot , et al. · 2025

Background Developing diagnostic reasoning in nephrology is particularly challenging due to its pathophysiological complexity and reliance on abstract clinical data. Objective Structured Clinical Examinations (OSCEs) are pivotal for nephro…

Blood-brain barrier permeability in CKD: Link with inflammation and cognitive and mood impairment in rats Open

Mickaël Bobot, Amandine Bruyat, Laurent Thomas, Samantha Fernandez, Alexandre Brodovitch , et al. · 2025

Chronic kidney disease (CKD) is associated with cognitive impairment. CKD is associated with increased permeability of the blood-brain barrier (BBB), resulting in increased cognitive impairment in animals and in humans. The aim of this stu…

C3 Glomerulonephritis Associated With Unusual IgG4 Antifactor H in IgG4-related Disease Open

Paul Dalmas, Mickaël Bobot, Noémie Jourde‐Chiche, Julie Bruno, Stéphane Burtey , et al. · 2025

Kidney Outcomes in Patients With Hereditary Transthyretin Amyloid Nephropathy Treated With Transthyretin Stabilizers And Gene-Silencer Therapies Open

Julien Dang, Justine Solignac, Sophie Ferlicot, Charlotte Mussini, Frank Bridoux , et al. · 2025

Our study highlights the underrecognized risk of chronic kidney disease (CKD) and end-stage kidney disease in ATTRv and suggests that siRNA could be a promising therapeutic option for the stabilization of kidney function.

Diagnostic Value of Biological Parameters in Biopsy-Confirmed Thrombotic Microangiopathy–MATRIX Consortium Group Open

Jean‐Michel Halimi, Anna Duval, Etienne Chardon, Laurent Mesnard, Marie Frimat , et al. · 2025

Common biological parameters miss the diagnosis in more than 50% of TMA except when fibrinogen is < 5 g/l, creatinine ≥ 300 μmol/l, and PT < 90%. Schistocyte reporting is heterogenous, and its results are usually deceptive in TMA.

The role of the intestinal microbiome in cognitive decline in patients with kidney disease Open

Carsten A. Wagner, Isabelle Frey‐Wagner, Alberto Ortíz, Robert J. Unwin, Sophie Liabeuf , et al. · 2025

Cognitive decline is frequently seen in patients with chronic kidney disease (CKD). The causes of cognitive decline in these patients are likely to be multifactorial, including vascular disease, uraemic toxins, blood–brain barrier leakage,…

Cognitive impairment in kidney transplanted patients Open

Jolanta Małyszko, Aleksandra Golenia, Michele Farisco, Vincenzina Lo Re, Aleksandra Klimkowicz‐Mrowiec , et al. · 2025

Chronic kidney disease affects almost all of the organs. Recently, more attention has been paid to the kidney and the central nervous system connections. In patients on kidney replacement therapy, including kidney transplantation, there is…

Care pathways for patients with cognitive impairment and chronic kidney disease Open

Marion Pépin, Konstantinos Giannakou, Hélène Levassort, Ana Farinha, Mickaël Bobot , et al. · 2025

Various epidemiological datasets and pathophysiological hypotheses have highlighted a significant link between chronic kidney disease (CKD) and cognitive impairment (CI); each condition can potentially exacerbate the other. Here, we review…

CONNECT: what has been done and what needs to be done Open

Giovambattista Capasso, Robert J. Unwin, Giovambattista Capasso, Alexandre Andrade, Mustafa Arici , et al. · 2025

Chemotherapy-related cognitive impairment and kidney dysfunction Open

Mariadelina Simeoni, Michele M. Mulholland, Biruh Workeneh, Anna Capasso, Gaye Hafez , et al. · 2025

Cancer and kidney diseases (KD) intersect in many ways resulting in worse outcomes. Both conditions are correlated with cognitive impairment, which can be exacerbated in cancer patients by known effects of many antineoplastic drugs on cogn…

Genetic and circulating biomarkers of cognitive dysfunction and dementia in CKD Open

Carmine Zoccali, Francesca Mallamaci, Carsten A. Wagner, Robert J. Unwin, Maiken Nedergaard , et al. · 2025

Chronic kidney disease (CKD) is commonly accompanied by cognitive dysfunction and dementia, which, in turn, increase the risk of hospitalization, cardiovascular events and death. Over the last 30 years, only four studies focused on genetic…

Big databases and biobanks for studying the links between CKD, cognitive impairment, and dementia Open

Carmine Zoccali, Francesca Mallamaci, Kerry Rosenberg, Robert J. Unwin, Pedro Imenez Silva , et al. · 2025

Research on cognitive function in individuals with chronic kidney disease (CKD) is critical due to the significant public health challenge posed by both CKD and cognitive impairment. CKD affects approximately 10–15% of the adult population…

Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors Open

Alexandre Andrade, Maie Bachmann, Mickaël Bobot, Annette Bruchfeld, Ivo Fridolin , et al. · 2025

Chronic kidney disease is associated with cognitive impairment although the underlying mechanisms are still not fully understood. Characterization and efficient monitoring of the cognitive impact of kidney disease and ensuing therapies are…

Depression in chronic kidney disease: Particularities, specific mechanisms and therapeutic considerations, a narrative review Open

Antoine Lefrère, Stéphane Burtey, Stanislas Bobot, Raoul Belzeaux, Mickaël Bobot · 2025

Cholinergic system in patients with chronic kidney disease: cognitive and renal implications Open

Hong Xu, Maria Eriksdotter, Gaye Hafez, Sumonto Mitra, Annette Bruchfeld , et al. · 2025

Cholinergic synapses are widespread throughout the human central nervous system. Their high density in the thalamus, neocortex, limbic system and striatum suggests that cholinergic transmission plays a vital role in memory, attention, lear…

Thrombotic Microangiopathy From Peptide Receptor Radionuclide Therapy Open

Paul Delalande, Mickaël Bobot, Marie Essig, Corinne Simon, A.‐P. Jonville‐Béra , et al. · 2024

International audience

Comparing Different Methods for the Diagnosis of Liver Steatosis: What Are the Best Diagnostic Tools? Open

Sophie Chopinet, O. Lopez, Sophie Brustlein, Antoine Uzel, Anaïs Moyon , et al. · 2024

Background: Due to the ongoing organ shortage, marginal grafts with steatosis are more frequently used in liver transplantation, leading to higher occurrences of graft dysfunction. A histological analysis is the gold standard for the quant…

Cognitive impairment in CKD patients: a guidance document by the CONNECT network Open

Davide Bolignano, Mariadelina Simeoni, Gaye Hafez, Marion Pépin, Antonio Gallo , et al. · 2024

Cognitive impairment is a prevalent and debilitating complication in patients with chronic kidney disease (CKD). This position paper, developed by the Cognitive Decline in Nephro-Neurology: European Cooperative Target network, provides gui…

Increased Blood-Brain Barrier Permeability and Cognitive Impairment in Patients With ESKD Open

Mickaël Bobot, Éric Guedj, Noémie Resseguier, Julien Faraut, Philippe Garrigue , et al. · 2024

Patients with ESKD display an increased BBB permeability compared to matched healthy volunteers. Association with uremic toxins and cognitive impairment needs to be assessed in larger cohorts of patients.

Immunoadsorption and Plasma Exchange are Comparable in Anti-Neutrophil Cytoplasmic Antibodies or Anti-Glomerular Basement Membrane Removal Kinetics Open

Marion Sallée, Noémie Resseguier, Thomas Crépin, Daniel Bertin, Dominique Bertrand , et al. · 2024

Kidney involvement in myelodysplastic syndromes Open

Marie-Camille Lafargue, Jean‐Paul Duong Van Huyen, Helmut G. Rennke, Marie Essig, Mickaël Bobot , et al. · 2024

Introduction The objective of this study was to describe kidney involvement in patients with myelodysplastic syndromes (MDS), their treatments, and outcomes. Methods We conducted a multicenter retrospective study in seven centers, identify…

Drugs with a negative impact on cognitive functions (part 3): antibacterial agents in patients with chronic kidney disease Open

Sophie Liabeuf, Gaye Hafez, Vesna Pešić, Goce Spasovski, Mickaël Bobot , et al. · 2024

The relationship between chronic kidney disease (CKD) and cognitive function has received increased attention in recent years. Antibacterial agents (ABs) represent a critical component of therapy regimens in patients with CKD due to increa…

Cognitive Impairment Phenotypes in Patients with CKD Stages 3b and 4 Open

Mickaël Bobot, Julie Bruno, Stéphane Burtey · 2024

International audience

How Clot Composition Influences Fibrinolysis in the Acute Phase of Stroke: A Proteomic Study of Cerebral Thrombi Open

Émilie Doche, Constance Sulowski, Jean‐Marie Guigonis, Fanny Graslin, Barbara Casolla , et al. · 2024

BACKGROUND: The dramatic clinical improvement offered by mechanical thrombectomy raised questions about the relevance of prior intravenous thrombolysis in large-vessel occlusion strokes. Hence, studying intravenous thrombolysis susceptibil…

#2088 Renal outcome, cardio-vascular events and infections in patients with lupus nephritis: MassiLUP cohort 2001-2022 Open

Bérangère Goupille, Noémie Resseguier, Julia Torrents, Stanislas Bataille, Mickaël Bobot , et al. · 2024

Background and Aims Most epidemiological studies in lupus nephritis (LN) report the risk of end-stage kidney disease (ESKD) (10-20% of patients at 10-15 years in developed countries), but less data is available on the long-term risk of chr…

#1086 Blood-brain barrier permeability in patients with end-stage kidney disease: results from the BREIN study Open

Mickaël Bobot, Éric Guedj, Noémie Resseguier, Julien Faraut, Philippe Garrigue , et al. · 2024

Background and Aims Chronic kidney disease (CKD) is associated with an increased risk of cognitive impairment. In several models of CKD in rodents, we highlighted that CKD was associated with cognitive impairment and increased blood-brain …

Animal models to study cognitive impairment of chronic kidney disease Open

Pedro Henrique Imenez Silva, Marion Pépin, Andreja Figurek, Eugenio Gutiérrez‐Jiménez, Mickaël Bobot , et al. · 2024

Mild cognitive impairment (MCI) is common in people with chronic kidney disease (CKD), and its prevalence increases with progressive loss of kidney function. MCI is characterized by a decline in cognitive performance greater than expected …

Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey Open

Michele Farisco, Inga A Blumblyte, Casper Franssen, Dorothea Nitsch, Irene Zecchino , et al. · 2024

Background and hypothesis There seems to be a lack of consensus on the necessity and the modality of psychological and specifically cognitive assessment of candidates for kidney transplantation. Both points are often delegated to individua…

Prospective Multicenter Study on Early Proximal Tubular Injury in COVID-19–Related Acute Respiratory Distress Syndrome Open

Mickaël Bobot, Xavier Heim, Howard Max, José Boucraut, Pierre Simeone , et al. · 2024

Patients with COVID-19-related ARDS display a proximal tubular dysfunction before the onset of AKI, which predicts AKI. Proximal tubular damage seems an important mechanism of COVID-19-induced nephropathy. Analysis of urinary proteins is a…

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