Mickaël Costallat
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View article: Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis Open
HP1α/CBX5 is an epigenetic regulator with a suspected role in multiple sclerosis (MS). Here, using high-depth RNA sequencing on monocytes, we identified a subset of MS patients with reduced CBX5 expression, correlating with progressive sta…
View article: Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosis Open
HP1α/CBX5 is an epigenetic regulator with a suspected role in multiple sclerosis (MS). Here, using high-depth RNA sequencing on monocytes, we identified a subset of MS patients with reduced CBX5 expression, correlating with progressive sta…
View article: The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis
The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis Open
View article: The ‘Alu-ome’ shapes the epigenetic environment of regulatory elements controlling cellular defense
The ‘Alu-ome’ shapes the epigenetic environment of regulatory elements controlling cellular defense Open
Promoters and enhancers are sites of transcription initiation (TSSs) and carry specific histone modifications, including H3K4me1, H3K4me3, and H3K27ac. Yet, the principles governing the boundaries of such regulatory elements are still poor…
View article: Influenza A virus RNA Polymerase targets the chromatin of innate immune response genes
Influenza A virus RNA Polymerase targets the chromatin of innate immune response genes Open
The influenza A virus (IAV) RNA polymerase (FluPol) primes the viral transcription by using capped 5 prime-ends snatched from host nascent RNAs. However, the exact localization of the FluPol on the genome or the timing of its snatching act…
View article: The “Alu-ome” shapes the epigenetic environment of regulatory elements controlling cellular defense
The “Alu-ome” shapes the epigenetic environment of regulatory elements controlling cellular defense Open
Promoters and enhancers are sites of transcription initiation (TSSs) and carry active histone modifications, including H3K4me1, H3K4me3, and H3K27ac. Yet, the principles governing the boundaries of such regulatory elements are still poorly…
View article: HP1γ binding pre‐mRNA intronic repeats modulates RNA splicing decisions
HP1γ binding pre‐mRNA intronic repeats modulates RNA splicing decisions Open
View article: Reduced RNA turnover as a driver of cellular senescence
Reduced RNA turnover as a driver of cellular senescence Open
Accumulation of senescent cells is an important contributor to chronic inflammation upon aging. The inflammatory phenotype of senescent cells was previously shown to be driven by cytoplasmic DNA. Here, we propose that cytoplasmic double-st…
View article: The Heterochromatin protein 1 is a master regulator in RNA splicing precision deficient in ulcerative colitis
The Heterochromatin protein 1 is a master regulator in RNA splicing precision deficient in ulcerative colitis Open
Defects in RNA splicing have been linked to numerous human disorders, but remain poorly explored in inflammatory bowel disease (IBD). Here, we report that, in the gut epithelium of patients with ulcerative colitis (UC), the expression of t…
View article: Reduced RNA turnover as a driver of cellular senescence
Reduced RNA turnover as a driver of cellular senescence Open
Accumulation of senescent cells is an important contributor to chronic inflammation upon aging. While cytoplasmic DNA was shown to drive the inflammatory phenotype of senescent cells, an equivalent role for RNA has never been explored. Her…
View article: HP1γ binding pre-mRNA at intronic repeats increases splicing fidelity and regulates alternative exon usage
HP1γ binding pre-mRNA at intronic repeats increases splicing fidelity and regulates alternative exon usage Open
HP1 proteins are best known as markers of heterochromatin and gene silencing. Yet, they are also RNA-binding proteins and the HP1γ/Cbx3 family member is present on transcribed genes together with RNA polymerase II, where it regulates co-tr…