Explanipedia

Response to “high-flow nasal cannula and intubation risk in severe PjP: methodological and clinical perspectives” Open

Nahéma Issa, Benjamin Gaborit, Charlotte Biron, R. Lecomte, Romain Lécuyer , et al. · 2025

Cost-utility of point-of-care viscoelastic hemostatic assays in the management of bleeding during cardiac surgery: a single-blinded prospective multicenter stepped wedge cluster randomized trial in French context Open

Mickaël Vourc’h, Karim Lakhal, Véronique Wurtz, Diane Zlotnik, Antoine Beurton , et al. · 2025

Clinical trial submission: November 2, 2016 Registry name: Cost-Utility Analysis of Management of Peri Operative Hemorrhage Following Cardiac Surgery With Cardiopulmonary Bypass (IMOTEC) ClinicalTrials.gov Identifier: NCT02972684 URL regis…

Cost-revenue analysis of using a haemoadsorbent membrane in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass and ticagrelor Open

Benjamin Mathat, Yves Daniel Compaoré, Charles‐Henri David, Valéry-Pierre Riche, Mark L. Ryan , et al. · 2025

In the French financial context, the use of the Cytosorb® in coronary artery bypass graft surgery with ticagrelor leads to additional costs, despite a slight revenue increase and the potential benefit of a shorter stay in the intensive car…

Respiratory management of critically ill pneumocystis pneumonia patients: a multicenter retrospective study Open

Florian Reizine, V. Stiegler, Romain Lécuyer, Benoît Tessoulin, Monique Gallais , et al. · 2025

Background Pneumocystis jirovecii pneumonia (PjP) is a rising cause of acute respiratory failure in immunocompromised patients, often requiring Intensive Care Unit (ICU) admission. However, optimal ventilatory strategies remain unclear. Me…

Intubation of obese patients in the operating room with or without bag-mask ventilation: study protocol for a randomized multicenter trial (VENT OR NOT) Open

Souhaïl Znaïdi, Romain Deransy, Karim Asehnoune, Marguerite Le Penndu, Bertrand Rozec , et al. · 2025

Background Almost two-thirds of the adults in Europe are overweight or obese. Obese patients are at higher risk of complications, especially during intubation. Therefore, the management of general anesthesia is crucial. Regarding intubatio…

Optimization of cerebral oxygenation based on regional cerebral oxygen saturation monitoring during carotid endarterectomy: a Phase III multicenter, double-blind randomized controlled trial Open

Y. Le Teurnier, Bertrand Rozec, C. Degryse, François Lévy, Youcef Miliani , et al. · 2024

ClinicalTrials.gov identifier: NCT01415648.

Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study Open

Nicolas Nesseler, Alexandre Mansour, Matthieu Schmidt, Marylou Para, Alizée Porto , et al. · 2024

High-flow oxygen therapy versus facemask preoxygenation in anticipated difficult airway management (PREOPTI-DAM): an open-label, single-centre, randomised controlled phase 3 trial Open

Mickaël Vourc’h, Donatien Huard, Marguerite Le Penndu, Romain Deransy, Marielle Surbled , et al. · 2023

Nantes University Hospital and Fisher & Paykel Healthcare.

BRIGHT-4 trial: bivalirudin strikes back Open

Pierre‐Guillaume Piriou, Thibaut Manigold, Vincent Letocart, Patrice Guérin, Mickaël Vourc’h · 2023

Dossier de Titres et Travaux pour l’obtention du diplôme d’Habilitation à Diriger les Recherches Open

Mickaël Vourc’h · 2022

Transfusion-Related Renal Dysfunction After Cardiac Surgery Open

Mickaël Vourc’h, Antoine Roquilly, Adrien Foucher, Christelle Retière, Fanny Feuillet , et al. · 2022

Transfusion is a specific cause of acute kidney injury (AKI) after cardiac surgery. Whether there is an association between the composition of blood products and the onset of AKI is unknown. The present study suggests that the transfusion …

Potential Impact of Rapid Multiplex PCR on Antimicrobial Therapy Guidance for Ventilated Hospital-Acquired Pneumonia in Critically Ill Patients, A Prospective Observational Clinical and Economic Study Open

Florian Guillotin, Cécile Poulain, Benjamin Gaborit, Marwan Bouras, Raphaël Cinotti , et al. · 2022

Objectives To investigate the potential impact of the syndromic multiplex FilmArray ® Pneumonia plus Panel (FAPP) on the antimicrobial treatment guidance of patients with ventilated hospital-acquired pneumonia (VHAP). Methods Respiratory f…

Prevalence, Characteristics, and Outcomes of COVID-19–Associated Acute Myocarditis Open

Enrico Ammirati, Laura Lupi, Matteo Palazzini, Nicholas Hendren, Justin L. Grodin , et al. · 2022

Background: Acute myocarditis (AM) is thought to be a rare cardiovascular complication of COVID-19, although minimal data are available beyond case reports. We aim to report the prevalence, baseline characteristics, in-hospital management,…

Effect of Moderate Hypothermia vs Normothermia on 30-Day Mortality in Patients With Cardiogenic Shock Receiving Venoarterial Extracorporeal Membrane Oxygenation Open

Bruno Lévy, Nicolas Girerd, Julien Amour, Emmanuel Besnier, Nicolas Nesseler , et al. · 2022

Importance The optimal approach to the use of venoarterial extracorporeal membrane oxygenation (ECMO) during cardiogenic shock is uncertain. Objective To determine whether early use of moderate hypothermia (33-34 °C) compared with strict n…

Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury Open

Antoine Roquilly, Jean-Denis Moyer, Olivier Huet, Sigismond Lasocki, Benjamin L. Cohen , et al. · 2021

ClinicalTrials.gov Identifier: NCT03143751.

Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation Open

Mickaël Vourc’h, Charlotte Garret, Arnaud Gacouin, Jean-Claude Lachérade, Maud Jonas , et al. · 2021

ClinicalTrials.gov Identifier: NCT02723383.

Pseudomonas aeruginosa Infection Impairs NKG2D-Dependent NK Cell Cytotoxicity through Regulatory T-Cell Activation Open

Mickaël Vourc’h, Gaëlle David, Benjamin Gaborit, Alexis Broquet, Cédric Jacqueline , et al. · 2020

Natural killer (NK) cells play a key role in both antibacterial and antitumor immunity. Pseudomonas aeruginosa infection has already been reported to alter NK cell functions. We studied in vitro the effect of P. aeruginosa on NK cell cytot…

Cost of red blood cell transfusion; evaluation in a French academic hospital Open

Jean‐Christophe Rigal, V.P. Riche, Martine Tching-Sin, Clémentine Fronteau, Jean‐François Huon , et al. · 2020

Author Correction: Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis Open

Antoine Roquilly, Cédric Jacqueline, Marion Davieau, Alice Mollé, Abderrahmane Sadek , et al. · 2020

Haemolysis index: validation for haemolysis detection during extracorporeal membrane oxygenation Open

Elodie Boissier, Karim Lakhal, Thomas Sénage, Philippe Bizouarn, Thierry Lepoivre , et al. · 2020

Impact of Alcohol Use Disorder and Agitation-related Adverse Events on Patient’s Outcome in the ICU and the Following One Year after Admission Open

Mickaël Vourc’h · 2020

Aims: Unhealthy alcohol use increases morbidity and agitation in the Intensive Care Units (ICU).The consequences of agitation on patients 'outcome has not been investigated so far.Methods: Impact OH is a prospective observational monoester…

Interleukin-22 regulates interferon lambda expression in a mice model of pseudomonas aeruginosa pneumonia Open

Alexis Broquet, Anissa Besbes, Jérôme C. Martin, Cédric Jacqueline, Mickaël Vourc’h , et al. · 2019

Cortisol total/CRP ratio for the prediction of hospital-acquired pneumonia and initiation of corticosteroid therapy in traumatic brain-injured patients Open

Marwan Bouras, Antoine Roquilly, Pierre-Joachim Mahé, Raphaël Cinotti, Mickaël Vourc’h , et al. · 2019

Pharmacokinetic data on high dose baclofen administration in unhealthy alcohol user in the ICU Open

Mickaël Vourc’h, Éric Dailly, Yannick Hourmant, Ronan Bellouard, Pierre-Joachim Mahé , et al. · 2019

Alterations of the iNKT cell compartment in brain-injured patients Open

Allan Patinec, Jézabel Rocher, Mickaël Vourc’h, Antoine Roquilly, Karim Asehnoune , et al. · 2019

High-flow Nasal Cannulae Versus Non-invasive Ventilation for Preoxygenation of Obese Patients: The PREOPTIPOP Randomized Trial Open

Mickaël Vourc’h, Gabrielle Baud, Fanny Feuillet, Claire Blanchard, Éric Mirallié , et al. · 2019

Preoxygenation in difficult airway management: high-flow oxygenation by nasal cannula versus face mask (the PREOPTIDAM study). Protocol for a single-centre randomised study Open

Mickaël Vourc’h, Donatien Huard, Fanny Feuillet, Gabrielle Baud, Arthur Guichoux , et al. · 2019

Introduction Although preoxygenation and airway management respond to precise algorithms, difficult intubation (DI) remains a daily challenge in intensive care units and in the operating rooms because of its frequent complications, includi…

Nasal high-flow preoxygenation for endotracheal intubation in the critically ill patient: a randomized clinical trial Open

Christophe Guitton, Stéphan Ehrmann, Christelle Volteau, Gwenhaël Colin, Adel Maamar , et al. · 2019

Preoxygenation in Obese Patients: High-Flow Nasal Cannula Oxygen Versus Non-Invasive Ventilation: A Randomised Controlled Study. The PREOPTIPOP Study Open

Mickaël Vourc’h, Gabrielle Baud, Fanny Feuillet, Claire Blanchard, Éric Mirallié , et al. · 2019

Population pharmacokinetics of daptomycin in critically ill patients with various degrees of renal impairment Open

Nicolas Grégoire, Sandrine Marchand, Martine Ferrandière, Sigismond Lasocki, Philippe Séguin , et al. · 2018

Daptomycin at 10 mg/kg q24h allowed efficacy pharmacokinetic/pharmacodynamic targets for ICU patients with CLCR ≥30 mL/min to be reached. For patients with CLCR <30 mL/min, halving the rate of drug administration, i.e. 10 mg/kg q48h, was s…

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