Micky D. Tortorella
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View article: Cryo-EM structure of TMEM164 reveals distinct phospholipid remodeling mechanisms with anti-ferroptotic potential
Cryo-EM structure of TMEM164 reveals distinct phospholipid remodeling mechanisms with anti-ferroptotic potential Open
Phospholipids in cell membrane provide both regulatory and structural function of a cell. How lipid remodeling regulates cell fate remains less explored. Here we report the cryo-electron microscopy structure of TMEM164 identified by genome…
View article: Staphylococcal enterotoxin C2 rescued simulated microgravity-induced bone loss and the trans-differentiation of BMSCs into adipocytes
Staphylococcal enterotoxin C2 rescued simulated microgravity-induced bone loss and the trans-differentiation of BMSCs into adipocytes Open
Exposure to microgravity decreases bone volume and increases marrow fat, partly due to impaired BMSC osteogenesis and enhanced adipogenesis. Staphylococcal enterotoxin C2 (SEC2) can influence BMSC differentiation, potentially promoting ost…
View article: DHA laden liposome incorporated HA-menthol-CD host-guest hydrogels as delivery system for osteoarthritis treatment
DHA laden liposome incorporated HA-menthol-CD host-guest hydrogels as delivery system for osteoarthritis treatment Open
The immobilization of liposomes together laden drugs in the hydrogel matrix network has proven to be an effective technique for protecting them against rapid clearance in the body. This allows for localized and controlled drug delivery ove…
View article: MiR-378 mediates the ovariectomy induced bone loss via exaggerating osteoclastogenesis and transforming growth factor beta impaired osteogenesis
MiR-378 mediates the ovariectomy induced bone loss via exaggerating osteoclastogenesis and transforming growth factor beta impaired osteogenesis Open
Osteoporosis (OP) is a disease characterized by decreased bone mass and damaged architectures. The promising treatment strategy for OP is to inhibit bone resorption while promoting bone formation. MicroRNAs (miRNAs) have been shown to be a…
View article: The Differential Effects of Genetic Mutations in ALS and FTD Genes on Behavioural and Cognitive Changes: A Systematic Review and Meta-Analysis
The Differential Effects of Genetic Mutations in ALS and FTD Genes on Behavioural and Cognitive Changes: A Systematic Review and Meta-Analysis Open
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are linked by shared genetic mutations and overlapping clinical features, forming a clinical spectrum. This systematic review and meta-analysis analysed 97 studies, incl…
View article: Discovery of novel fluorescent amino-pyrazolines that detect and kill Mycobacterium tuberculosis
Discovery of novel fluorescent amino-pyrazolines that detect and kill Mycobacterium tuberculosis Open
The emergence of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) necessitates novel therapeutics with distinct mechanisms. Here, we report amino-pyrazoline derivatives as a new class of dual-functional antimycobacterial agents, int…
View article: A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats
A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats Open
TBI (traumatic brain injury) is a major cause of mortality and morbidity among young adults with limited therapeutic strategies. Cranial bone transport (CBT) technique is a safe, less invasive, and relatively simple surgical technique in b…
View article: Synthesis of β‐fluoropyrrolidines Designed to Reduce hERG Affinity in a Class of Antiparasitic Compounds
Synthesis of β‐fluoropyrrolidines Designed to Reduce hERG Affinity in a Class of Antiparasitic Compounds Open
Malaria is a parasitic disease caused by the parasite Plasmodium which results in hundreds of thousands of deaths per year. The need for new drugs for the treatment of this disease is imperative as new resistant strains of Plasmodium emerg…
View article: Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function
Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function Open
INTRODUCTION Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their…
View article: EPIDetect: Video-based convulsive seizure detection in chronic epilepsy mouse model for anti-epilepsy drug screening
EPIDetect: Video-based convulsive seizure detection in chronic epilepsy mouse model for anti-epilepsy drug screening Open
In the preclinical translational studies, drug candidates with remarkable anti-epileptic efficacy demonstrate long-term suppression of spontaneous recurrent seizures (SRSs), particularly convulsive seizures (CSs), in mouse models of chroni…
View article: Azetidines Kill Multidrug-Resistant <i>Mycobacterium tuberculosis</i> without Detectable Resistance by Blocking Mycolate Assembly
Azetidines Kill Multidrug-Resistant <i>Mycobacterium tuberculosis</i> without Detectable Resistance by Blocking Mycolate Assembly Open
Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10.6 million new cases and 1.4 million deaths in 2021. This global emergency is exacerbated by the emergence of multidrug…
View article: Entorhinohippocampal cholecystokinin modulates spatial learning by facilitating neuroplasticity of hippocampal CA3-CA1 synapses
Entorhinohippocampal cholecystokinin modulates spatial learning by facilitating neuroplasticity of hippocampal CA3-CA1 synapses Open
The hippocampus is broadly impacted by neuromodulations. However, how neuropeptides shape the function of the hippocampus and the related spatial learning and memory remains unclear. Here, we discover the crucial role of cholecystokinin (C…
View article: Cholecystokinin B Receptor Agonists Alleviates Anterograde Amnesia in CCK-deficient and Aged Alzheimer's Disease Mice
Cholecystokinin B Receptor Agonists Alleviates Anterograde Amnesia in CCK-deficient and Aged Alzheimer's Disease Mice Open
Background As one major symptom of Alzheimer’s disease (AD), anterograde amnesia describes patients with an inability in new memory formation. The crucial role of the entorhinal cortex in forming new memories has been well established, and…
View article: Low‐Dose Staphylococcal Enterotoxin C2 Mutant Maintains Bone Homeostasis via Regulating Crosstalk between Bone Formation and Host T‐Cell Effector Immunity
Low‐Dose Staphylococcal Enterotoxin C2 Mutant Maintains Bone Homeostasis via Regulating Crosstalk between Bone Formation and Host T‐Cell Effector Immunity Open
Studies in recent years have highlighted an elaborate crosstalk between T cells and bone cells, suggesting that T cells may be alternative therapeutic targets for the maintenance of bone homeostasis. Here, it is reported that systemic admi…
View article: Long Non-Coding RNA Malat1 Increases the Rescuing Effect of Quercetin on TNFα-Impaired Bone Marrow Stem Cell Osteogenesis and Ovariectomy-Induced Osteoporosis
Long Non-Coding RNA Malat1 Increases the Rescuing Effect of Quercetin on TNFα-Impaired Bone Marrow Stem Cell Osteogenesis and Ovariectomy-Induced Osteoporosis Open
Osteoporosis, a common systematic bone homeostasis disorder related disease, still urgently needs innovative treatment methods. Several natural small molecules were found to be effective therapeutics in osteoporosis. In the present study, …
View article: A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition
A Novel CCK Receptor GPR173 Mediates Potentiation of GABAergic Inhibition Open
Cholecystokinin (CCK) enables excitatory circuit long-term potentiation (LTP). Here, we investigated its involvement in the enhancement of inhibitory synapses. Activation of GABA neurons suppressed neuronal responses in the neocortex to a …
View article: Cartilage organoids for cartilage development and cartilage-associated disease modeling
Cartilage organoids for cartilage development and cartilage-associated disease modeling Open
Cartilage organoids have emerged as powerful modelling technology for recapitulation of joint embryonic events, and cartilage regeneration, as well as pathophysiology of cartilage-associated diseases. Recent breakthroughs have uncovered “m…
View article: Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat‐shock protein family
Human fetal mesenchymal stem cells secretome promotes scarless diabetic wound healing through heat‐shock protein family Open
The high mortality rate of patients with diabetic foot ulcers is urging the appearance of an effective biomedical drug. Senescence is one of the major reasons of aging‐induced decline in the diabetic wound. Our previous studies have demons…
View article: Design and biological evaluation of substituted 5,7-dihydro-6 <i>H</i> -indolo[2,3- <i>c</i> ]quinolin-6-one as novel selective Haspin inhibitors
Design and biological evaluation of substituted 5,7-dihydro-6 <i>H</i> -indolo[2,3- <i>c</i> ]quinolin-6-one as novel selective Haspin inhibitors Open
A library of substituted indolo[2,3-c]quinolone-6-ones was developed as simplified Lamellarin isosters. Synthesis was achieved from indole after a four-step pathway sequence involving iodination, a Suzuki-Miyaura cross-coupling reaction, a…
View article: Sesamin Promotes Osteoporotic Fracture Healing by Activating Chondrogenesis and Angiogenesis Pathways
Sesamin Promotes Osteoporotic Fracture Healing by Activating Chondrogenesis and Angiogenesis Pathways Open
Osteoporotic fracture has been regarded as one of the most common bone disorders in the aging society. The natural herb-derived small molecules were revealed as potential treatment approaches for osteoporotic fracture healing. Sesamin is a…
View article: Small Molecule Inhibitors of Programmed Cell Death Ligand 1 (PD-L1): A Patent Review (2019–2021)
Small Molecule Inhibitors of Programmed Cell Death Ligand 1 (PD-L1): A Patent Review (2019–2021) Open
Compared with mAbs, PD-1/PD-L1 small-molecule inhibitors show several advantages such as improved tissue penetration, low immunogenicity, well-understood formulation and lower manufacturing costs. They can serve as complementary or synergi…