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View article: Evaluation of the association of some circulating miRNA molecules in the metabolic syndrome
Evaluation of the association of some circulating miRNA molecules in the metabolic syndrome Open
Purpose: The aim of this study was to investigate the possibility of including miRNA-371 and miRNA-143 in the early detection and diagnosis of the extent of the metabolic syndrome (MetS) in obese patients by measuring the expression of miR…
View article: Green Synthesis of Zinc oxide Nanocomposite Using Fusarium oxysporum and Evaluation of the Anticancer Effect on Hepatocellular Carcinoma
Green Synthesis of Zinc oxide Nanocomposite Using Fusarium oxysporum and Evaluation of the Anticancer Effect on Hepatocellular Carcinoma Open
Nanoparticles can be synthesized by chemical, physical and biological system methods. In this work, Superparamagnetic Iron Oxide@Silver nanoparticles (SPION@Ag NPs) were modified by zinc oxide nanoparticles (ZnO NPs). SPION@Ag core shell N…
View article: Genomic Association Between Angiotensin-Converting Enzyme, Angiotensinogen And ARNT-Like Protein-1Genes With Susceptibility To Gestational Diabetes In Egyptian Women
Genomic Association Between Angiotensin-Converting Enzyme, Angiotensinogen And ARNT-Like Protein-1Genes With Susceptibility To Gestational Diabetes In Egyptian Women Open
Background and aims: Gestational diabetes mellitus (GDM) is well-defined as glucose intolerance first documented during pregnancy. In the present study, we examined the possible associations between I/D polymorphism of the angiotensin-conv…
View article: Antidiabetic effects of curcumin/zinc oxide nanocomposite in streptozotocin-induced diabetic rats
Antidiabetic effects of curcumin/zinc oxide nanocomposite in streptozotocin-induced diabetic rats Open
Diabetes mellitus (DM) is a tremendously widespread endocrine disease that causes many complications risking patient’s quality of life. The current study aims to evaluate the antidiabetic potential of curcumin nanoparticles (Curc-NPs), Zin…
View article: Modafinil Alleviates Rotenone-Induced Neurochemical changes and Striatal Neurodegeneration via Inhibiting Oxidative Stress and Neuroinflammation
Modafinil Alleviates Rotenone-Induced Neurochemical changes and Striatal Neurodegeneration via Inhibiting Oxidative Stress and Neuroinflammation Open
Objectives of study are around investigation the effect of the central nervous system stimulant modafinil on brain striatum neurodegeneration caused by subcutaneous (s.c.) rotenone administration in rats, further, the possible modulation b…
View article: Evaluation of Zinc-oxide Nanoparticles effect on treatment of diabetes in streptozotocin-induced diabetic rats
Evaluation of Zinc-oxide Nanoparticles effect on treatment of diabetes in streptozotocin-induced diabetic rats Open
T O produce unique products with novel properties, to manipulate materials at the nano- scale level.Nanoparticles demonstrate novel or improved characteristics that are supported with specific properties such as size and distribution.The e…
View article: Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus
Evaluation of pro-inflammatory and anti-inflammatory cytokines in type 1 diabetes mellitus Open
Background Type 1 diabetes mellitus (T1DM) is a chronic inflammatory disease concerning insulin-producing β-cells destroyed by the conjoined action of auto reactive T cells, inflammatory cytokines and monocytic cells. Recent proof favors c…
View article: Alterations of Tumor Suppressor Genes Expression in Colorectal Cancer: Their Impact on Progression and Prediction of Patients Outcome
Alterations of Tumor Suppressor Genes Expression in Colorectal Cancer: Their Impact on Progression and Prediction of Patients Outcome Open
Background: Deregulation of tumor suppressor genes as APC, DCC and SMAD2 are related to tumorgenesis thus we aimed to investigate their expression among colorectal cancer to validate their relation with clinicopathological factors and the …
View article: Assessment of Ki-67 as a potential biomarker in patients with breast cancer
Assessment of Ki-67 as a potential biomarker in patients with breast cancer Open
Breast cancer is the most common cancer in females, it accounts for one third of all malignancies affecting women. Appropriate biomarkers play significant role in predicting the prognosis and decide the specific therapy to each patient. In…
View article: Relationship between Sex Hormone-Binding Globulin (SHBG) and Insulin-Like Growth Factor-I (IGF-I) with Metabolic Syndrome
Relationship between Sex Hormone-Binding Globulin (SHBG) and Insulin-Like Growth Factor-I (IGF-I) with Metabolic Syndrome Open
G LUCOSE intolerance, insulin resistance, hypertension, visceral obesity, and dyslipidemia are the major components of metabolic syndrome (MS).To evaluate the association between serum SHBG and IGF-1 levels and the risk of MS, Furthermore,…
View article: The Combined Effect of ACE, TCF7L2, and PPARGC1A Gene Polymorphisms in Diabetic Nephropathy
The Combined Effect of ACE, TCF7L2, and PPARGC1A Gene Polymorphisms in Diabetic Nephropathy Open
Diabetic nephropathy (DN), Type 2 diabetes mellitus (T2DM), Angiotensinconverting enzyme (ACE), Transcription factor 7-like 2 (TCF7L2), Peroxisome proliferator activated receptor gamma coactivator-1 alpha (PPARGC1A). 62T HIS study was perf…
View article: Evaluation of Biomarkers in Egyptian Patients with Different Grades of Nonalcoholic Fatty Liver Disease
Evaluation of Biomarkers in Egyptian Patients with Different Grades of Nonalcoholic Fatty Liver Disease Open
Background and Aims: Nonalcoholic fatty liver disease (NAFLD) is a silent disease; its spectrum includes simple steatosis, nonalcoholic steatohepatitis and fibrosis. Pro- and anti-inflammatory cytokines play roles in the pathogenesis of NA…
View article: Evaluation of serum soluble E-selectin in breast cancer
Evaluation of serum soluble E-selectin in breast cancer Open
Organic Arsenical Exposure Stimulates Atherosclerosis through Oxidative Stress Increase and Adhesion Molecule Expression Afeez Adekunle Ishola, Norlelawati A.Talib, Naznin Muhammad, Zunariah Buyong, Abdul Hadi Mohamed, Yiyi Myint, Niza Sam…
View article: Relation between microRNAs and Apoptosis in Hepatocellular Carcinoma
Relation between microRNAs and Apoptosis in Hepatocellular Carcinoma Open
AIM: To determine the relation between serum microRNAs and apoptotic markers as regards development of HCC to understand the underlying mechanism of HCV related hepatocarcinogenesis. PATIENTS AND METHODS: A total of 65 serum samples (25 sa…