Mifflin-Rae Calveron
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View article: 17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma
17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma Open
Rationale: The strongest genetic risk factor for childhood-onset asthma, the 17q21 locus, is associated with increased viral susceptibility and disease-promoting processes.Objectives: To identify biological targets underlying…
View article: Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort
Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort Open
View article: IgA<sup>+</sup>memory B-cells are significantly increased in patients with asthma and small airway dysfunction
IgA<sup>+</sup>memory B-cells are significantly increased in patients with asthma and small airway dysfunction Open
Background Comprehensive studies investigated the role of T-cells in asthma which led to personalised treatment options targeting severe eosinophilic asthma. However, little is known about the contribution of B-cells to this chronic inflam…
View article: T2-high asthma phenotypes across lifespan
T2-high asthma phenotypes across lifespan Open
Rationale In adults, personalised asthma treatment targets patients with type 2 (T2)-high and eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in children. Objectives To define T2-high asthma with eas…