Miguel A. B. Mercado
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View article: The roles of TGFb signaling in CD4 T cell responses to Chlamydia infection in the female reproductive tract 9284
The roles of TGFb signaling in CD4 T cell responses to Chlamydia infection in the female reproductive tract 9284 Open
Description CD4 T cells are essential for host immunity to the intracellular bacterium Chlamydia, and the formation of tissue-resident memory CD4 T cells (CD4 TRM) in the female reproductive tract (FRT) is key for vaccine-induced protectiv…
View article: BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia
BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia Open
The protein basic helix-loop-helix family member e40 (BHLHE40) is a transcription factor recently emerged as a key regulator of host immunity to infections, autoimmune diseases and cancer. In this study, we investigated the role of Bhlhe40…
View article: BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against<i>Chlamydia</i>
BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against<i>Chlamydia</i> Open
The protein basic helix-loop-helix family member e40 (BHLHE40) is a transcription factor recently emerged as a key regulator of host immunity to infections, autoimmune diseases and cancer. In this study, we investigated the role of Bhlhe40…
View article: Transcription factor Bhlhe40 plays a protective role during intravaginal <i>Chlamydia muridarum</i> infection in mice
Transcription factor Bhlhe40 plays a protective role during intravaginal <i>Chlamydia muridarum</i> infection in mice Open
The protein basic helix-loop-helix family member e40 (BHLHE40) is a transcription factor involved in cell cycle regulation and differentiation. It has recently emerged as a key player in immunity regulating T cell responses and cytokine pr…
View article: IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections
IFNγ and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections Open
CD4 T cell-dependent IFNγ production and antibody are the two best known effectors for protective immunity against Chlamydia female reproductive tract (FRT) infection. Nevertheless, mice lacking either IFNγ or B cells can clear the vast ma…
View article: IFNγ and antibody synergize to enhance protective immunity against<i>Chlamydia</i>dissemination and female reproductive tract reinfections
IFNγ and antibody synergize to enhance protective immunity against<i>Chlamydia</i>dissemination and female reproductive tract reinfections Open
CD4 T cell-dependent IFNγ production and antibody are the two best known effectors for protective immunity against Chlamydia female reproductive tract (FRT) infection. Nevertheless, mice lacking either IFNγ or B cells are capable of cleari…
View article: Innate IFN-γ Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-γ Production Is Highly Redundant in the Female Reproductive Tract
Innate IFN-γ Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-γ Production Is Highly Redundant in the Female Reproductive Tract Open
Protective immunity against the obligate intracellular bacterium Chlamydia has long been thought to rely on CD4 T cell-dependent gamma interferon (IFN-γ) production. Nevertheless, whether IFN-γ is produced by other cellular sources during …
View article: Innate IFNγ is essential for systemic<i>Chlamydia</i>control while CD4 T cell-dependent IFNγ production is highly redundant in the female reproductive tract
Innate IFNγ is essential for systemic<i>Chlamydia</i>control while CD4 T cell-dependent IFNγ production is highly redundant in the female reproductive tract Open
Protective immunity to the obligate intracellular bacterium Chlamydia is thought to rely on CD4 T cell-dependent IFNγ production. Nevertheless, whether IFNγ is produced by other cellular source during Chlamydia infection and how CD4 T cell…
View article: Antibody, but not B‐cell–dependent antigen presentation, plays an essential role in preventing <i>Chlamydia</i> systemic dissemination in mice
Antibody, but not B‐cell–dependent antigen presentation, plays an essential role in preventing <i>Chlamydia</i> systemic dissemination in mice Open
The obligate intracellular bacterium Chlamydia trachomatis causes the most prevalent bacterial sexually transmitted infection worldwide. CD4 T cells play a central role in the protective immunity against Chlamydia female reproductive tract…