José Miguel Cisneros
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View article: Fluorescence-based biosensors for West Nile virus detection
Fluorescence-based biosensors for West Nile virus detection Open
Flaviviruses are emerging pathogens, mostly transmitted by arthropod vectors, responsible for human, animal, and zoonotic diseases. The emergence of flaviviruses has been favored in recent decades by factors related to climate change and g…
View article: Development of a Comprehensive Program for the Early Diagnosis and Treatment of Severe Infections in a Tertiary Hospital in Spain
Development of a Comprehensive Program for the Early Diagnosis and Treatment of Severe Infections in a Tertiary Hospital in Spain Open
Background To assess the impact of the rapid diagnosis and treatment of severe infections (rDTSI) program on diagnostic and clinical outcomes in patients with severe infections. Method We conducted a pre–post quasi-experimental study evalu…
View article: Factors associated with SARS-CoV-2 RNAemia development at COVID-19 diagnosis
Factors associated with SARS-CoV-2 RNAemia development at COVID-19 diagnosis Open
Objectives SARS-CoV-2 RNAemia at diagnosis is associated with mortality. The aims were to identify factors associated with the development of RNAemia. Methods Multicenter COVID-19 cohort study was conducted between January 2020 and May 202…
View article: Efficacy of imipenem combined with dimercaptosuccinic acid in a murine sepsis model using Pseudomonas aeruginosa
Efficacy of imipenem combined with dimercaptosuccinic acid in a murine sepsis model using Pseudomonas aeruginosa Open
Infection with metallo β-lactamase (MBL)-producing Pseudomonas aeruginosa poses a global health challenge due to its multidrug resistance and the paucity of available antibiotic therapies. Because MBL-producing P. aeruginosa requires zinc …
View article: ColorPhAST: a visual rapid colorimetric assay for detecting phage-susceptibility in Escherichia coli
ColorPhAST: a visual rapid colorimetric assay for detecting phage-susceptibility in Escherichia coli Open
The alarming increase in the prevalence of multidrug-resistant microorganisms, which in some cases has left no available treatment options, has led to a renewed interest in previously abandoned therapeutic approaches such as bacteriophage …
View article: Aztreonam–avibactam for the treatment of serious infections caused by metallo-β-lactamase-producing Gram-negative pathogens: a Phase 3 randomized trial (ASSEMBLE)
Aztreonam–avibactam for the treatment of serious infections caused by metallo-β-lactamase-producing Gram-negative pathogens: a Phase 3 randomized trial (ASSEMBLE) Open
Background The Phase 3 ASSEMBLE study investigated aztreonam–avibactam versus best available therapy (BAT) for treatment of complicated intra-abdominal infection (cIAI), complicated urinary tract infection (cUTI), hospital-acquired/ventila…
View article: Effectiveness and safety of strategies to optimise antimicrobial use in solid organ transplant recipients. Systematic review and meta-analyses
Effectiveness and safety of strategies to optimise antimicrobial use in solid organ transplant recipients. Systematic review and meta-analyses Open
This study was supported by the Instituto de Salud Carlos III (ISCIII, reference ICI21/00075) and the Centro de Investigación Biomédica en de Enfermedades Infecciosas (CIBERINFEC, CB21/13/00006), ISCIII, Ministerio de Ciencia e Innovación.
View article: Maraviroc treatment for hospitalized participants with non-severe COVID-19 at risk of progression: a randomized, proof-of-concept clinical trial
Maraviroc treatment for hospitalized participants with non-severe COVID-19 at risk of progression: a randomized, proof-of-concept clinical trial Open
We observed a beneficial role of maraviroc in hospitalized participants with mild COVID-19 at risk of progression at admission.
Outcomes of a paediatric antimicrobial stewardship program in the Emergency Department observation unit of a hospital in Spain Open
The implementation of ASP measures improved antimicrobial prescribing in the paediatric EDOU. These findings support the need for continued efforts in ASP, emphasising the development and implementation of guidelines, RDTs, and staff stabi…
View article: Nosocomial Transmission of <i>Plasmodium falciparum</i> Malaria, Spain, 2024
Nosocomial Transmission of <i>Plasmodium falciparum</i> Malaria, Spain, 2024 Open
We report nosocomial Plasmodium falciparum malaria in Spain, which was confirmed microbiologically and genomically. Transmission occurred through insufficiently disinfected reusable syringe lead shielding during thyroid scintigraphy. Genom…
View article: A Selective Chromogenic Medium for Detecting Meropenem-Resistant Pseudomonas aeruginosa in Respiratory Samples
A Selective Chromogenic Medium for Detecting Meropenem-Resistant Pseudomonas aeruginosa in Respiratory Samples Open
Background/Objectives: Meropenem is widely used to treat Pseudomonas aeruginosa infections; however, the pathogen’s increasing resistance compromises its efficacy. In this study, we aimed to develop a selective culture medium for detecting…
View article: SARS-CoV-2 post-acute sequelae linked to inflammation via extracellular vesicles
SARS-CoV-2 post-acute sequelae linked to inflammation via extracellular vesicles Open
Background Despite the efficacy of SARS-CoV-2 vaccines in reducing mortality and severe cases of COVID-19, a proportion of survivors experience long-term symptoms, known as post-acute sequelae of SARS-CoV-2 infection (PASC). This study inv…
View article: Selective Chromogenic Medium for Detection of Meropenem-Resistant Pseudomonas aeruginosa in Respiratory Samples
Selective Chromogenic Medium for Detection of Meropenem-Resistant Pseudomonas aeruginosa in Respiratory Samples Open
Background/Objectives: Meropenem (MER) is widely used for the treatment of Pseudomonas aeruginosa infections; however, increasing resistance compromises its efficacy. This study aimed to develop a selective culture medium for the detection…
View article: Could the Adoptive Transfer of Memory Lymphocytes be an Alternative Treatment for Acinetobacter baumannii Infections?
Could the Adoptive Transfer of Memory Lymphocytes be an Alternative Treatment for Acinetobacter baumannii Infections? Open
We evaluated the efficacy of the adoptive transfer of memory B, CD4+, and CD8+ T lymphocytes compared with sulbactam and tigecycline in an experimental murine pneumonia model by two multidrug-resistant Acinetobacter baumannii strains, coli…
View article: Mitomycin C as an Anti-Persister Strategy against Klebsiella pneumoniae: Toxicity and Synergy Studies
Mitomycin C as an Anti-Persister Strategy against Klebsiella pneumoniae: Toxicity and Synergy Studies Open
The combination of several therapeutic strategies is often seen as a good way to decrease resistance rates, since bacteria can more easily overcome single-drug treatments than multi-drug ones. This strategy is especially attractive when se…
View article: A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19
A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19 Open
Background Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with coronavirus disease 2019 (COVID-19). NEP…
View article: Mitomycin C as an Anti-persister Strategy Against Klebsiella Pneumoniae: Toxicity and Synergy Studies
Mitomycin C as an Anti-persister Strategy Against Klebsiella Pneumoniae: Toxicity and Synergy Studies Open
The combination of several therapeutic strategies is often seen as a good way to decrease the resistance rates, since bacteria overcome better single-drug treatments than multi-drug ones. This strategy is especially attractive when several…
View article: Antimicrobial Stewardship in the Emergency Department Observation Unit: Definition of a New Indicator and Evaluation of Antimicrobial Use and Clinical Outcomes
Antimicrobial Stewardship in the Emergency Department Observation Unit: Definition of a New Indicator and Evaluation of Antimicrobial Use and Clinical Outcomes Open
We aimed to define a novel indicator for monitoring antimicrobial use specifically in the Emergency Department Observation Unit (EDOU) and to assess the long-term impact of an institutional education-based antimicrobial stewardship program…
View article: C-terminal deletion of RelA protein is suggested as a possible cause of infective endocarditis recurrence with <i>Enterococcus faecium</i>
C-terminal deletion of RelA protein is suggested as a possible cause of infective endocarditis recurrence with <i>Enterococcus faecium</i> Open
Infective endocarditis (IE) caused by Enterococcus spp. represents the third most common cause of IE, with high rates of relapse compared with other bacteria. Interestingly, late relapses (>6 months) have only been described in Enterococcu…
View article: Current practice of screening and antimicrobial prophylaxis to prevent Gram-negative bacterial infection in high-risk haematology patients: results from a pan-European survey
Current practice of screening and antimicrobial prophylaxis to prevent Gram-negative bacterial infection in high-risk haematology patients: results from a pan-European survey Open
Background: Bacterial infections frequently occur in haematological patients, especially during prolonged neutropenia after intensive chemotherapy, often leading to bloodstream infections and pneumonia. Objective: Routine antimicrobial pro…