Miguel Gomez Fontela
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View article: A novel CD28-mutant CAR with improved IL-2 secretion and enhanced antitumor efficacy in a model of pancreatic cancer 3805
A novel CD28-mutant CAR with improved IL-2 secretion and enhanced antitumor efficacy in a model of pancreatic cancer 3805 Open
Description CD28-derived co-stimulation modules are frequently included in the signaling domain of chimeric antigen receptors (CAR). These modules contain well characterized tyrosine-containing moieties (YMNM and PYAP) that become phosphor…
View article: Supplemental Figure 1. from Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN)
Supplemental Figure 1. from Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN) Open
Supplemental Figure 1. Average proportion of tumor-specific mutations classified as putative class I neoantigens, according to HIV status and cancer site. Statistical comparisons (p-values) were computed using a Wilcoxon test.
View article: Data from Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN)
Data from Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN) Open
Background:People living with HIV (PWH) have improved life expectancy because of effective human immunodeficiency virus (HIV) therapy but still experience immune impairment (e.g., altered CD4/CD8 T cells). We hypothesized that tumors diagn…
View article: Supplemental Table 1 from Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN)
Supplemental Table 1 from Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN) Open
Supplemental Table 1: Average genomic features by cancer patient HIV status, listed by cancer site
View article: Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN)
Elevated Tumor Mutation Burden in Cancer Patients with Underlying HIV Infection: Data from the Oncology Research Information Exchange Network (ORIEN) Open
Background: People living with HIV (PWH) have improved life expectancy because of effective human immunodeficiency virus (HIV) therapy but still experience immune impairment (e.g., altered CD4/CD8 T cells). We hypothesized that tumors diag…
View article: 1375 A hormone-based bispecific T cell engager (BiTE)-like molecule for the treatment of neuroendocrine tumors
1375 A hormone-based bispecific T cell engager (BiTE)-like molecule for the treatment of neuroendocrine tumors Open
Background We designed a novel bispecific T-cell engager (BiTE) targeting the somatostatin receptor (SSTR), which is overexpressed by well-differentiated neuroendocrine tumors (NETs). In our BiTE, the single chain variable fragment (scFV) …
View article: 225 Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) immune checkpoint as a modulator of T-cell effector function
225 Killer cell immunoglobulin-like receptor 2DL2 (KIR2DL2) immune checkpoint as a modulator of T-cell effector function Open
Background Killer immunoglobulin-like receptors (KIRs) are a family of regulatory cell surface molecules expressed on natural killer (NK) cells and in subsets of memory T cells.1,2 Interaction of KIR2DL2 with its HLA-C1 ligands leads to in…
View article: Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2)
Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) Open
The HLA-B*27:05 allele and the endoplasmic reticulum-resident aminopeptidases are strongly associated with AS, a chronic inflammatory spondyloarthropathy. This study examined the effect of ERAP2 in the generation of the natural HLA-B*27:05…
View article: Fluorescence enhanced BA-LIFT for single cell detection and isolation
Fluorescence enhanced BA-LIFT for single cell detection and isolation Open
Laser bioprinting is a term that refers to a group of laser-based techniques for printing living cells with high precision and good viability. Most of these techniques are based on modifications of the standard laser induced forward transf…
View article: The Conserved Non-Coding Sequence 2 (CNS2) Enhances CD69 Transcription through Cooperation between the Transcription Factors Oct1 and RUNX1
The Conserved Non-Coding Sequence 2 (CNS2) Enhances CD69 Transcription through Cooperation between the Transcription Factors Oct1 and RUNX1 Open
The immune regulatory receptor CD69 is expressed upon activation in all types of leukocytes and is strongly regulated at the transcriptional level. We previously described that, in addition to the CD69 promoter, there are four conserved no…
View article: Assessment of geometry in 2D immune systems using high accuracy laser-based bioprinting techniques (Conference Presentation) (Withdrawal Notice)
Assessment of geometry in 2D immune systems using high accuracy laser-based bioprinting techniques (Conference Presentation) (Withdrawal Notice) Open
Publisher's Note: This conference presentation, originally published on 4/19/17, was withdrawn per author request. The immune system is a very complex system that comprises a network of genetic and signaling pathways subtending a network o…