Miguel Torralba
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View article: [Artículo traducido] Estudio piloto para evaluar la relación entre el tipo, la ubicación y la profundidad de las lesiones osteocondrales del astrágalo y la inestabilidad del tobillo
[Artículo traducido] Estudio piloto para evaluar la relación entre el tipo, la ubicación y la profundidad de las lesiones osteocondrales del astrágalo y la inestabilidad del tobillo Open
View article: Genotyping not required for sustained effectiveness of long-acting cabotegravir plus rilpivirine: evidence from the RELATIVITY cohort
Genotyping not required for sustained effectiveness of long-acting cabotegravir plus rilpivirine: evidence from the RELATIVITY cohort Open
Objectives: Long-acting injectable cabotegravir and rilpivirine (LAI CAB+RPV) provides an alternative to daily therapy for people with HIV (PWH) with virologic suppression. Although genotypic testing is recommended before switching, its re…
View article: Clinical outcomes of long‐acting cabotegravir and rilpivirine in people with <scp>HIV</scp> aged 60 and older: Real‐world data from the Spanish <scp>RELATIVITY</scp> cohort
Clinical outcomes of long‐acting cabotegravir and rilpivirine in people with <span>HIV</span> aged 60 and older: Real‐world data from the Spanish <span>RELATIVITY</span> cohort Open
Background Long‐acting injectable cabotegravir and rilpivirine (LAI CAB + RPV) is an established maintenance strategy for people with HIV who are virologically suppressed, providing high efficacy and convenience in treatment. However, evid…
View article: Critical Appraisal Tools for Evaluating Artificial Intelligence in Clinical Studies: Scoping Review
Critical Appraisal Tools for Evaluating Artificial Intelligence in Clinical Studies: Scoping Review Open
Background Health research that uses predictive and generative artificial intelligence (AI) is rapidly growing. As in traditional clinical studies, the way in which AI studies are conducted can introduce systematic errors. The translation …
View article: Data avaliability for "Critical appraisal tools for Artificial Intelligence clinical Studies. A scoping review" (Preprint)
Data avaliability for "Critical appraisal tools for Artificial Intelligence clinical Studies. A scoping review" (Preprint) Open
BACKGROUND Health research that uses predictive and/or generative AI is rapidly growing. Just as in traditional clinical studies, the way in which AI studies are conducted can introduce systematic errors. Transmission of this AI evidence …
View article: Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults with HIV (INSTINCT/GESIDA10918 Study)
Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults with HIV (INSTINCT/GESIDA10918 Study) Open
Background Dual antiretroviral therapy (ART) with dolutegravir/lamivudine (DTG/3TC) is widely used in virologically suppressed individuals. However, data remain limited on potential differential effects of ART regimens on mid-term systemic…
View article: Estudio piloto para evaluar la relación entre el tipo, la ubicación y la profundidad de las lesiones osteocondrales del astrágalo y la inestabilidad del tobillo
Estudio piloto para evaluar la relación entre el tipo, la ubicación y la profundidad de las lesiones osteocondrales del astrágalo y la inestabilidad del tobillo Open
View article: ¿Cuidar enferma? Sobrecarga del cuidador informal de pacientes dependientes y su impacto en la salud (oral)
¿Cuidar enferma? Sobrecarga del cuidador informal de pacientes dependientes y su impacto en la salud (oral) Open
Objetivos Valorar la repercusión en la vida y la salud de cuidadores informales como consecuencia de cuidar a una persona dependiente crónica. En este sentido, se plantea un análisis de la sobrecarga de la persona que cuida, con los siguie…
View article: P-561. Long-Acting Cabotegravir and Rilpivirine in HIV Individuals Over 60 years: a Real-World Study (RELATIVITY Cohort)
P-561. Long-Acting Cabotegravir and Rilpivirine in HIV Individuals Over 60 years: a Real-World Study (RELATIVITY Cohort) Open
Background The switching strategy to long-acting cabotegravir and rilpivirine (CAB+RPV) has emerged as a standard approach for people living with HIV (PLWH), offering high efficacy, safety, and convenience rates. Nevertheless, there is a s…
View article: Use and Effectiveness of Carboximaltose Iron in Preoperative Anemia Treatment: A Multicenter and Retrospective Study
Use and Effectiveness of Carboximaltose Iron in Preoperative Anemia Treatment: A Multicenter and Retrospective Study Open
Low percentage of patients achieved a hemoglobin level of 13 g/dL or experienced an increase in hemoglobin of 1 g/dL or more following the administration of FCM, indicating the low effectiveness of FCM in treating perioperative anaemia in …
View article: A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19
A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19 Open
Background Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with coronavirus disease 2019 (COVID-19). NEP…
View article: Assessment of Albumin-Incorporating Scores at Hepatocellular Carcinoma Diagnosis Using Machine Learning Techniques: An Evaluation of Prognostic Relevance
Assessment of Albumin-Incorporating Scores at Hepatocellular Carcinoma Diagnosis Using Machine Learning Techniques: An Evaluation of Prognostic Relevance Open
Hepatocellular carcinoma (HCC) presents high mortality rates worldwide, with limited evidence on prognostic factors at diagnosis. This study evaluates the utility of common scores incorporating albumin as predictors of mortality at HCC dia…
View article: Early Detection of Cancer and Precancerous Lesions in Persons With HIV Through a Comprehensive Cancer Screening Protocol
Early Detection of Cancer and Precancerous Lesions in Persons With HIV Through a Comprehensive Cancer Screening Protocol Open
Background Non-AIDS defining malignancies present a growing challenge for persons with human immunodeficiency virus (HIV, PWH), yet tailored interventions for timely cancer diagnosis are lacking. The Spanish IMPAC-Neo protocol was designed…
View article: Leprosy in Spain: A Descriptive Study of Admissions at Fontilles Sanatorium between 1909 and 2020
Leprosy in Spain: A Descriptive Study of Admissions at Fontilles Sanatorium between 1909 and 2020 Open
Background: The study aimed to characterize patients with leprosy admitted to Fontilles throughout the 20th and 21st centuries, focusing on differences across three periods (I, II, and III). It also explored variables linked to patient sur…
View article: Prognostic Impact of Metabolic Syndrome and Steatotic Liver Disease in Hepatocellular Carcinoma Using Machine Learning Techniques
Prognostic Impact of Metabolic Syndrome and Steatotic Liver Disease in Hepatocellular Carcinoma Using Machine Learning Techniques Open
Metabolic dysfunction-associated steatotic liver disease (MASLD) currently represents the predominant cause of chronic liver disease and is closely linked to a significant increase in the risk of hepatocellular carcinoma (HCC), even in the…
View article: HBsAg level defines different clinical phenotypes of HBeAg(−) chronic HBV infection related to HBV polymerase-specific CD8+ cell response quality
HBsAg level defines different clinical phenotypes of HBeAg(−) chronic HBV infection related to HBV polymerase-specific CD8+ cell response quality Open
Background HBe-antigen(Ag)-negative chronic hepatitis B virus (HBV) infection is characterized by little liver fibrosis progression and vigorous HBV-multispecific CD8 + T-cell response. Aims To assess whether HBsAg level could discriminate…
View article: Machine Learning-Based Assessment of Survival and Risk Factors in Non-Alcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma for Optimized Patient Management
Machine Learning-Based Assessment of Survival and Risk Factors in Non-Alcoholic Fatty Liver Disease-Related Hepatocellular Carcinoma for Optimized Patient Management Open
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, with an incidence that is exponentially increasing. Hepatocellular carcinoma (HCC) is the most frequent primary tumor. There is an increasing rel…
View article: Prognostic Factors for Mortality in Hepatocellular Carcinoma at Diagnosis: Development of a Predictive Model Using Artificial Intelligence
Prognostic Factors for Mortality in Hepatocellular Carcinoma at Diagnosis: Development of a Predictive Model Using Artificial Intelligence Open
Background: Hepatocellular carcinoma (HCC) accounts for 75% of primary liver tumors. Controlling risk factors associated with its development and implementing screenings in risk populations does not seem sufficient to improve the prognosis…
View article: Application of Machine Learning Techniques to Assess Alpha-Fetoprotein at Diagnosis of Hepatocellular Carcinoma
Application of Machine Learning Techniques to Assess Alpha-Fetoprotein at Diagnosis of Hepatocellular Carcinoma Open
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and is associated with high mortality rates. Approximately 80% of cases occur in cirrhotic livers, posing a significant challenge for appropriate therapeutic management.…
View article: Bull horn injuries, analysis of 138 cases
Bull horn injuries, analysis of 138 cases Open
Objective: Bull-horn injuries (BHI) are unique and there is reduced published literature about it.We present an analysis of a 11-year BHI case series.Method: Retrospective and analytical study of 138 cases developed during a 11-year period…
View article: IL-15 boosts activated HBV core-specific CD8+ progenitor cells via metabolic rebalancing in persistent HBV infection
IL-15 boosts activated HBV core-specific CD8+ progenitor cells via metabolic rebalancing in persistent HBV infection Open
A rebalance between energy supply and demand in HBV-specific-CD8+ activated progenitor (AP) cells could restore the functionality of proliferative progeny (PP) in e-antigen(Ag)-negative chronic hepatitis B (CHBe(-)). We observed…
View article: Effectiveness, durability and safety of dolutegravir and lamivudine versus bictegravir, emtricitabine and tenofovir alafenamide in a real-world cohort of HIV-infected adults
Effectiveness, durability and safety of dolutegravir and lamivudine versus bictegravir, emtricitabine and tenofovir alafenamide in a real-world cohort of HIV-infected adults Open
Objective Dolutegravir plus lamivudine (2-DR) is suggested as an initial and switch option in HIV-1 treatment. The aim of this study was to analyze the effectiveness, durability, and safety of 2-DR compared to bictegravir/emtricitabine/ten…
View article: Correction: Impact of an enhanced screening program on the detection of non-AIDS neoplasias in patients with human immunodeficiency virus infection
Correction: Impact of an enhanced screening program on the detection of non-AIDS neoplasias in patients with human immunodeficiency virus infection Open
View article: Cabotegravir and Rilpivirine Long-Acting Antiretroviral Therapy Administered Every 2 Months is Cost-Effective for the Treatment of HIV-1 in Spain
Cabotegravir and Rilpivirine Long-Acting Antiretroviral Therapy Administered Every 2 Months is Cost-Effective for the Treatment of HIV-1 in Spain Open
ATLAS, NCT02951052; ATLAS-2M, NCT03299049; FLAIR, NCT02938520.
View article: 5PSQ-136 Analysis of antiretroviral therapy potency in HIV- naïve patients
5PSQ-136 Analysis of antiretroviral therapy potency in HIV- naïve patients Open
Background and Importance Clinical practice guidelines recommend initiation of antiretroviral therapy (ART) as soon as possible after diagnosis of HIV infection with a combination of nucleoside reverse transcriptase inhibitors (NRTI) with …
View article: Plitidepsin in adult patients with COVID-19 requiring hospital admission: A long-term follow-up analysis
Plitidepsin in adult patients with COVID-19 requiring hospital admission: A long-term follow-up analysis Open
Introduction The APLICOV-PC study assessed the safety and preliminary efficacy of plitidepsin in hospitalized adult patients with COVID-19. In this follow-up study (E-APLICOV), the incidence of post-COVID-19 morbidity was evaluated and any…
View article: Effects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV
Effects of frailty, geriatric syndromes, and comorbidity on mortality and quality of life in older adults with HIV Open
View article: 48-Week effectiveness and tolerability of dolutegravir (DTG) + lamivudine (3TC) in antiretroviral-naïve adults living with HIV: A multicenter real-life cohort
48-Week effectiveness and tolerability of dolutegravir (DTG) + lamivudine (3TC) in antiretroviral-naïve adults living with HIV: A multicenter real-life cohort Open
Background The main international guidelines indicate DTG/3TC therapy as one of the preferred regimens for people living with HIV (PLWH), due to its observed efficacy in randomized clinical trials. However, information in real-life cohorts…
View article: Letter: the probability to predict <scp>HBV</scp>‐specific <scp>CD8</scp>+ cell response derived from <scp>HLA‐A2</scp>+ may not foresee the functional cure well in Asian off‐therapy cohort—authors' reply
Letter: the probability to predict <span>HBV</span>‐specific <span>CD8</span>+ cell response derived from <span>HLA‐A2</span>+ may not foresee the functional cure well in Asian off‐therapy cohort—authors' reply Open
LINKED CONTENT This article is linked to Pena‐Asensio et al papers. To view these articles, visit https://doi.org/10.1111/apt.16850 and https://doi.org/10.1111/apt.17199
View article: Tenofovir Disoproxil Fumarate/Emtricitabine and Baricitinib for Patients at High Risk of Severe Coronavirus Disease 2019: The PANCOVID Randomized Clinical Trial
Tenofovir Disoproxil Fumarate/Emtricitabine and Baricitinib for Patients at High Risk of Severe Coronavirus Disease 2019: The PANCOVID Randomized Clinical Trial Open
Background This study was designed to evaluate if patients with high risk for severe coronavirus disease 2019 (COVID-19) would benefit from treatment with tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) followed by baricitinib in cas…