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Proinsulin C-peptide is a major source of HLA-DQ8 restricted hybrid insulin peptides recognized by human islet-infiltrating CD4+ T cells Open

Pushpak Bhattacharjee, Miha Pakusch, Matthew Lacorcia, Eleonora Tresoldi, Alan F. Rubin , et al. · 2024

Type 1 diabetes (T1D) is an autoimmune disease that develops when T cells destroy the insulin-producing beta cells that reside in the pancreatic islets. Immune cells, including T cells, infiltrate the islets and gradually destroy the beta …

A minority of proliferating human CD4+ T cells in antigen-driven proliferation assays are antigen specific Open

Pushpak Bhattacharjee, Miha Pakusch, Matthew Lacorcia, Chris Chiu, Xin Liu , et al. · 2024

Antigen-driven T-cell proliferation is often measured using fluorescent dye dilution assays, such as the CFSE-based proliferation assay. Dye dilution assays have been powerful tools to detect human CD4 + T-cell responses, particularly agai…

Proinsulin C-peptide is a major source of HLA-DQ8 restricted HIPs recognized by human Islet-Infiltrating CD4<sup>+</sup>T cells Open

Pushpak Bhattacharjee, Miha Pakusch, Matthew Lacorcia, Eleonora Tresoldi, Alan F. Rubin , et al. · 2024

Type 1 diabetes (T1D) is an autoimmune disease that develops when T cells destroy the pancreatic insulin-producing beta cells that reside in the pancreatic islets. Immune cells, including T cells infiltrate the islets and gradually destroy…

Supplementary Tables S3-S4 from Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor Open

Huei San Leong, Kelan Chen, Yifang Hu, Stanley Chun-Wei Lee, Jason Corbin , et al. · 2023

Supplementary Tables S3-S4 XLSX file - 576K, Gene set analysis (Camera) and differentially expressed genes

Supplementary Tables S3-S4 from Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor Open

Huei San Leong, Kelan Chen, Yifang Hu, Stanley Chun-Wei Lee, Jason Corbin , et al. · 2023

Supplementary Tables S3-S4 XLSX file - 576K, Gene set analysis (Camera) and differentially expressed genes

Supplementary Material from Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor Open

Huei San Leong, Kelan Chen, Yifang Hu, Stanley Chun-Wei Lee, Jason Corbin , et al. · 2023

Supplementary Material PDF file - 709K, Supplementary Tables 1 and 2, supplementary methods, supplementary figure legends and supplementary figures

Supplementary Material from Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor Open

Huei San Leong, Kelan Chen, Yifang Hu, Stanley Chun-Wei Lee, Jason Corbin , et al. · 2023

Supplementary Material PDF file - 709K, Supplementary Tables 1 and 2, supplementary methods, supplementary figure legends and supplementary figures

Data from Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor Open

Huei San Leong, Kelan Chen, Yifang Hu, Stanley Chun-Wei Lee, Jason Corbin , et al. · 2023

SMCHD1 is an epigenetic modifier of gene expression that is critical to maintain X chromosome inactivation. Here, we show in mouse that genetic inactivation of Smchd1 accelerates tumorigenesis in male mice. Loss of Smchd1 in transfo…

Data from Epigenetic Regulator Smchd1 Functions as a Tumor Suppressor Open

Huei San Leong, Kelan Chen, Yifang Hu, Stanley Chun-Wei Lee, Jason Corbin , et al. · 2023

SMCHD1 is an epigenetic modifier of gene expression that is critical to maintain X chromosome inactivation. Here, we show in mouse that genetic inactivation of Smchd1 accelerates tumorigenesis in male mice. Loss of Smchd1 in transfo…

Glutamine deamidation does not increase the immunogenicity of C-peptide in people with type 1 diabetes Open

Abby Foster, Pushpak Bhattacharjee, Eleonora Tresoldi, Miha Pakusch, Fergus Cameron , et al. · 2022

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation Open

Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen , et al. · 2022

Xmas ESC: A new female embryonic stem cell system that reveals the BAF complex as a key regulator of the establishment of X chromosome inactivation Open

Andrew Keniry, Natasha Jansz, Linden J. Gearing, Iromi Wanigasuriya, Joseph Chen , et al. · 2019

Summary Although female pluripotency significantly differs to male, complications with in vitro culture of female embryonic stem cells (ESC) have severely limited the use and study of these cells. We report a replenishable female ESC syste…

Proinsulin C-peptide is an autoantigen in people with type 1 diabetes Open

Michelle So, Colleen M. Elso, Eleonora Tresoldi, Miha Pakusch, Vimukthi Pathiraja , et al. · 2018

Significance Type 1 diabetes (T1D) is an incurable autoimmune disease caused by T cell-mediated destruction of insulin-producing beta cells. The beta-cell antigens recognized by human CD4 + T cells in T1D are poorly defined. Here, we show …

Smchd1 haploinsufficiency exacerbates the phenotype of a transgenic FSHD1 mouse model Open

Jessica C. de Greef, Yvonne D. Krom, Bianca den Hamer, Lauren Snider, Yosuke Hiramuki , et al. · 2017

In humans, a copy of the DUX4 retrogene is located in each unit of the D4Z4 macrosatellite repeat that normally comprises 8-100 units. The D4Z4 repeat has heterochromatic features and does not express DUX4 in somatic cells. Individuals wit…

Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing Open

Andrew Keniry, Linden J. Gearing, Natasha Jansz, Joy Liu, Aliaksei Z. Holik , et al. · 2016

Here we have shown that H3K9 methylation clearly marks the murine inactive X chromosome. The role of this mark is most apparent during the establishment phase of gene silencing, with a more muted effect on maintenance of the silent state. …

MOESM5 of Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing Open

Andrew Keniry, Linden J. Gearing, Natasha Jansz, Joy Liu, Aliaksei Z. Holik , et al. · 2016

Additional file 5. H3K9 methyltransferase knockdown validation. qRT-PCR of H3K9 methyltransferase expression levels in cells transduced with H3K9 methyltransferase shRNAs, 3 days after transduction. Results are relative to the average of h…

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