Clara M. Ionescu
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View article: Revisiting the impulse response creates an improved PID autotuner
Revisiting the impulse response creates an improved PID autotuner Open
Industrial practice navigates a robust controller tuning due to fairly uncertain process information. A comprehensive process identification is often avoided due to operating conditions, continuous manufacturing, etc. When process properti…
View article: Modeling drug retention as memory effects in obese patients using fractional and augmented models
Modeling drug retention as memory effects in obese patients using fractional and augmented models Open
View article: In-silico evaluation of three control methodologies with model adaptation to minimize risk of overdosing in anesthesia
In-silico evaluation of three control methodologies with model adaptation to minimize risk of overdosing in anesthesia Open
View article: Pharmacokinetic modelling during long-term anesthesia: minimizing the gap
Pharmacokinetic modelling during long-term anesthesia: minimizing the gap Open
The augmented model with MPC minimizes drug trapping and reduces total drug use, lowering overdose risk and supporting safer anesthesia management.
View article: Online and personalised control of the Depth of hypnosis during induction using fractional order PID
Online and personalised control of the Depth of hypnosis during induction using fractional order PID Open
The online adaptation that this research brings, compared to the previous attempts, allows for significantly improved results for the hypnosis phase.
View article: Integrated Solution Combining Low-Frequency Forced Oscillation Technique and Continuous Equivital Sensor Monitoring for Assessment of Non-Invasive Ambulatory Respiratory Mechanics
Integrated Solution Combining Low-Frequency Forced Oscillation Technique and Continuous Equivital Sensor Monitoring for Assessment of Non-Invasive Ambulatory Respiratory Mechanics Open
Early assessment of respiratory mechanics is crucial for early-stage diagnosing and managing lung diseases, leading to greater patient outcomes. Traditional methods like spirometry are limited in continuous monitoring and patient complianc…
View article: Toward Personalized Surgery in Advanced Prostate Cancer: Stratification by PTEN, AR-V7, TP53, TMPRSS2-ERG, and ERBB2 Genetic Alterations
Toward Personalized Surgery in Advanced Prostate Cancer: Stratification by PTEN, AR-V7, TP53, TMPRSS2-ERG, and ERBB2 Genetic Alterations Open
Background: Advanced prostate cancer is a biologically heterogeneous disease often marked by multiple genetic and epigenetic alterations that influence tumor progression, treatment resistance, and prognosis. Among the most frequentl…
View article: Modeling, analysis and experimental observations of fat volume properties in compartmental models for drug pharmacokinetics
Modeling, analysis and experimental observations of fat volume properties in compartmental models for drug pharmacokinetics Open
Drug related dynamic uptake, clearance and anomalous diffusion patterns are dependent of biological tissue composition. Of particular importance is the fat volume, where drug trapping occurs in long term usage and related to lipophilic pro…
View article: Histopathological Profile of Prostatic Lesions and the Role of Gleason Score in Surgical Treatment Decision-Making
Histopathological Profile of Prostatic Lesions and the Role of Gleason Score in Surgical Treatment Decision-Making Open
Introduction: The Gleason score plays a key role in risk stratification and surgical treatment selection for prostate cancer. This study evaluates the correlation between Gleason score, patient age, and tumor aggressiveness, with im…
View article: A Novel Approach to Robust PID Autotuner for Overdamped Systems: Case Study on Liquid Level System
A Novel Approach to Robust PID Autotuner for Overdamped Systems: Case Study on Liquid Level System Open
This paper proposes and validates an automatic control tuning methodology based on initial frequency response. This approach facilitates the design of robust PID controllers for overdamped systems characterized by S-shaped step responses. …
View article: A Novel Decentralized–Decoupled Fractional-Order Control Strategy for Complete Anesthesia–Hemodynamic Stabilization in Patients Undergoing Surgical Procedures
A Novel Decentralized–Decoupled Fractional-Order Control Strategy for Complete Anesthesia–Hemodynamic Stabilization in Patients Undergoing Surgical Procedures Open
Within biomedical engineering, there has been significant collaboration among clinicians, control engineers, and researchers to tailor treatments to individual patients. Anesthesia is integral to numerous medical procedures, necessitating …
View article: Fractional-Order Modeling of the Depth of Analgesia as Reference Model for Control Purposes
Fractional-Order Modeling of the Depth of Analgesia as Reference Model for Control Purposes Open
Little research has been carried out in terms of modeling and control of analgesia. However, emerging new technology and recent prototypes paved the way for several ideas on pain modeling for control. Recently, such an idea has been propos…
View article: Artificial Intelligence-Driven Prognosis of Respiratory Mechanics: Forecasting Tissue Hysteresivity Using Long Short-Term Memory and Continuous Sensor Data
Artificial Intelligence-Driven Prognosis of Respiratory Mechanics: Forecasting Tissue Hysteresivity Using Long Short-Term Memory and Continuous Sensor Data Open
Tissue hysteresivity is an important marker for determining the onset and progression of respiratory diseases, calculated from forced oscillation lung function test data. This study aims to reduce the number and duration of required measur…
View article: Sustainability and predictive accuracy evaluation of gel and embroidered electrodes for ECG monitoring
Sustainability and predictive accuracy evaluation of gel and embroidered electrodes for ECG monitoring Open
View article: Selecting Optimal Long Short-Term Memory (LSTM) Architectures for Online Estimation of Mean Arterial Pressure (MAP) in Patients Undergoing General Anesthesia
Selecting Optimal Long Short-Term Memory (LSTM) Architectures for Online Estimation of Mean Arterial Pressure (MAP) in Patients Undergoing General Anesthesia Open
In the realm of anesthetic management during surgical procedures, the reliable estimation of mean arterial pressure (MAP) is critical for ensuring patient safety and optimizing drug administration. This paper investigates the determination…
View article: Comparative Analysis of Pharmacokinetic-Pharmacodynamic Models for Propofol and Remifentanil Using Model Predictive Control
Comparative Analysis of Pharmacokinetic-Pharmacodynamic Models for Propofol and Remifentanil Using Model Predictive Control Open
This study aims to compare the effectiveness of different Pharmacokinetic-Pharmacodynamic (PK-PD) models for administering Propofol and Remifentanil, two critical agents in anesthesia. Initially, different PK models were introduced: one fo…
View article: Enhancing Pain Level Assessment in Post-Surgery Patients Using Artificial Intelligence Algorithms
Enhancing Pain Level Assessment in Post-Surgery Patients Using Artificial Intelligence Algorithms Open
Control performance decreases significantly in the presence of uncertainty in variable availability, measurement noise, or instrumentation failure. In cluttered environments such as the Post Anesthesia Care Unit (PACU), clinical measures a…
View article: Data-driven identification and comparison of full multivariable models for propofol–remifentanil induced general anesthesia
Data-driven identification and comparison of full multivariable models for propofol–remifentanil induced general anesthesia Open
View article: Development, Validation, and Comparison of a Novel Nociception/Anti-Nociception Monitor against Two Commercial Monitors in General Anesthesia
Development, Validation, and Comparison of a Novel Nociception/Anti-Nociception Monitor against Two Commercial Monitors in General Anesthesia Open
In this paper, we present the development and the validation of a novel index of nociception/anti-nociception (N/AN) based on skin impedance measurement in time and frequency domain with our prototype AnspecPro device. The primary objectiv…
View article: Fractional order MRAC control design for a lightning system based on a fractional order second degree model
Fractional order MRAC control design for a lightning system based on a fractional order second degree model Open
View article: First-Hand Design of a Fractional order PID for Controlling the Depth of Hypnosis during Induction
First-Hand Design of a Fractional order PID for Controlling the Depth of Hypnosis during Induction Open
The integration of information technology and control engineering has significantly increased in the research field of clinical practice, including the management of medication dosing for general anesthesia. To achieve effective drug dosin…
View article: Sustainability and Predictive Accuracy Evaluation of Gel and Embroidered Electrodes for ECG Monitoring
Sustainability and Predictive Accuracy Evaluation of Gel and Embroidered Electrodes for ECG Monitoring Open
View article: Model Extraction From Clinical Data Subject to Large Uncertainties and Poor Identifiability
Model Extraction From Clinical Data Subject to Large Uncertainties and Poor Identifiability Open
This letter presents an extension to system theory as a novel approach to provide models from clinical data under large uncertainty and poor identifiability conditions. These difficult conditions are often present in medical systems due to…
View article: An adaptive control structure to mitigate lack of feasibility in systems with poor identifiability. Case Study on General Anesthesia
An adaptive control structure to mitigate lack of feasibility in systems with poor identifiability. Case Study on General Anesthesia Open
View article: A practical approach for transfer function estimation using short, transient process data
A practical approach for transfer function estimation using short, transient process data Open
View article: PID control of data-driven patient response with fixed ratio co-administration of drugs for depth of hypnosis
PID control of data-driven patient response with fixed ratio co-administration of drugs for depth of hypnosis Open
View article: A fractional order impedance model for heterogeneous drug distribution in obese patients during general anesthesia
A fractional order impedance model for heterogeneous drug distribution in obese patients during general anesthesia Open
Personalised pharmacokinetic models imply stepping away from the classical assumption of homogeneous drug mixing in various tissue compartments in the body, with a particular impact on obese patients. In this work, the pharmacokinetic comp…
View article: Fractional Order PID Control of Propofol Dosage and Optimization in Lean and Obese Patients
Fractional Order PID Control of Propofol Dosage and Optimization in Lean and Obese Patients Open
This paper outlines the design of a fractional-order proportional integral derivative controller for regulating the induction phase of Propofol infusion in lean and obese patients. The obtained controller is implemented within the pharmaco…
View article: Validation of Delayed Anesthesia Model Using Identification Methods and Correlation Analysis
Validation of Delayed Anesthesia Model Using Identification Methods and Correlation Analysis Open
View article: A performant PID autotuner based on a short relay test
A performant PID autotuner based on a short relay test Open