Mihaela Lorger
YOU?
Author Swipe
View article: Natural killer cells are required for the recruitment of CD8+ T cells and the efficacy of immune checkpoint blockade in melanoma brain metastases
Natural killer cells are required for the recruitment of CD8+ T cells and the efficacy of immune checkpoint blockade in melanoma brain metastases Open
Background Brain metastases (BrM) affect up to 60% of patients with metastatic melanoma and are associated with poor prognosis. While combined immune checkpoint blockade of programmed death-1 (PD-1) and cytotoxic T-lymphocyte-associated pr…
View article: Brain endothelial cells promote breast cancer cell extravasation to the brain via EGFR-DOCK4-RAC1 signalling
Brain endothelial cells promote breast cancer cell extravasation to the brain via EGFR-DOCK4-RAC1 signalling Open
The role of endothelial cells in promoting cancer cell extravasation to the brain during the interaction of cancer cells with the vasculature is not well characterised. We show that brain endothelial cells activate EGFR signalling in tripl…
View article: Biglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain
Biglycan and reduced glycolysis are associated with breast cancer cell dormancy in the brain Open
Exit of quiescent disseminated cancer cells from dormancy is thought to be responsible for metastatic relapse and a better understanding of dormancy could pave the way for novel therapeutic approaches. We used an in vivo model of triple ne…
View article: Supplementary Table 1 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
Supplementary Table 1 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines Open
Table containing all brain metastatic cell lines in the BrMPanel
View article: Data from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
Data from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines Open
Spread of cancer to the brain remains an unmet clinical need in spite of the increasing number of cases among patients with lung, breast cancer, and melanoma most notably. Although research on brain metastasis was considered a minor aspect…
View article: Data from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
Data from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines Open
Spread of cancer to the brain remains an unmet clinical need in spite of the increasing number of cases among patients with lung, breast cancer, and melanoma most notably. Although research on brain metastasis was considered a minor aspect…
View article: Supplementary Table 1 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
Supplementary Table 1 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines Open
Table containing all brain metastatic cell lines in the BrMPanel
View article: Figure S1 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
Figure S1 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines Open
This figures describes the use of the BrMPanel for brain metastasis research
View article: Supplementary Table 2 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
Supplementary Table 2 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines Open
Contains experimental therapies tested on brain metastatic cell lines and associated clinical trials
View article: Supplementary Table 2 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
Supplementary Table 2 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines Open
Contains experimental therapies tested on brain metastatic cell lines and associated clinical trials
View article: Figure S1 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
Figure S1 from Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines Open
This figures describes the use of the BrMPanel for brain metastasis research
View article: Do animal models of brain tumors replicate human peritumoral edema? a systematic literature search
Do animal models of brain tumors replicate human peritumoral edema? a systematic literature search Open
Introduction Brain tumors cause morbidity and mortality in part through peritumoral brain edema. The current main treatment for peritumoral brain edema are corticosteroids. Due to the increased recognition of their side-effect profile, the…
View article: Immunotherapy in the context of immune-specialized environment of brain metastases
Immunotherapy in the context of immune-specialized environment of brain metastases Open
Brain metastases (BrM) develop in 20–40% of patients with advanced cancer. They mainly originate from lung cancer, melanoma, breast cancer, and renal cell carcinoma, and are associated with a poor prognosis. While patients with BrM traditi…
View article: P08.02 Harnessing T cells to target brain metastasis
P08.02 Harnessing T cells to target brain metastasis Open
BACKGROUND Up to 60% of melanoma patients develop brain metastases (BrM). These patients have a poor prognosis and limited treatment options. Immune checkpoint inhibitors (ICI) targeting Cytotoxic T-lymphocyte-associated protein-4 (CTLA-4)…
View article: KS01.4.A NK cells as key orchestrators in mediating the anti-tumour response to immune checkpoint blockade in melanoma brain metastases
KS01.4.A NK cells as key orchestrators in mediating the anti-tumour response to immune checkpoint blockade in melanoma brain metastases Open
BACKGROUND Brain metastases (BrM) are an unmet clinical need with poor prognosis. 60% of melanoma patients develop BrM. BrM are strongly understudied due to frequent exclusion from clinical trials, and hence treatment options commonly lag …
View article: Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth
Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth Open
Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive type of liver cancer in urgent need of treatment options. Aberrant activation of the c‐Jun N‐terminal kinase (JNK) pathway is a key feature in ICC and an attr…
View article: Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation
Coordination of asparagine uptake and asparagine synthetase expression modulates CD8+ T cell activation Open
T cell receptor (TCR) triggering by antigen results in metabolic reprogramming that, in turn, facilitates the exit of T cells from quiescence. The increased nutrient requirements of activated lymphocytes are met, in part, by upregulation o…
View article: Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model
Hematopoietic stem cell gene therapy targeting TGFβ enhances the efficacy of irradiation therapy in a preclinical glioblastoma model Open
Patients with glioblastoma (GBM) have a poor prognosis, and inefficient delivery of drugs to tumors represents a major therapeutic hurdle. Hematopoietic stem cell (HSC)-derived myeloid cells efficiently home to GBM and constitute up to 50%…
View article: 52. BrMPANEL: A PUBLIC RESOURCE OF ORGANOTROPIC CELL LINES
52. BrMPANEL: A PUBLIC RESOURCE OF ORGANOTROPIC CELL LINES Open
Central nervous system (CNS), notably brain, metastases are most prevalent in lung cancer (20–56% of patients), breast cancer (5–20%) and melanoma (7–16%). Lesions occur in both the brain parenchyma and the meninges. To mechanistically und…
View article: Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines
Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines Open
Spread of cancer to the brain remains an unmet clinical need in spite of the increasing number of cases among patients with lung, breast cancer, and melanoma most notably. Although research on brain metastasis was considered a minor aspect…
View article: Immune Checkpoint Blockade – How Does It Work in Brain Metastases?
Immune Checkpoint Blockade – How Does It Work in Brain Metastases? Open
Immune checkpoints restrain the immune system following its activation and their inhibition unleashes anti-tumor immune responses. Immune checkpoint inhibitors revolutionized the treatment of several cancer types, including melanoma, and i…
View article: Hematopoietic Stem Cell Gene Therapy for Brain Metastases Using Myeloid Cell–Specific Gene Promoters
Hematopoietic Stem Cell Gene Therapy for Brain Metastases Using Myeloid Cell–Specific Gene Promoters Open
Background Brain metastases (BrM) develop in 20–40% of cancer patients and represent an unmet clinical need. Limited access of drugs into the brain because of the blood-brain barrier is at least partially responsible for therapeutic failur…
View article: KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice
KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice Open
Modulation of energy metabolism with the small-molecule KHS101 promoted tumor-selective death of human glioblastoma cells and reduced tumor growth in mice.
View article: Anti–PD-1/anti–CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8<sup>+</sup>T cell trafficking
Anti–PD-1/anti–CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8<sup>+</sup>T cell trafficking Open
Inhibition of immune checkpoints programmed death 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4) on T cells results in durable antitumor activity in melanoma patients. Despite high frequency of melanoma brain metastases …
View article: The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1
The small molecule KHS101 induces bioenergetic dysfunction in glioblastoma cells through inhibition of mitochondrial HSPD1 Open
Pharmacological inhibition of uncontrolled cell growth with small molecule inhibitors is a potential strategy against glioblastoma multiforme (GBM), the most malignant primary brain cancer. Phenotypic profiling of the neurogenic small mole…
View article: TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p
TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p Open
View article: Metastatic site-specific polarization of macrophages in intracranial breast cancer metastases
Metastatic site-specific polarization of macrophages in intracranial breast cancer metastases Open
In contrast to primary tumors, the understanding of macrophages within metastases is very limited. In order to compare macrophage phenotypes between different metastatic sites, we established a pre-clinical mouse model of intracranial brea…
View article: Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream
Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream Open
View article: CBIO-33INVESTIGATING GLIOMA CELL PHENOTYPES WITH SMALL MOLECULES
CBIO-33INVESTIGATING GLIOMA CELL PHENOTYPES WITH SMALL MOLECULES Open
High-grade brain tumours are characterized by inter- and intratumour heterogeneity and remain incurable despite current multi-modality treatment. The cellular aggressiveness within brain tumours includes tumour cell invasion of healthy bra…
View article: Tumor microenvironment in breast cancer brain metastases
Tumor microenvironment in breast cancer brain metastases Open
B metastases occur in ~15 % of patients with advanced breast cancer. Their incidence is particularly high in triple negative and HER2-positive disease (30-50%). Therapeutic options for brain metastases are limited and patients with central…