Mihaela Stavarache
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View article: Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery
Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery Open
View article: 6-OHDA lesion in medial forebrain bundle v1
6-OHDA lesion in medial forebrain bundle v1 Open
Lesion of the medial forebrain bundle using 6-OHDA to induce parkinsonian-like deficits in mice.
View article: AAV Craniotomy v1
AAV Craniotomy v1 Open
This protocol is for injection of AAV into a mouse brain using a stereotactic frame and Hamilton syringe.
View article: Apomorphine-induced rotations v1
Apomorphine-induced rotations v1 Open
To test for 6-OHDA lesion efficiency, rotational behaviors are assessed while mice are under the effects of apomorphine. This test is run during the dark phase of light cycle. Experiments are performed by an examiner blinded to treatment g…
View article: Feasibility of measuring blood‐brain barrier permeability using ultra‐short echo time radial magnetic resonance imaging
Feasibility of measuring blood‐brain barrier permeability using ultra‐short echo time radial magnetic resonance imaging Open
Background and Purpose The purpose of this study is to evaluate the feasibility of using 3‐dimensional (3D) ultra‐short echo time (UTE) radial imaging method for measurement of the permeability of the blood‐brain barrier (BBB) to gadoliniu…
View article: NEURON-ASTROCYTE INTERACTIONS UNDERLYING NORADRENERGIC MODULATION OF WAKE-PROMOTING VENTRAL PERIAQUEDUCTAL GRAY DOPAMINE NEURONS
NEURON-ASTROCYTE INTERACTIONS UNDERLYING NORADRENERGIC MODULATION OF WAKE-PROMOTING VENTRAL PERIAQUEDUCTAL GRAY DOPAMINE NEURONS Open
View article: SURG-04. INFLUENCE OF LOW-INTENSITY FOCUSED ULTRASOUND ON LOCOREGIONAL DRUG DELIVERY TO THE BRAIN
SURG-04. INFLUENCE OF LOW-INTENSITY FOCUSED ULTRASOUND ON LOCOREGIONAL DRUG DELIVERY TO THE BRAIN Open
INTRODUCTION Efficient delivery of therapeutic drugs across the blood-brain barrier (BBB) for the treatment of central nervous system (CNS) tumors is a major challenge to the development of safe and efficacious therapies. Among the differe…
View article: Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells’ response to Pten deletion
Monocyte-derived SDF1 supports optic nerve regeneration and alters retinal ganglion cells’ response to Pten deletion Open
Significance The optic nerve conveys information from retinal ganglion cells (RGCs) to visual processing areas of the brain. Although this pathway normally cannot regenerate when injured nor in degenerative diseases such as glaucoma, this …
View article: Author Correction: Disruption of mitochondrial complex I induces progressive parkinsonism
Author Correction: Disruption of mitochondrial complex I induces progressive parkinsonism Open
View article: Disruption of mitochondrial complex I induces progressive parkinsonism
Disruption of mitochondrial complex I induces progressive parkinsonism Open
View article: Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression
Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression Open
View article: Estrogen receptors α and β in the central amygdala and the ventromedial nucleus of the hypothalamus: Sociosexual behaviors, fear and arousal in female rats during emotionally challenging events
Estrogen receptors α and β in the central amygdala and the ventromedial nucleus of the hypothalamus: Sociosexual behaviors, fear and arousal in female rats during emotionally challenging events Open
View article: Safe and stable noninvasive focal gene delivery to the mammalian brain following focused ultrasound
Safe and stable noninvasive focal gene delivery to the mammalian brain following focused ultrasound Open
OBJECTIVE Surgical infusion of gene therapy vectors has provided opportunities for biological manipulation of specific brain circuits in both animal models and human patients. Transient focal opening of the blood-brain barrier (BBB) by MR-…
View article: SCDT-37. MODULATION OF CONVECTION ENHANCED DELIVERY (CED) DISTRIBUTION USING FOCUSED ULTRASOUND (FUS)
SCDT-37. MODULATION OF CONVECTION ENHANCED DELIVERY (CED) DISTRIBUTION USING FOCUSED ULTRASOUND (FUS) Open
INTRODUCTION: Ineffective drug delivery across the blood brain barrier (BBB) is one purported factor that contributes to the lack of therapeutic benefit of systemic chemotherapy for brain tumors. Convection enhanced delivery (CED) is an ap…
View article: The tumor suppressor PTEN regulates motor responses to striatal dopamine in normal and Parkinsonian animals
The tumor suppressor PTEN regulates motor responses to striatal dopamine in normal and Parkinsonian animals Open