Mihai Géorgescu
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View article: miRNA and Its Implications in the Treatment Resistance in Breast Cancer—Narrative Review of What Do We Know So Far
miRNA and Its Implications in the Treatment Resistance in Breast Cancer—Narrative Review of What Do We Know So Far Open
Breast cancer remains a leading cause of cancer-related mortality worldwide, with treatment resistance and tumor heterogeneity posing major clinical challenges. MicroRNAs (miRNAs), small non-coding RNAs regulating gene expression, have eme…
View article: Sustainable, flame-retarded and biodegradable printed circuit boards based on polylactic acid (PLA) with wool-fibre reinforcement: review of processing and manufacturing technologies
Sustainable, flame-retarded and biodegradable printed circuit boards based on polylactic acid (PLA) with wool-fibre reinforcement: review of processing and manufacturing technologies Open
View article: Impact of Chemoradiotherapy on Quality of Life in Cervical Cancer Patients: A Prospective Cohort Study
Impact of Chemoradiotherapy on Quality of Life in Cervical Cancer Patients: A Prospective Cohort Study Open
Background: Cervical cancer is considered to be a global health challenge, particularly in low- and middle-income countries. Romania reports one of the highest burdens in Europe due to limited access to screening and HPV vaccination. Chemo…
View article: Impact of Chemoradiotherapy on Quality of Life in Cervical Cancer Survivors: A Prospective Cohort Study
Impact of Chemoradiotherapy on Quality of Life in Cervical Cancer Survivors: A Prospective Cohort Study Open
Cervical cancer is considered a global health challenge, particularly in low and middle-income countries. Romania reports one of the highest burdens in Europe due to limited access to screening and HPV vaccination. Chemoradiotherapy is sta…
View article: Variation in Immune and Inflammatory Blood Markers in Advanced Melanoma Patients Treated with PD-1 Inhibitors: A Preliminary Exploratory Study
Variation in Immune and Inflammatory Blood Markers in Advanced Melanoma Patients Treated with PD-1 Inhibitors: A Preliminary Exploratory Study Open
Background: Immune checkpoint inhibitors (ICIs) used for the treatment of advanced melanoma have yielded significant results, with long-term responses and improved survival rates, but not for all treated patients. Therefore, predictive bio…
View article: Long-Term Survival in Metachronous Primary Malignancies: Stage III Nasopharyngeal Cancer and Stage IV Non-Small-Cell Lung Cancer
Long-Term Survival in Metachronous Primary Malignancies: Stage III Nasopharyngeal Cancer and Stage IV Non-Small-Cell Lung Cancer Open
Introduction: The occurrence of a second primary lung cancer after head and neck cancer is a challenge for multidisciplinary teams, since the development of a second lung cancer negatively affects the survival rate of patients with head an…
View article: Enhancing Prognosis in Advanced Ovarian Cancer: Primary Cytoreductive Surgery and Adjuvant Chemotherapy or Neoadjuvant Chemotherapy and Interval Cytoreduction—A Single-Center Retrospective Observational Study
Enhancing Prognosis in Advanced Ovarian Cancer: Primary Cytoreductive Surgery and Adjuvant Chemotherapy or Neoadjuvant Chemotherapy and Interval Cytoreduction—A Single-Center Retrospective Observational Study Open
Background: Advanced-stage ovarian cancer presents a significant therapeutic challenge, with primary cytoreductive surgery (PCS) followed by chemotherapy and neoadjuvant chemotherapy (NACT) with interval debulking surgery (IDS) as the two …
View article: Diagnosis and Management of Cancers in Pregnancy: The Results of a Dual Battle Between Oncological Condition and Maternal Environment—Literature Review
Diagnosis and Management of Cancers in Pregnancy: The Results of a Dual Battle Between Oncological Condition and Maternal Environment—Literature Review Open
Cancer during pregnancy presents considerable challenges that arise from various factors, including the diagnostic, prognostic and therapeutic implications of managing cancer in this unique patient population. There is a crucial need for a…
View article: Lymphangioleiomyomatosis and Pregnancy—Do We Have All the Answers for a Woman Who Desires to Conceive?—Literature Review
Lymphangioleiomyomatosis and Pregnancy—Do We Have All the Answers for a Woman Who Desires to Conceive?—Literature Review Open
Lymphangioleiomyomatosis (LAM) is a rare, progressive, and poor-prognosis systemic disorder that primarily affects women of reproductive age, with a higher prevalence among individuals of Caucasian origin. However, there are limited reliab…
View article: Vulvar Metastasis in Renal Cell Carcinoma: A Case Report Highlighting the Aggressive Nature of Clear Cell Renal Cell Carcinoma
Vulvar Metastasis in Renal Cell Carcinoma: A Case Report Highlighting the Aggressive Nature of Clear Cell Renal Cell Carcinoma Open
Vulvar cancer is one of the rarest gynecological malignancies. The development of this condition can be associated with either dysplasia linked to human papillomavirus (HPV), primarily affecting younger women, or vulvar dermatoses such as …
View article: Assessment of psycho-emotional symptoms in cancer patients in an Oncology-Palliative Care Department from Romania
Assessment of psycho-emotional symptoms in cancer patients in an Oncology-Palliative Care Department from Romania Open
Introduction. Anxiety and depression have an increased prevalence in cancer patients, especially in those in an advanced stage of the disease. These disorders have a major impact on the social life, existential concerns and quality of life…
View article: Structural and Thermal Characterization of Some Thermoplastic Starch Mixtures
Structural and Thermal Characterization of Some Thermoplastic Starch Mixtures Open
The paper presents the production of thermoplastic starch (TPS) mixtures using potato starch and two types of plasticizers: glycerol and sorbitol. The effects of plasticizers, citric acid, organically modified montmorillonite clay nanofill…
View article: A Systematic Review of Semaglutide’s Influence on Cognitive Function in Preclinical Animal Models and Cell-Line Studies
A Systematic Review of Semaglutide’s Influence on Cognitive Function in Preclinical Animal Models and Cell-Line Studies Open
Since we aim to test new options to find medication for cognitive disorders, we have begun to assess the effect of semaglutide and to conduct a review gathering studies that have attempted this purpose. This systematic review focuses on th…
View article: Anal Cancer: A Comprehensive Review of Epidemiology, Clinical Manifestations, and Therapeutic Approaches
Anal Cancer: A Comprehensive Review of Epidemiology, Clinical Manifestations, and Therapeutic Approaches Open
In this chapter, we present a comprehensive review of anal cancer, focusing on its epidemiology, clinical manifestations (semiology), and therapeutic approaches. We delve into the global incidence and prevalence rates of anal cancer, explo…
View article: Optimizing Palliative Pelvic Radiotherapy in Gynecological Cancers: A Systematic Review and Analysis
Optimizing Palliative Pelvic Radiotherapy in Gynecological Cancers: A Systematic Review and Analysis Open
Background: Palliative radiotherapy plays a crucial role in managing symptomatic gynecological cancers (GCs). This article aims to systematically review literature studies on palliative pelvic radiotherapy in cervical, endometrial, ovarian…
View article: BIODEGRADABLE POLYMER COMPOSITE BASED ON POLYVINYL CHLORIDE AND WOOD WASTE. DEVELOPMENT AND CHARACTERIZATION
BIODEGRADABLE POLYMER COMPOSITE BASED ON POLYVINYL CHLORIDE AND WOOD WASTE. DEVELOPMENT AND CHARACTERIZATION Open
This work deals with the development and characterization of biodegradable polymer composites based on of polyvinyl chloride (PVC) and wood waste (WW) post-consumer waste. Wood waste resulting from wood processing into finished products is…
View article: Chronic Pelvic Puzzle: Navigating Deep Endometriosis with Renal Complications
Chronic Pelvic Puzzle: Navigating Deep Endometriosis with Renal Complications Open
This case report delves into the intricacies of a challenging clinical scenario involving deep pelvic endometriosis, which manifested with renal complications. Endometriosis, a complex gynecological condition, is explored in this case, hig…
View article: Navigating a Complex Intersection: Immunotherapy and Radiotherapy Synergy in Squamous Cell Carcinoma of the Skin—A Comprehensive Literature Review
Navigating a Complex Intersection: Immunotherapy and Radiotherapy Synergy in Squamous Cell Carcinoma of the Skin—A Comprehensive Literature Review Open
Skin squamous cell carcinoma (SCC) represents a major public health concern due to its high incidence and potential for local invasion and metastasis. Compared to local recurrence, metastatic SCC represents an even greater therapeutic chal…
View article: Cardiovascular Calcifications Are Correlated with Inflammation in Hemodialysis Patients
Cardiovascular Calcifications Are Correlated with Inflammation in Hemodialysis Patients Open
Background and Objectives: The main cause of morbidity and mortality in hemodialysis patients is cardiovascular disease, which is quite common. The main objective of our study was to investigate the relationship between oxidative stress, i…
View article: Influence of Atmospheric Conditions on the Polymer Composite Based on NBR Rubber and Functionalized Protein Waste
Influence of Atmospheric Conditions on the Polymer Composite Based on NBR Rubber and Functionalized Protein Waste Open
Technology has progressed a lot in the last 20 years, today it is possible to obtain new polymer composites that show performance properties. The ever-increasing demand for new high-performance materials has determined the appearance of ne…
View article: The Therapy of Vulvar Carcinoma—Evaluation of Surgical Options in a Retrospective Monocentric Study
The Therapy of Vulvar Carcinoma—Evaluation of Surgical Options in a Retrospective Monocentric Study Open
(1) Background: Surgical-oncological treatment methods are continuously put to the test in times of evidence-based medicine—notably, a constant reevaluation remains key, especially for tumor entities with increasing incidence such as vulva…
View article: Accuracy of Breast Ultrasonography and Mammography in Comparison with Postoperative Histopathology in Breast Cancer Patients after Neoadjuvant Chemotherapy
Accuracy of Breast Ultrasonography and Mammography in Comparison with Postoperative Histopathology in Breast Cancer Patients after Neoadjuvant Chemotherapy Open
Introduction: Nowadays chemotherapy in breast cancer patients is optionally applied neoadjuvant, which allows for testing of tumor response to the chemotherapeutical treatment in vivo, as well as allowing a greater number of patients to be…
View article: The Evolving Landscape of Immunotherapy in Uterine Cancer: A Comprehensive Review
The Evolving Landscape of Immunotherapy in Uterine Cancer: A Comprehensive Review Open
Endometrial cancer affects the uterus and is becoming increasingly common and deadly. Although surgery and adjuvant pelvic radiotherapy can often cure the disease when it is contained in the uterus, patients with metastatic or recurrent di…
View article: The Beginner Laparoscopists Trends in the Learning Process of Laparoscopy for Adnexal Gynecological Pathologies—The Experience of Our Center
The Beginner Laparoscopists Trends in the Learning Process of Laparoscopy for Adnexal Gynecological Pathologies—The Experience of Our Center Open
Background: Laparoscopy for benign ovarian pathology is the appropriate surgical approach and it has many well-known advantages. Minimal invasive gynecological surgery increases the quality of life of the patient. The learning process of l…
View article: Correlation Studies between S100 Protein Level and Soluble MIA or Tissue MelanA and gp100 (HMB45) Expression in Cutaneous Melanoma
Correlation Studies between S100 Protein Level and Soluble MIA or Tissue MelanA and gp100 (HMB45) Expression in Cutaneous Melanoma Open
(1) Background: Cutaneous melanoma (CM) originates from melanocytes and causes 90% of skin cancer deaths; therefore, the comparison of different soluble and tissue markers could be valuable in the detection of melanoma progression and ther…
View article: The Beginner Laparoscopists Trends in the Learning Process Of Laparoscopy for Adnexal Gynecological Pathologies – The Experience of Our Center
The Beginner Laparoscopists Trends in the Learning Process Of Laparoscopy for Adnexal Gynecological Pathologies – The Experience of Our Center Open
Background: Laparoscopy for benign ovarian pathology is the appropriate surgical approach and it has a lot of well-known advantages. Minimal invasive gynecological surgery increases the quality of life for the patient. The learning process…
View article: Biodegradable Polymer Composite Based on Polyvinyl Chloride and Poly (Ethylene-Vinyl Acetate) Waste
Biodegradable Polymer Composite Based on Polyvinyl Chloride and Poly (Ethylene-Vinyl Acetate) Waste Open
This paper presents experiments on developing and characterizing biodegradable polymer composites based on polyvinyl chloride and expanded poly(ethylene vinyl acetate) (EVA) post-consumer waste. This type of waste is a thermoplastic materi…
View article: Surgical Implications in the Pathology of Diabetes Mellitus – Review of the Literature
Surgical Implications in the Pathology of Diabetes Mellitus – Review of the Literature Open
Diabetes mellitus brings together several syndromes, all burdened by a high complexity and with the potential to generate vital impairment. The large number of complications result from the association of high blood glucose level with vasc…
View article: Upstaging and Downstaging in Gliomas—Clinical Implications for the Fifth Edition of the World Health Organization Classification of Tumors of the Central Nervous System
Upstaging and Downstaging in Gliomas—Clinical Implications for the Fifth Edition of the World Health Organization Classification of Tumors of the Central Nervous System Open
In 2021, the 5th edition of the WHO Classification of Tumors of the Central Nervous System (WHO-CNS5) was published as the sixth volume of the international standard for brain and spinal cord tumor classification. The most remarkable pract…
View article: Diagnosis and Treatment Difficulties in a Case of Synchronous Colon Cancer with Ovarian Metastasis and Peritoneal Carcinomatosis
Diagnosis and Treatment Difficulties in a Case of Synchronous Colon Cancer with Ovarian Metastasis and Peritoneal Carcinomatosis Open
We present the case of a 46 year old female patient, with a personal history of breast abscess and total thyroidectomy for multiple thyroid cysts, who was investigated in a different healthcare facility for loss of appetite and weight loss…