Explanipedia

A phase I study of AZD8186 in combination with docetaxel in patients with PTEN-mutated or PIK3CB-mutated advanced solid tumors Open

Alison M. Schram, Naoko Takebe, Anna Chen, Qin Zhou, Alexia Iasonos , et al. · 2025

The combination of AZD8186 and docetaxel was generally well tolerated, with the exception of neutropenia, which was effectively managed with the use of growth factor. Limited clinical activity was observed.

The role of ASPECTS score, atrial fibrillation, and revascularization therapy in predicting hemorrhagic transformation of ischemic stroke: results from a prospective cohort study Open

Elena Costru-Tasnic, Mihail Gavriliuc, Odainic Olesea, Taşnic Mihail, Elena Manole · 2025

Introduction Hemorrhagic transformation (HT) can seriously complicate and worsen the clinical outcome of acute ischemic stroke (AIS) patients. Atrial fibrillation (AF), larger stroke volumes, and reperfusion therapy are associated with inc…

Methodology of remote ischemic conditioning in patients with cerebral cardioembolism Open

Rodica Luchianciuc, Mihail Gavriliuc · 2025

In recent years, the treatment of acute ischemic stroke has seen significant progress due to the increased use of intravenous thrombolysis and mechanical thrombectomy. This article examines whether non-pharmacological neuroprotective thera…

Anatomical features of the mastoid segment of the facial canal Open

Angela Babuci, Laila Ashkar, Zinovia Zorina, Ilia Catereniuc, Mihail Gavriliuc , et al. · 2024

In otologic surgery, particularly in mastoidectomy, it should be taken into consideration that the mastoid segment of the facial canal could exit the temporal bone at sharp, right and obtuse angles. This peculiarity, along with high morpho…

Model predicting the onset of antiepileptic drug resistance in women of reproductive age with epilepsy: analytical study Open

Victoria Duca, Mihail Gavriliuc · 2023

Introduction. In attempt to find an answer regarding the possible scenarios of epilepsy evolution in women of reproductive age (e.g. worsening, remission, antiepileptic drug resistance, status epilepticus occurence), preferably - objective…

Serum biomarkers to predict hemorrhagic transformation and ischemic stroke outcomes in a prospective cohort study Open

Elena Costru-Tasnic, Mihail Gavriliuc, Elena Manole · 2023

Ischemic stroke (IS) remains one of the most frequent causes of death and disability worldwide. Identifying possible prognosis factors for IS outcomes, including hemorrhagic transformation (HT), could improve patients' recovery. This study…

P-31 A phase I/II trial investigating safety and efficacy of autologous TAC01-HER2 in relapsed or refractory solid tumors Open

Ecaterina E. Dumbrava, Daniel J. Olson, M. George, S. Saibil, Antonio Gasbarrini , et al. · 2023

Greeting letter Professor Gavriliuc 2022 Open

Mihail Gavriliuc · 2022

Greeting letter Professor Gavriliuc 2022

Essential tremor- diagnostic criteria and treatment modalities Open

Olga Gavriliuc, Paula Fala, Mihail Gavriliuc, Alexandru Andrușca · 2022

Essential tremor (EЕ) is the most common cause of action tremor in adults. In most cases, TE can be managed by primary care physicians, starting with the exclusion of secondary causes and followed by initiation of propranolol or primidone …

Comorbidities in patients with Parkinson's disease Open

Anastasia Caldarov, Olga Gavriliuc, Lilia Rotaru, Alexandru Andrușca, Paula Fala , et al. · 2022

A wide spectrum of comorbidities has been associated with Parkinson’s disease (PD), a progressive neurodegenerative disease that affects more than seven million people worldwide. Emerging evidence indicates that chronic diseases including …

Low-dose anticholinergic therapy causes cognitive impairment in Parkinson's disease patients Open

Olga Gavriliuc, Alexandru Andrușca, Lilian Popil, Mihail Gavriliuc · 2021

Background: Before L-Dopa’s discovery, anticholinergic drugs were among the first treatments for Parkinson’s disease. Only now trihexyphenidyl (THP) is approved to treat unresponsive L-dopa tremors in young, cognitively unaffected Parkinso…

The importance of matrix metalloproteinases in the prognosis of acute ischemic stroke patients Open

Elena Costru-Tasnic, Mihail Gavriliuc, Elena Manole · 2021

Ischemic stroke is one of the leading causes of mortality and disability worldwide. Numerous studies were performed to assess the risk of clinical deterioration of acute ischemic stroke patients, including the risk of haemorrhagic transfor…

Pregnancy in multiple sclerosis: from scientific aspects to practical Open

Anna Belenciuc, Ana-Maria Bubuioc, Olesea Odainic, Marina Sangheli, Mihail Gavriliuc , et al. · 2021

Background: Multiple sclerosis (MS) is a disease that affects young people of reproductive age (20-40 years old), predominantly women. Therefore, almost every patient has questions about pregnancy and breastfeeding. Family planning is one …

Overview of vascular dementia Open

Mihail Gavriliuc · 2021

NORMAL PRESSURE HYDROCEPHALUS: LITERATURE REVIEW Open

Paula Fala, Victor Andronachi, Mihail Gavriliuc, Pavel Gavriliuc, Alexandru Andrușca , et al. · 2020

Objectives. Normal pressure hydrocephalus is a potentially reversible disease, characterized by a pathological enlargement of the cerebral ventricles, with a normal opening pressure during the lumbar puncture. The characteristic triad of N…

ENHANCEMENT OF PREOPERATIVE NEUROSURGICAL PLANNING, USING 3D SEGMENTATION MODELS Open

Andrușca Alexandru, Andronachi Victor, Mihail Gavriliuc, Olga Gavriliuc, Pavel Gavriliuc · 2020

Objectives. The vertiginous, progressive development of the contemporary imaging techniques, such as computed tomography and magnetic resonance imaging, apparently led to an increase in the information volume, provided about anatomical str…

White matter hyper-intensity patters in patients with amyloid angiopathy and cerebellum involvement Open

Pavel Gavriliuc, Mihail Gavriliuc, Stanislav Groppa, Ronen R. Leker · 2020

Background: Pathological changes in the cerebral white matter can be determined both in small vessel disease and in cerebral amyloid angiopathy. The \npattern of involvement may be different depending on the etiology and severity of the pr…

Clinical indicators of gait freezing in Parkinson's disease Open

Olga Gavriliuc, Alexandru Andrușca, Mihail Gavriliuc · 2020

<p><strong>Background:</strong> Freezing of gait is a common (FOG) episodic gait disorder in advanced Parkinson's disease (PD). FOG is one of the main risk factors for falls; therefore FOG’s consequences can be …

WHITE MATTER HYPER-INTENSITY PATTERNS IN PATIENTS WITH AMYLOID ANGIOPATHY AND CEREBELLUM INVOLVEMENT Open

Pavel Gavriliuc, Mihail Gavriliuc, Groppa Stanislav, Leker Ronen · 2020

Actualităţi în angiopatia amiloidă cerebrală Open

Mihail Gavriliuc, Leker Ronen, Pavel Gavriliuc · 2017

Erratum Open

Nicola Vanacore, Emanuele Rastelli, Giovanni Antonini, Maria Laura Ester Bianchi, Annalisa Botta , et al. · 2016

Prevalence of Multiple Sclerosis in the Republic of Moldova Open

Cristina Marcoci, Vitalie Lisnic, Mihail Gavriliuc, Olesea Odainic, Sangheli Marina , et al. · 2016

Background: The occurrence of multiple sclerosis (MS) increases in populations featuring both high and low disease burden, and variations across regions at the same latitude are reported. MS epidemiological data in Eastern Eu…

Assessment of risk factors for haemorrhagic transformation in ischemic stroke patients Open

Elena Costru-Tasnic, Mihail Gavriliuc, Vitalie Lisnic · 2015

Background: The haemorrhagic transformation (HT) is one of the most feared complications in ischemic stroke (IS) patients, especially in those submitted to thrombolysis treatment. Older age, male gender, high blood pressure (HBP), admissio…

Caz clinic: scleroza laterală amiotrofică cu debut precoce Open

Mihail Gavriliuc, Şalari Natalia, Manole Elena, Filioglo Andrei, Olga Gavriliuc · 2015

Cercetarea perspectivelor de tratament prin metoda de stimulare cerebrală profundă la pacienții cu maladia Parkinson Open

Alexandru Andrușca, Mihail Gavriliuc · 2015

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