Miho Koizumi
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View article: JMJD3-mediated senescence is required to overcome stress-inducedhematopoietic defects
JMJD3-mediated senescence is required to overcome stress-inducedhematopoietic defects Open
Cellular senescence in stem cells compromises regenerative capacity, promotes chronic inflammation, and is implicated in aging. Hematopoietic stem and progenitor cells (HSPCs) are responsible for producing mature blood cells, however, how …
View article: Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice
Rspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice Open
The unique architecture of the liver consists of hepatic lobules, dividing the hepatic features of metabolism into 2 distinct zones, namely the pericentral and periportal zones, the spatial characteristics of which are broadly defined as m…
View article: PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1
PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1 Open
The genome is constantly exposed to DNA damage from endogenous and exogenous sources. Fine modulation of DNA repair, chromatin remodeling, and transcription factors is necessary for protecting genome integrity, but the precise mechanisms a…
View article: Elevated stress response marks deeply quiescent reserve cells of gastric chief cells
Elevated stress response marks deeply quiescent reserve cells of gastric chief cells Open
View article: MBTD1 preserves adult hematopoietic stem cell pool size and function
MBTD1 preserves adult hematopoietic stem cell pool size and function Open
Mbtd1 (mbt domain containing 1 ) encodes a nuclear protein containing a zinc finger domain and four malignant brain tumor (MBT) repeats. We previously generated Mbtd1 -deficient mice and found that MBTD1 is highly expressed in fetal hemato…
View article: Data from <i>Kdm6a</i> Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with <i>p53</i> Dysfunction
Data from <i>Kdm6a</i> Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with <i>p53</i> Dysfunction Open
Purpose:Epigenetic deregulation is deeply implicated in the pathogenesis of bladder cancer. KDM6A (Lysine (K)-specific demethylase 6A) is a histone modifier frequently mutated in bladder cancer. However, the molecular mechanisms of how KDM…
View article: Data from <i>Kdm6a</i> Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with <i>p53</i> Dysfunction
Data from <i>Kdm6a</i> Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with <i>p53</i> Dysfunction Open
Purpose:Epigenetic deregulation is deeply implicated in the pathogenesis of bladder cancer. KDM6A (Lysine (K)-specific demethylase 6A) is a histone modifier frequently mutated in bladder cancer. However, the molecular mechanisms of how KDM…
View article: Supplementary Data from <i>Kdm6a</i> Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with <i>p53</i> Dysfunction
Supplementary Data from <i>Kdm6a</i> Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with <i>p53</i> Dysfunction Open
Supplementary Information: Tables S1, S2, S3, S4 (gene set enrichment analyses); Figures S1, S2, S3, S4
View article: Supplementary Data from <i>Kdm6a</i> Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with <i>p53</i> Dysfunction
Supplementary Data from <i>Kdm6a</i> Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with <i>p53</i> Dysfunction Open
Supplementary Information: Tables S1, S2, S3, S4 (gene set enrichment analyses); Figures S1, S2, S3, S4
View article: Aberrant <i>EVI1</i> splicing contributes to <i>EVI1</i>-rearranged leukemia
Aberrant <i>EVI1</i> splicing contributes to <i>EVI1</i>-rearranged leukemia Open
Detailed genomic and epigenomic analyses of MECOM (the MDS1 and EVI1 complex locus) have revealed that inversion or translocation of chromosome 3 drives inv(3)/t(3;3) myeloid leukemias via structural rearrangement of an enhancer that upreg…
View article: UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes
UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes Open
Epigenetic regulation is essential for the maintenance of the hematopoietic system, and its deregulation is implicated in hematopoietic disorders. In this study, UTX, a demethylase for lysine 27 on histone H3 (H3K27) and a component of COM…