Miho Shimari
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View article: Dietary Nitrate Prevents Cardiac Dysfunction in <scp>HFrEF</scp> by Improving Hemodynamics, Ameliorating Remodeling, and Resolving Inflammation
Dietary Nitrate Prevents Cardiac Dysfunction in <span>HFrEF</span> by Improving Hemodynamics, Ameliorating Remodeling, and Resolving Inflammation Open
Aims Impaired cardiac function, reduced nitric oxide (NO) bioavailability, and inflammation are key contributors to the pathogenesis and progression of heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate w…
View article: Protective Effects of the Food Supplement Flexovital in a Model of Cardiovascular-Kidney-Metabolic Syndrome in Mice
Protective Effects of the Food Supplement Flexovital in a Model of Cardiovascular-Kidney-Metabolic Syndrome in Mice Open
Background/Objectives: The prevalence of cardiovascular-kidney-metabolic (CKM) syndrome is increasing rapidly, and cardiovascular complications pose significant risks in individuals with kidney disease and metabolic dysfunction. Understand…
View article: A novel model of cardiovascular–kidney–metabolic syndrome combining unilateral nephrectomy and high-salt–sugar–fat diet in mice
A novel model of cardiovascular–kidney–metabolic syndrome combining unilateral nephrectomy and high-salt–sugar–fat diet in mice Open
The aim of this study was to explore biological interaction and pathophysiology mechanisms in a new mouse model of cardiovascular–kidney–metabolic (CKM) syndrome, induced by chronic moderate renal failure in combination with consumption of…
View article: Use of an Antibacterial Mouthwash Alters the Gut Microbiome, Reduces Nutrient Absorption and Attenuates Diet-induced Obesity
Use of an Antibacterial Mouthwash Alters the Gut Microbiome, Reduces Nutrient Absorption and Attenuates Diet-induced Obesity Open
Prolonged use of antibacterial mouthwash is linked to increased risk of systemic disease. We aimed to investigate if disturbing the oral microbiota would impact the lower gut microbiome with functional effects in diet-induced obesity. Mice…
View article: Angiotensin II type 1 receptor antagonist restores dysfunction of vascular reactivity independent of perivascular adipose tissue-mediated mechanisms in rats with metabolic syndrome
Angiotensin II type 1 receptor antagonist restores dysfunction of vascular reactivity independent of perivascular adipose tissue-mediated mechanisms in rats with metabolic syndrome Open
Perivascular adipose tissue (PVAT) regulates vascular tone.We demonstrated that PVAT masks impaired vasodilation in the mesenteric arteries of SHRSP.Z-Lepr fa /IzmDmcr rats (SHRSP.ZF) with metabolic syndrome (MetS); however, this enhanced …
View article: Influence of perivascular adipose tissue on vasodilation in the renal artery of metabolic syndrome rats
Influence of perivascular adipose tissue on vasodilation in the renal artery of metabolic syndrome rats Open
Perivascular adipose tissue (PVAT) is known to modulate vascular tone. We have demonstrated that impaired vasodilation is masked by the presence of PVAT at 20 weeks of age (wks) in the mesenteric arteries of SHRSP.Z-Leprfa/IzmDmcr rats (SH…
View article: Apelin intensifies vascular relaxation through activation of the endothelial nitric oxide production pathway in rats with metabolic syndrome
Apelin intensifies vascular relaxation through activation of the endothelial nitric oxide production pathway in rats with metabolic syndrome Open
Perivascular adipose tissue (PVAT) modulates the vascular tone.We previously demonstrated that mesenteric arterial PVAT enhances vasodilation in SHRSP.Z-Leprfa/IzmDmcr (SHRSP.ZF) rats.However, the factors involved in the vasodilation effec…
View article: Perivascular Adipose Tissue-Enhanced Vasodilation in Metabolic Syndrome Rats by Apelin and N-Acetyl–l-Cysteine-Sensitive Factor(s)
Perivascular Adipose Tissue-Enhanced Vasodilation in Metabolic Syndrome Rats by Apelin and N-Acetyl–l-Cysteine-Sensitive Factor(s) Open
Perivascular adipose tissue (PVAT) can regulate vascular tone. In mesenteric arteries of SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP.ZF) with metabolic syndrome, vascular dysfunction is compensated by PVAT-dependent mechanisms that disappear with i…
View article: Characteristics of effects of perivascular adipose tissue on vasodilation in metabolic syndrome rats
Characteristics of effects of perivascular adipose tissue on vasodilation in metabolic syndrome rats Open
Perivascular adipose tissue (PVAT) modulates vascular tone. Abdominal obesity and metabolic syndrome, with increased PVAT volume, increase the risk of cardiovascular disease. We reported previously that impaired vasodilation in response to…