Explanipedia

Translatome profiling reveals <i>Itih4</i> as a novel smooth muscle cell–specific gene in atherosclerosis Open

Aarthi Ravindran, Lari Holappa, Henri Niskanen, Ilya Skovorodkin, Susanna Kaisto , et al. · 2024

Aims Vascular smooth muscle cells (SMCs) and their derivatives are key contributors to the development of atherosclerosis. However, studying changes in SMC gene expression in heterogeneous vascular tissues is challenging due to the technic…

ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component Open

Suvi Jauhiainen, Henna Ilmonen, Pia Vuola, Heta Rasinkangas, H. H. Pulkkinen , et al. · 2023

Background: Sporadic venous malformation (VM) and angiomatosis of soft tissue (AST) are benign, congenital vascular anomalies affecting venous vasculature. Depending on the size and location of the lesion, symptoms vary from motility distu…

Author response: ErbB signaling is a potential therapeutic target for vascular lesions with fibrous component Open

Suvi Jauhiainen, Henna Ilmonen, Pia Vuola, Heta Rasinkangas, H. H. Pulkkinen , et al. · 2023

Full text Figures and data Side by side Abstract Editor's evaluation Introduction Materials and methods Results Discussion Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstr…

Dissecting the polygenic basis of atherosclerosis via disease-associated cell state signatures Open

Tiit Örd, Tapio Lönnberg, Valtteri Nurminen, Aarthi Ravindran, Henri Niskanen , et al. · 2023

Coronary artery disease (CAD) is a pandemic disease where up to half of the risk is explained by genetic factors. Advanced insights into the genetic basis of CAD require deeper understanding of the contributions of different cell types, mo…

Nondestructive Evaluation of Mechanical and Histological Properties of the Human Aorta With Near-Infrared Spectroscopy Open

Jaakko K. Sarin, Miika Kiema, Emma-Sofia Luoto, Annastiina Husso, Marja Hedman , et al. · 2023

NIRS could be a potential technique for in situ evaluation of biomechanical and histological properties of human aorta and therefore useful in patient-specific treatment planning.

ErbB Signalling is a Potential Therapeutic Target for Vascular Lesions with Fibrous Component Open

Henna Ilmonen, Suvi Jauhiainen, Pia Vuola, Heta Rasinkangas, H. H. Pulkkinen , et al. · 2022

Background: Sporadic venous malformation (VM) and angiomatosis of soft tissue (AST) are benign, congenital vascular anomalies affecting venous vasculature. Depending on the size and location of the lesion, symptoms vary from motility distu…

Wall Shear Stress Predicts Media Degeneration and Biomechanical Changes in Thoracic Aorta Open

Miika Kiema, Jaakko K. Sarin, S. Petteri Kauhanen, Jari Torniainen, Hanna Matikka , et al. · 2022

Objectives: In thoracic aortic aneurysm (TAA) of the ascending aorta (AA), AA is progressively dilating due to the weakening of the aortic wall. Predicting and preventing aortic dissections and ruptures in TAA continues to be challenging, …

Dissecting the polygenic basis of atherosclerosis using disease associated cell state signatures Open

Tiit Örd, Tapio Lönnberg, Aarthi Ravindran, Henri Niskanen, Miika Kiema , et al. · 2022

Coronary artery disease (CAD) is a pandemic disease where up to half of the risk is explained by genetic factors. Advanced insights into genetic basis of CAD require deeper understanding of the contributions of different cell types, molecu…

Large Vessel Cell Heterogeneity and Plasticity: Focus in Aortic Aneurysms Open

Suvi Jauhiainen, Miika Kiema, Marja Hedman, Johanna P. Laakkonen · 2022

Smooth muscle cells and endothelial cells have a remarkable level of plasticity in vascular pathologies. In thoracic and abdominal aortic aneurysms, smooth muscle cells have been suggested to undergo phenotypic switching and to contribute …

BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF Open

H. H. Pulkkinen, Miika Kiema, Jari P. Lappalainen, Anu Toropainen, Mustafa Beter , et al. · 2020

Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells Open

Oscar Hsin-Fu Liu, Miika Kiema, Mustafa Beter, Seppo Ylä‐Herttuala, Johanna P. Laakkonen , et al. · 2020

Objective: Previous studies have demonstrated that the expression of several lysine (K)-specific demethylases (KDMs) is induced by hypoxia. Here, we sought to investigate the exact mechanisms underlying this regulation and its functional i…

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