Mikael Rørdam Andersen
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View article: Section-level genome sequencing and comparative genomics of <i>Aspergillus</i> sections <i>Cavernicolus</i> and <i>Usti</i>
Section-level genome sequencing and comparative genomics of <i>Aspergillus</i> sections <i>Cavernicolus</i> and <i>Usti</i> Open
The genus Aspergillus is diverse, including species of industrial importance, human pathogens, plant pests, and model organisms. Aspergillus includes species from sections Usti and Cavernicolus , which until recently were joined in section…
View article: Section-level genome sequencing and comparative genomics of Aspergillus sections Cavernicolus and Usti
Section-level genome sequencing and comparative genomics of Aspergillus sections Cavernicolus and Usti Open
The genus Aspergillus is diverse, including species of industrial importance, human pathogens, plant pests, and model organisms. Aspergillus includes species from sections Usti and Cavernicolus , which until recently were joined in section…
View article: Comparative genomics of Aspergillus nidulans and section Nidulantes
Comparative genomics of Aspergillus nidulans and section Nidulantes Open
Aspergillus nidulans is an important model organism for eukaryotic biology and the reference for the section Nidulantes in comparative studies. In this study, we de novo sequenced the genomes of 25 species of this sect…
View article: Genomic Analysis of Aspergillus Section Terrei Reveals a High Potential in Secondary Metabolite Production and Plant Biomass Degradation
Genomic Analysis of Aspergillus Section Terrei Reveals a High Potential in Secondary Metabolite Production and Plant Biomass Degradation Open
Aspergillus terreus has attracted interest due to its application in industrial biotechnology, particularly for the production of itaconic acid and bioactive secondary metabolites. As related species also seem to possess a prosperous secon…
View article: Safety aspects of microorganisms deliberately released into the environment
Safety aspects of microorganisms deliberately released into the environment Open
Microorganisms are used in a variety of sectors, including food and feed production, agricultural or environmental applications, and can be optimized for efficacy, safety and sustainability using modern biotechnology techniques. In the EU,…
View article: Identification of novel miRNA targets in CHO cell lines and characterization of their impact on protein N-glycosylation
Identification of novel miRNA targets in CHO cell lines and characterization of their impact on protein N-glycosylation Open
CHO cell lines are a workhorse for the production of pharmaceutical proteins, but show some limitations in the variability and stability of N-glycosylation profiles. One promising approach to addressing this at the required systems-level i…
View article: Use of novel cystine analogs to decrease oxidative stress and control product quality
Use of novel cystine analogs to decrease oxidative stress and control product quality Open
Continuous improvements of cell culture media are required in order to ensure high yield and product quality. However, some components can be instable and lead to detrimental effects on bioprocess performances. l-cysteine is an essential a…
View article: Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis
Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis Open
Glutathione (GSH) plays a central role in the redox balance maintenance in mammalian cells. Previous studies of industrial Chinese hamster ovary cell lines have demonstrated a relationship between GSH metabolism and clone productivity. How…
View article: Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis.
Characterization of glutathione proteome in CHO cells and its relationship with productivity and cholesterol synthesis. Open
Glutathione (GSH) plays a central role in the redox balance maintenance in mammalian cells. The study of industrial CHO cell lines have demonstrated a close link between GSH metabolism and clone productivity. However, a deep investigation …
View article: A comparative genomics study of 23 Aspergillus species from section Flavi
A comparative genomics study of 23 Aspergillus species from section Flavi Open
View article: Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties
Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties Open
The identification of molecules that can modulate RNA or protein function and the subsequent chemical and structural optimization to refine such molecules into drugs is a key activity in drug discovery. Here, we explored the extent to whic…
View article: Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells
Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells Open
Large scale biopharmaceutical production of biologics relies on the overexpression of foreign proteins by cells cultivated in stirred tank bioreactors. It is well recognized and documented fact that protein overexpression may impact host c…
View article: Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli Open
View article: Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion
Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion Open
Chinese hamster ovary (CHO) cells are the preferred host for producing biopharmaceuticals. Amino acids are biologically important precursors for CHO metabolism; they serve as building blocks for proteogenesis, including synthesis of biomas…
View article: Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers Open
View article: Genetic engineering approaches to improve posttranslational modification of biopharmaceuticals in different production platforms
Genetic engineering approaches to improve posttranslational modification of biopharmaceuticals in different production platforms Open
The number of approved biopharmaceuticals, where product quality attributes remain of major importance, is increasing steadily. Within the available variety of expression hosts, the production of biopharmaceuticals faces diverse limitation…
View article: Strategies to establish the link between biosynthetic gene clusters and secondary metabolites
Strategies to establish the link between biosynthetic gene clusters and secondary metabolites Open
Filamentous fungi produce a vast number of bioactive secondary metabolites (SMs), some of which have found applications in the pharmaceutical industry including as antibiotics and immunosuppressants. As more and more species are whole geno…
View article: Resistance Gene-Directed Genome Mining of 50 <i>Aspergillus</i> Species
Resistance Gene-Directed Genome Mining of 50 <i>Aspergillus</i> Species Open
Species belonging to the Aspergillus genus are known to produce a large number of secondary metabolites; some of these compounds are used as pharmaceuticals, such as penicillin, cyclosporine, and statin. With whole-genome sequencing, it be…
View article: Fungal Resistance gene-directed genome mining (FRIGG) pipeline
Fungal Resistance gene-directed genome mining (FRIGG) pipeline Open
Fungal secondary metabolites are a rich source of valuable natural products, and genome sequencing has revealed a proliferation of predicted biosynthetic gene clusters in the genomes. It is however currently an unfeasible task to character…
View article: MOESM3 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
MOESM3 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli Open
Additional file 3 List of collections of identical sequences from Additional file 2.
View article: MOESM2 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
MOESM2 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli Open
Additional file 2 ML phylogeny of KS-domains of PKS, PKS-like and hybrid proteins in Aspergilli.
View article: MOESM7 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
MOESM7 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli Open
Additional file 7 Data frame for A-domain tree in additional file 6.
View article: MOESM1 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
MOESM1 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli Open
Additional file 1 ML phylogeny of NRPS-PKS and PKS-NRPS hybrids in Aspergilli.
View article: MOESM5 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
MOESM5 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli Open
Additional file 5 Data frame for A-domain tree in additional file 4.
View article: MOESM4 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
MOESM4 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli Open
Additional file 4 ML phylogeny of A domains of NRPS, NRPS-like and hybrid proteins in Aspergilli.
View article: MOESM8 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
MOESM8 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli Open
Additional file 8 NCBI identifier to taxonomical class translation table.
View article: MOESM6 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
MOESM6 of Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli Open
Additional file 6 ML phylogeny of Aspergillus A-domains of hybrid proteins and hybrid proteins from best hit analysis against the non-redundant protein database.
View article: Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication
Uncovering secondary metabolite evolution and biosynthesis using gene cluster networks and genetic dereplication Open
View article: Resistance Gene-Directed Genome Mining of 50 Aspergillus species
Resistance Gene-Directed Genome Mining of 50 Aspergillus species Open
Fungal secondary metabolites are a rich source of valuable natural products. Genome sequencing have revealed an enormous potential from predicted biosynthetic gene clusters. It is however currently a time consuming task and an unfeasible t…
View article: Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri
Investigation of inter- and intraspecies variation through genome sequencing of Aspergillus section Nigri Open