Explanipedia

Fostamatinib and the risk of acute aortic dissection in immune thrombocytopenia Open

Paul Dalmas, Alexis Théron, Rita Badaoui, Stéphane Zaffran, Rayid Mchinda , et al. · 2025

Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by platelet destruction. While most patients respond to first‐ or second‐line therapies, a small subset is multirefractory. Fostamatinib , an oral spleen tyrosine ki…

Cold Agglutinin Syndrome Secondary to Mycoplasma pneumoniae Infection in Adults: Results From a Large French Observational Study (MyCOLD Study) Open

Kévin Chevalier, Michal Holub, Romain Palich, K. Blanckaert, Laurent Gilardin , et al. · 2025

Mycoplasma pneumoniae ( MP ), primarily a respiratory pathogen, can cause extra‐pulmonary manifestations including cold agglutinin syndrome (CAS). We conducted a national, multicenter, observational, ambispective study to describe the char…

Whole Exome Sequencing of Adult Patients With Evans Syndrome Reveals Pathogenic Variants Associated With Autoimmunity Open

Étienne Crickx, Jehane Fadlallah, Morgane Cheminant, Jérémie Rosain, Jérémie Dion , et al. · 2025

Correction: Neurological manifestations in patients with VEXAS syndrome Open

Charlotte Bert-Marcaz, Étienne Fortanier, Antoine Briantais, B. Faucher, R. Bourguiba , et al. · 2025

C3 Glomerulonephritis Associated With Unusual IgG4 Antifactor H in IgG4-related Disease Open

Paul Dalmas, Mickaël Bobot, Noémie Jourde‐Chiche, Julie Bruno, Stéphane Burtey , et al. · 2025

Case report: A severe myositis mimicking bulbar palsy after administration of immune checkpoint inhibitors Open

Philippe Rochigneux, Antonella Bertucci, Elika Loir, A. Mattei, Daniel Robert , et al. · 2025

Objectives Immune Checkpoint Inhibitors (ICI) are nowadays a cornerstone of anti-cancer treatments. However, the wide spectrum of immune-related adverse events (irAEs) represents a challenge in the oncological practice. Our objective is to…

Efficacy and safety of dapsone in adult primary immune thrombocytopenia Open

Marion Larue, Guillaume Moulis, Manuela Rueter, Sylvain Audia, Louis Terriou , et al. · 2025

To assess efficacy and safety of dapsone in adult immune thrombocytopenia (ITP), a multicenter randomized controlled trial (RCT) and a real-world cohort study were performed. Participants were adults with primary ITP, transient response to…

French protocol for diagnosis and management of Cogan's syndrome Open

Laurent Arnaud, Alexandra Audemard‐Verger, Alexandre Bélot, Boris Bienvenu, C Burillon , et al. · 2024

Deciphering the Presentation and Etiologies of Hypophysitis Highlights the Need for Repeated Systematical Investigation Open

Laura Miquel, Benoît Testud, F. Albarel, Nicolas Sahakian, Thomas Cuny , et al. · 2024

Context Hypophysitis is defined as an inflammation of the pituitary gland and/or infundibulum. Objective Our aim was to characterize the initial course and evolution of patients with hypophysitis according to the different etiologies. Meth…

The CARMEN-France registry of adult patients with immune thrombocytopenia and autoimmune hemolytic anemia in France Open

Guillaume Moulis, Marc Michel, Bernard Bonnotte, Bertrand Godeau, Félix Ackermann , et al. · 2024

Human epicardial adipose tissue contains innate and adaptive lymphoid cells and a higher proportion of innate type 2 lymphoid cells compared to other adipose tissues Open

Elisa Doukbi, Patricia Ancel, Anne Dutour, Astrid Soghomonian, Shaista Ahmed , et al. · 2024

Ibrutinib and Neurolisteriosis: Simple Coincidence? Open

Paul Dalmas, Coline Mortier, Margaux Froidefond, Barbara Doudier, P. Dudouet , et al. · 2024

Listeria monocytogenes is an opportunistic food-borne pathogen that can cross the blood–brain barrier and infect the central nervous system, causing potentially life-threatening neurolisteriosis, including brain abscess. Ibrutinib is a pot…

Human epicardial fat has a beige profile and contains higher type 2 innate lymphoid cells than subcutaneous fat Open

Elisa Doukbi, Patricia Ancel, Anne Dutour, Astrid Soghomonian, Shaista Ahmed , et al. · 2024

Objective Epicardial adipose tissue (EAT) is a visceral fat that has been associated with coronary artery disease and atrial fibrillation. Previous work has revealed that EAT exhibits beige features. Methods First, a new pan‐genomic microa…

Ophthalmic vascular manifestations in eosinophil-associated diseases: a comprehensive analysis of 57 patients from the CEREO and EESG networks and a literature review Open

Elisa Chapuis, Elodie Bousquet, Jean‐François Viallard, Benjamin Terrier, Zahir Amoura , et al. · 2024

Introduction Eosinophils have widespread procoagulant effects. In daily practice, eosinophil-related cardiovascular toxicity consists of endomyocardial damage, eosinophilic vasculitis and arterial or venous thrombosis. Here we aim to repor…

Cyclophosphamide vs rituximab for eradicating inhibitors in acquired hemophilia A: A randomized trial in 108 patients Open

H. Lévesque, Jean‐François Viallard, Estelle Houivet, Bernard Bonnotte, Sophie Voisin , et al. · 2024

gov number: NCT01808911.

Difficult‐to‐treat primary immune thrombocytopenia in adults: Prevalence and burden. Results from the CARMEN‐France registry Open

Guillaume Moulis, Manuela Rueter, Aymeric Duvivier, Matthieu Mahévas, Jean‐François Viallard , et al. · 2024

Summary The aim of this study was to assess the prevalence and the burden of difficult‐to‐treat primary ITP (pITP), defined by the need for another ITP treatment after romiplostim and eltrombopag. Adult patients were selected in the prospe…

Dramatic response to intravenous immunoglobulin in erythroblastic synartesis Open

Clara Fontenaille, B. De Sainte Marie, Marie Loosveld, Mikaël Ebbo, N. Schleinitz · 2023

A 38-year-old man with no previous medical history was admitted to the hospital with an altered general condition. Biological tests revealed non-regenerative anaemia (haemoglobin [Hb] 5.3 g/dL, mean corpuscular volume 83.3 fL, reticulocyte…

Benralizumab for eosinophilic granulomatosis with polyangiitis Open

A. Cottu, Matthieu Groh, Charlene Desaintjean, S. Marchand‐Adam, Loı̈c Guillevin , et al. · 2023

P1613: REAL-WORLD USE OF FOSTAMATINIB IN FRANCE. INTERIM RESULTS OF A NATIONAL REGISTRY. Open

Guillaume Moulis, Matthieu Mahévas, Jean‐François Viallard, Sylvain Audia, Mikaël Ebbo , et al. · 2023

Topic: 32. Platelet disorders Background: Fostamatinib, a spleen tyrosine kinase inhibitor, has been marketed in France for the management of adult chronic immune thrombocytopenia (ITP) in October 2021. French authorities recommended the u…

Severe SARS‐CoV‐2 infection in rituximab‐treated patients with autoimmune cytopenia: A multicenter observational study Open

Boris Sorin, L. Gaigne, Margaux Garzaro, Guillaume Moulis, Arthur Mageau , et al. · 2023

Rituximab (RTX), a monoclonal anti-CD20 antibody targeting B cells, is one of the main therapies for many autoimmune diseases, including immune thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). During the first waves of the CO…

Clinical and Prognostic Factors in Patients with IgG4-Related Kidney Disease Open

Anis Chaba, Arnaud Devresse, Vincent Audard, J.J. Boffa, Alexandre Karras , et al. · 2023

Background IgG4-related kidney disease is a major manifestation of IgG4-related disease, a systemic fibroinflammatory disorder. However, the clinical and prognostic kidney-related factors in patients with IgG4-related kidney disease are in…

Incidence et facteurs de risque d’infection sévère à SARS-CoV-2 chez les patients traités par rituximab pour une cytopénie auto-immune : étude rétrospective multicentrique de 222 patients Open

Boris Sorin, L. Gaigne, Margaux Garzaro, F. Roy-Péaud, P.Y. Jeandel , et al. · 2023

Combining thrombopoietin receptor agonists with immunosuppressive drugs in adult patients with multirefractory immune thrombocytopenia, an update on the French experience Open

Étienne Crickx, Mikaël Ebbo, Étienne Rivière, O. Souchaud-Debouverie, Louis Terriou , et al. · 2023

Summary Combining drugs could be an effective option for treating multirefractory ITP, that is, patients not responding to rituximab, thrombopoietin receptor agonists (TPO‐RA) and splenectomy. We conducted a retrospective, multicenter, obs…

Efficacy and safety of two rituximab biosimilars for treating immune thrombocytopenia: a reference-product matched study Open

Arthur Mageau, Bernard Bonnotte, Mikaël Ebbo, Antoine Dossier, Lionel Galicier , et al. · 2023

The emergence of rituximab biosimilars offers the prospect of significant savings to the healthcare system. However, these drugs have never been evaluated for treating immune thrombocytopenia (ITP). This was an observational, matched study…

Implication of allergy and atopy in IgG4-related disease Open

Katherine D’Astous-Gauthier, Mikaël Ebbo, Pascal Chanez, N. Schleinitz · 2023

Cyclophosphamide vs Rituximab for Eradicating Inhibitors in Acquired Hemophilia A: A Randomized Trial in 108 Patients Open

H. Lévesque, Jean‐François Viallard, Estelle Houivet, Bernard Bonnotte, Sophie Voisin , et al. · 2023

Thoracic manifestations of IgG4‐related disease Open

R. Müller, Mikaël Ebbo, Paul Habert, Laurent Daniel, Antoine Briantais , et al. · 2022

Immunoglobulin G4‐related disease (IgG4‐RD) is a recently described rare systemic fibroinflammatory disease with an estimated incidence of less than 1 in 100,000 persons per year. The disease can affect virtually any organ and is character…

Clinical and pathological features of cutaneous manifestations in VEXAS syndrome: A multicenter retrospective study of 59 cases Open

Ève Zakine, Loula Papageorgiou, R. Bourguiba, A. Mékinian, Benjamin Terrier , et al. · 2022

Pulmonary IgG4‐related disease with favourable response to rituximab: A case report Open

R. Müller, Mikaël Ebbo, Paul Habert, Julia Torrents, Jean Gaubert , et al. · 2022

Pulmonary involvement of IgG4‐associated disease is a rare condition with no codified treatment apart from steroid administration. We report here the case of a patient with pulmonary involvement of IgG4‐RD successfully managed with Rituxim…

Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study Open

S. Guillet, Valentine Loustau, Emmanuelle Boutin, Anissa Zarour, Thibault Comont , et al. · 2022

The risk of immune thrombocytopenia (ITP) worsening during pregnancy and neonatal ITP (NITP) have never been prospectively studied. We included 180 pregnant and 168 nonpregnant women with ITP in a prospective, multicenter, observational co…

Mikaël Ebbo YOU? Author Swipe