Mikayla Eppert
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View article: Coactivator condensation drives cardiovascular cell lineage specification
Coactivator condensation drives cardiovascular cell lineage specification Open
During development, cells make switch-like decisions to activate new gene programs specifying cell lineage. The mechanisms underlying these decisive choices remain unclear. Here, we show that the cardiovascular transcriptional coactivator …
View article: Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis
Continuous double-strand break induction and their differential processing sustain chiasma formation during Caenorhabditis elegans meiosis Open
Faithful chromosome segregation into gametes depends on Spo11-induced DNA double-strand breaks (DSBs). These yield single-stranded 3' tails upon resection to promote crossovers (COs). While early Mre11-dependent end resection is the predom…