Mike Barbeck
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View article: Comparative Evaluation of Biocompatibility Data from the Subcutaneous and the Calvaria Implantation Model of a Novel Bone Substitute Block
Comparative Evaluation of Biocompatibility Data from the Subcutaneous and the Calvaria Implantation Model of a Novel Bone Substitute Block Open
These results highlight the critical impact of implantation site on immune activation, vascularization, and biomaterial resorption, underlining the importance of model selection in preclinical biomaterial assessment.
View article: Editorial: Translational development of tailored implants via advanced processing and surface modifications for tissue regeneration
Editorial: Translational development of tailored implants via advanced processing and surface modifications for tissue regeneration Open
View article: <i>In Vitro, Ex Vivo</i> and <i>In Vivo</i> Characterization of Cytocompatibility and Biocompatibility of a Cross-linked Fish Collagen Wound Membrane
<i>In Vitro, Ex Vivo</i> and <i>In Vivo</i> Characterization of Cytocompatibility and Biocompatibility of a Cross-linked Fish Collagen Wound Membrane Open
The results of this study highlight the potential of fish collagen membranes as biocompatible wound healing materials. However, their rapid degradation presents a challenge that needs to be addressed through targeted modifications, such as…
View article: PLLA Coating of Lyophilized Human Bone Allograft for Long-term Release of Antibiotics
PLLA Coating of Lyophilized Human Bone Allograft for Long-term Release of Antibiotics Open
Based on these results, future optimization can focus on selecting more efficient release of antibiotics and increasing the encapsulated concentration to sustain antibiotic release over 4 months, thereby improving the bacteriostatic effect…
View article: Validation of the Chick Chorioallantoic Membrane (CAM) Model for Biocompatibility Analysis of Biomaterials in the Context of the 3R-cascade: A Pilot Study
Validation of the Chick Chorioallantoic Membrane (CAM) Model for Biocompatibility Analysis of Biomaterials in the Context of the 3R-cascade: A Pilot Study Open
We suggest that bioincompatible biomaterials can already be sorted out in the context of THE preclinical in vivo test phase. Such pre-testing before the required small animal tests might clearly contribute to the 3R-concept to reduc…
View article: Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applications
Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applications Open
In the field of biomedical implants, additively manufactured titanium alloys, particularly Ti-6Al-4V, hold significant potential due to their biocompatibility and mechanical properties. This study focuses on the characterization and modeli…
View article: The influence of different crosslinking agents onto the physical properties, integration behavior and immune response of collagen-based barrier membranes
The influence of different crosslinking agents onto the physical properties, integration behavior and immune response of collagen-based barrier membranes Open
This study investigates the mechanical properties as well as in vitro and in vivo cyto- and biocompatibility of collagen membranes cross-linked with glutaraldehyde (GA), proanthocyanidins (PC), hexamethylendiisocyanate (HMDI) and 1-Ethyl-3…
View article: Composite polymer/wax coatings as a corrosion barrier of bioresorbable magnesium coronary stents
Composite polymer/wax coatings as a corrosion barrier of bioresorbable magnesium coronary stents Open
View article: Biphasic bone substitutes coated with PLGA incorporating therapeutic ions Sr2+ and Mg2+: cytotoxicity cascade and in vivo response of immune and bone regeneration
Biphasic bone substitutes coated with PLGA incorporating therapeutic ions Sr2+ and Mg2+: cytotoxicity cascade and in vivo response of immune and bone regeneration Open
The incorporation of bioactive ions into biomaterials has gained significant attention as a strategy to enhance bone tissue regeneration on the molecular level. However, little knowledge exists about the effects of the addition of these io…
View article: Control of Cell Adhesion and Growth on Polysaccharide-Based Multilayer Coatings by Incorporation of Graphene Oxide
Control of Cell Adhesion and Growth on Polysaccharide-Based Multilayer Coatings by Incorporation of Graphene Oxide Open
Controlling cell adhesion, viability, and proliferation on solid surfaces is critical for the successful implantation and proper functioning of temporary and permanent medical devices. While, with temporary or removable implants as well as…
View article: Deciphering UVA/Riboflavin Collagen Crosslinking: A Pathway to Improve Biomedical Materials
Deciphering UVA/Riboflavin Collagen Crosslinking: A Pathway to Improve Biomedical Materials Open
Collagen crosslinking employing ultraviolet A rays and riboflavin (UVA/R) has emerged as a pivotal technique in clinical therapies, especially in ophthalmology since the 1990s. Despite its clinical adoption, the lack of clarity of the deta…
View article: <i>In Vitro</i>Cytocompatibility Analysis and Comparison of Different Hyaluronic Acid Fillers for Minimally Invasive Esthetics
<i>In Vitro</i>Cytocompatibility Analysis and Comparison of Different Hyaluronic Acid Fillers for Minimally Invasive Esthetics Open
All biodegradable fillers examined in this study were found to be sufficiently cytocompatible. Although the qualitative analysis of the test results showed differences between the fillers, no concrete correlation between test performance a…
View article: Analyses of the Cellular Interactions between the Ossification of Collagen-Based Barrier Membranes and the Underlying Bone Defects
Analyses of the Cellular Interactions between the Ossification of Collagen-Based Barrier Membranes and the Underlying Bone Defects Open
Barrier membranes are an essential tool in guided bone Regeneration (GBR), which have been widely presumed to have a bioactive effect that is beyond their occluding and space maintenance functionalities. A standardized calvaria implantatio…
View article: The Use of Collagen-Based Materials in Bone Tissue Engineering
The Use of Collagen-Based Materials in Bone Tissue Engineering Open
Synthetic bone substitute materials (BSMs) are becoming the general trend, replacing autologous grafting for bone tissue engineering (BTE) in orthopedic research and clinical practice. As the main component of bone matrix, collagen type I …
View article: Suitability of R. pulmo Jellyfish-Collagen-Coated Well Plates for Cytocompatibility Analyses of Biomaterials
Suitability of R. pulmo Jellyfish-Collagen-Coated Well Plates for Cytocompatibility Analyses of Biomaterials Open
Cytocompatibility analyses of new implant materials or biomaterials are not only prescribed by the Medical Device Regulation (MDR), as defined in the DIN ISO Norm 10993-5 and -12, but are also increasingly replacing animal testing. In this…
View article: Republication:<i>In Vitro</i>and<i>Ex Vivo</i>Analysis of Collagen Foams for Soft and Hard Tissue Regeneration
Republication:<i>In Vitro</i>and<i>Ex Vivo</i>Analysis of Collagen Foams for Soft and Hard Tissue Regeneration Open
Collagen sponges represent a promising material for hard and soft tissue regeneration. Future studies could focus on integrating and investigating different additives in the foams.
View article: Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes
Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes Open
Guided bone regeneration (GBR) has become a clinically standard modality for the treatment of localized jawbone defects. Barrier membranes play an important role in this process by preventing soft tissue invasion outgoing from the mucosa a…
View article: In Vivo Analysis of the Regeneration Capacity and Immune Response to Xenogeneic and Synthetic Bone Substitute Materials
In Vivo Analysis of the Regeneration Capacity and Immune Response to Xenogeneic and Synthetic Bone Substitute Materials Open
Although various studies have investigated differences in the tissue reaction pattern to synthetic and xenogeneic bone substitute materials (BSMs), a lack of knowledge exists regarding the classification of both materials based on the DIN …
View article: Encapsulated vaterite-calcite CaCO3 particles loaded with Mg2+ and Cu2+ ions with sustained release promoting osteogenesis and angiogenesis
Encapsulated vaterite-calcite CaCO3 particles loaded with Mg2+ and Cu2+ ions with sustained release promoting osteogenesis and angiogenesis Open
Bioactive cations, including calcium, copper and magnesium, have shown the potential to become the alternative to protein growth factor-based therapeutics for bone healing. Ion substitutions are less costly, more stable, and more effective…
View article: Lyophilized Human Bone Allograft as an Antibiotic Carrier: An In Vitro and In Vivo Study
Lyophilized Human Bone Allograft as an Antibiotic Carrier: An In Vitro and In Vivo Study Open
Background: Antibiotics delivered from implanted bone substitute materials (BSM) can potentially be used to prevent acute infections and biofilm formation, providing high concentrations of antibiotics at the surgical site without systemic …
View article: In Vivo Analysis of the Immune Response to Strontium- and Copper-doped Bioglasses
In Vivo Analysis of the Immune Response to Strontium- and Copper-doped Bioglasses Open
Bioglasses are highly adoptable bone substitute materials, which can be combined with so-called therapeutic ions. These ions have shown to influence underlying molecular processes of the bone regeneration cascade. Moreover, it is known tha…
View article: Comparative analysis of lateral maxillary sinus augmentation with a xenogeneic bone substitute material in combination with piezosurgical preparation and bony wall repositioning or rotary instrumentation and membrane coverage: a prospective randomized clinical and histological study
Comparative analysis of lateral maxillary sinus augmentation with a xenogeneic bone substitute material in combination with piezosurgical preparation and bony wall repositioning or rotary instrumentation and membrane coverage: a prospective randomized clinical and histological study Open
Objectives The present randomized controlled clinical study aimed to investigate if, in lateral maxillary sinus augmentation, the repositioned bony wall or the application of a collagen membrane results in more preferable new hard tissue f…
View article: In Vivo Biocompatibility Analysis of a Novel Barrier Membrane Based on Bovine Dermis-Derived Collagen for Guided Bone Regeneration (GBR)
In Vivo Biocompatibility Analysis of a Novel Barrier Membrane Based on Bovine Dermis-Derived Collagen for Guided Bone Regeneration (GBR) Open
Collagen-based barrier membranes are nowadays the prevalent option for Guided Bone Regeneration (GBR) procedures. Xenogeneic collagen is highly biocompatible as it shares a similar structure to native human collagen, which prevents it from…
View article: Editorial of the Special Issue: “Soft and Hard Tissue Regeneration”
Editorial of the Special Issue: “Soft and Hard Tissue Regeneration” Open
In general, only a total of four tissue classes are distinguished: the covering tissue (epithelial tissue), the connective and supporting tissue (connective tissue, fatty tissue, bone, and cartilage), the muscle tissue, and the nervous tis…
View article: In Vivo Biocompatibility Investigation of an Injectable Calcium Carbonate (Vaterite) as a Bone Substitute including Compositional Analysis via SEM-EDX Technology
In Vivo Biocompatibility Investigation of an Injectable Calcium Carbonate (Vaterite) as a Bone Substitute including Compositional Analysis via SEM-EDX Technology Open
Injectable bone substitutes (IBS) are increasingly being used in the fields of orthopedics and maxillofacial/oral surgery. The rheological properties of IBS allow for proper and less invasive filling of bony defects. Vaterite is the most u…
View article: Comparison of the Validity of Enzymatic and Immunohistochemical Detection of Tartrate-resistant Acid Phosphatase (TRAP) in the Context of Biocompatibility Analyses of Bone Substitutes
Comparison of the Validity of Enzymatic and Immunohistochemical Detection of Tartrate-resistant Acid Phosphatase (TRAP) in the Context of Biocompatibility Analyses of Bone Substitutes Open
The immunohistochemical detection of TRAP is more accurate for examination of the bioactivity and cellular degradability of BSM.
View article: <i>In Vivo</i>Analysis of the Immune Response to Strontium- and Copper-doped Bioglass
<i>In Vivo</i>Analysis of the Immune Response to Strontium- and Copper-doped Bioglass Open
Bioglass doping with copper and strontium did not significantly influence the foreign body response nor vascularization of the implantation bed in vivo. However, all the studied bioglass materials seemed to be biocompatible.
View article: <i>In Vitro</i>Analysis of the Cytocompatibility of a Novel Porcine Aortic Patch for Vascular Reconstruction
<i>In Vitro</i>Analysis of the Cytocompatibility of a Novel Porcine Aortic Patch for Vascular Reconstruction Open
The novel graft shows no structural damage and gets completely decellularized by the purification process. Superior cytocompatibility, compared with the bovine-derived vascular graft, was demonstrated.
View article: The Granule Size Mediates the In Vivo Foreign Body Response and the Integration Behavior of Bone Substitutes
The Granule Size Mediates the In Vivo Foreign Body Response and the Integration Behavior of Bone Substitutes Open
The physicochemical properties of synthetically produced bone substitute materials (BSM) have a major impact on biocompatibility. This affects bony tissue integration, osteoconduction, as well as the degradation pattern and the correlated …
View article: Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR)
Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR) Open
Background: Magnesium (Mg) is one of the most promising materials for human use in surgery due to material characteristics such as its elastic modulus as well as its resorbable and regenerative properties. In this study, HF-coated and unco…