Mike Friedrich
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View article: 3D In Vitro Glioma‐Neuron‐Astrocyte Biomimetic Composites Recapitulate Key Molecular Mechanisms Linked to Glioblastoma Multiforme Pathophysiology
3D In Vitro Glioma‐Neuron‐Astrocyte Biomimetic Composites Recapitulate Key Molecular Mechanisms Linked to Glioblastoma Multiforme Pathophysiology Open
Glioblastoma multiforme is the most devastating brain tumor without cure. Although in vitro and in vivo research on glioblastoma multiforme have demonstrated its complexity, including interactions with brain cells and the tumor microenviro…
View article: A vascularized breast cancer spheroid platform for the ranked evaluation of tumor microenvironment-targeted drugs by light sheet fluorescence microscopy
A vascularized breast cancer spheroid platform for the ranked evaluation of tumor microenvironment-targeted drugs by light sheet fluorescence microscopy Open
Targeting the supportive tumor microenvironment (TME) is an approach of high interest in cancer drug development. However, assessing TME-targeted drug candidates presents a unique set of challenges. We develop a comprehensive screening pla…
View article: A humanized breast cancer microorganoid platform for the ranked evaluation of tumor microenvironment-targeted drugs by light sheet fluorescence microscopy
A humanized breast cancer microorganoid platform for the ranked evaluation of tumor microenvironment-targeted drugs by light sheet fluorescence microscopy Open
Targeting the supportive tumor microenvironment (TME) is an approach of high interest in cancer drug development. However, assessing TME-targeted drug candidates presents a unique set of challenges: Adequate assays need to recreate the TME…
View article: Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism
Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism Open
Xiphophorus fish exhibit a clear phenotypic polymorphism in puberty onset and reproductive strategies of males. In X. nigrensis and X. multilineatus , puberty onset is genetically determined and linked to a melanocortin 4 receptor (Mc4r) p…
View article: Platelet‐derived lipids promote insulin secretion of pancreatic β cells
Platelet‐derived lipids promote insulin secretion of pancreatic β cells Open
Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism.…
View article: Image-based modeling of vascular organization to evaluate anti-angiogenic therapy
Image-based modeling of vascular organization to evaluate anti-angiogenic therapy Open
In tumor therapy anti-angiogenic approaches have the potential to increase the efficacy of a wide variety of subsequently or co-administered agents, possibly by improving or normalizing the defective tumor vasculature. Successful implement…
View article: Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism
Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism Open
Example dataset and scripts used in the analysis of PIE-based FRET-FLIM data of the Mc4r receptor.
View article: Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism
Dimerization of melanocortin 4 receptor controls puberty onset and body size polymorphism Open
Example dataset and scripts used in the analysis of PIE-based FRET-FLIM data of the Mc4r receptor.
View article: Imaged-based modeling of vascular organization to evaluate anti-angiogenic therapy
Imaged-based modeling of vascular organization to evaluate anti-angiogenic therapy Open
In tumor therapy anti-angiogenic approaches have the potential to increase the efficacy of a wide variety of subsequently or co-administered agents, possibly by improving or normalizing the defective tumor vasculature. Successful implement…
View article: Unraveling the hidden temporal range of fast β2-adrenergic receptor mobility by time-resolved fluorescence
Unraveling the hidden temporal range of fast β2-adrenergic receptor mobility by time-resolved fluorescence Open
View article: Dual-Color Fluorescence Cross-Correlation Spectroscopy to Study Protein-Protein Interaction and Protein Dynamics in Live Cells
Dual-Color Fluorescence Cross-Correlation Spectroscopy to Study Protein-Protein Interaction and Protein Dynamics in Live Cells Open
We present a protocol and workflow to perform live cell dual-color fluorescence cross-correlation spectroscopy (FCCS) combined with Förster Resonance Energy transfer (FRET) to study membrane receptor dynamics in live cells using modern flu…
View article: Dual-color Fluorescence Cross-Correlation Spectroscopy to study Protein-Protein Interaction and Protein Dynamics in Live Cells
Dual-color Fluorescence Cross-Correlation Spectroscopy to study Protein-Protein Interaction and Protein Dynamics in Live Cells Open
We present a protocol and workflow to perform live cell dual-color fluorescence crosscorrelation spectroscopy (FCCS) combined with Förster Resonance Energy transfer (FRET) to study membrane receptor dynamics in live cells using modern fluo…
View article: Thrombopoiesis is spatially regulated by the bone marrow vasculature
Thrombopoiesis is spatially regulated by the bone marrow vasculature Open
In mammals, megakaryocytes (MKs) in the bone marrow (BM) produce blood platelets, required for hemostasis and thrombosis. MKs originate from hematopoietic stem cells and are thought to migrate from an endosteal niche towards the vascular s…
View article: Image‐based modeling and scoring of Howell–Jolly Bodies in human erythrocytes
Image‐based modeling and scoring of Howell–Jolly Bodies in human erythrocytes Open
The spleen selectively removes cells with intracellular inclusions, for example, detached nuclear fragments in circulating erythrocytes, called Howell–Jolly Bodies (HJBs). With absent or deficient splenic function HJBs appear in the periph…
View article: Myocardial aging as a T-cell–mediated phenomenon
Myocardial aging as a T-cell–mediated phenomenon Open
Significance Aging is a risk factor for heart diseases, and it is also known to impact on several immunological processes. Nevertheless, most studies addressing the cardio-immune cross-talk have focused on juvenile rather than senescent an…
View article: Beyond an ‘On-Off’ Activation Model of G-Protein-Coupled Receptors
Beyond an ‘On-Off’ Activation Model of G-Protein-Coupled Receptors Open
View article: Axial resolution beyond the diffraction limit of a sheet illumination microscope with stimulated emission depletion
Axial resolution beyond the diffraction limit of a sheet illumination microscope with stimulated emission depletion Open
Planar illumination imaging allows for illumination of the focal plane orthogonal to the imaging axis in various light forms and is advantageous for high optical sectioning, high imaging speed, low light exposure, and inherently deeper ima…
View article: Oncostatic effects of fluoxetine in experimental colon cancer models
Oncostatic effects of fluoxetine in experimental colon cancer models Open