Mike Lonergan
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View article: A fire deficit persists across diverse North American forests despite recent increases in area burned
A fire deficit persists across diverse North American forests despite recent increases in area burned Open
Rapid increases in wildfire area burned across North American forests pose novel challenges for managers and society. Increasing area burned raises questions about whether, and to what degree, contemporary fire regimes (1984-2022) are stil…
View article: Spatiotemporal Synchrony of Climate and Fire Occurrence Across North American Forests (1750–1880)
Spatiotemporal Synchrony of Climate and Fire Occurrence Across North American Forests (1750–1880) Open
Aim Increasing aridity has driven widespread synchronous fire occurrence in recent decades across North America. The lack of historical (pre‐1880) fire records limits our ability to understand long‐term continental fire‐climate dynamics. T…
View article: A cuckoo COVID coincidence?
A cuckoo COVID coincidence? Open
There are limitations to inferring causality from observational data, but lockdowns have almost certainly saved lives worldwide https://bit.ly/2YWAhhl
View article: Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD
Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD Open
View article: Data presented by the UK government as lockdown was eased shows the transmission of COVID-19 had already increased
Data presented by the UK government as lockdown was eased shows the transmission of COVID-19 had already increased Open
Background Coronavirus disease 2019 (COVID-19) is an international emergency that has been addressed in many countries by changes in and restrictions on behaviour. These are often collectively labelled social distancing and lockdown. On th…
View article: Blood Neutrophil Counts are Associated with Exacerbation Frequency and Mortality in COPD
Blood Neutrophil Counts are Associated with Exacerbation Frequency and Mortality in COPD Open
Background: Identifying patients with COPD at increased risk of poor outcomes is challenging due to disease heterogeneity. Potential biomarkers need to be readily available in real-life clinical practice. Blood eosinophil counts are widely…
View article: Even one metre seems generous. A reanalysis of data in: Chu et al. (2020) Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19.
Even one metre seems generous. A reanalysis of data in: Chu et al. (2020) Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19. Open
Re-examination of the large dataset collected and meta-analysed by Dr Chu and his colleagues contradicts their conclusions about the effects of separation distance on infection risk. Their conclusion was based on misunderstandings of the d…
View article: Estimates of the ongoing need for social distancing and control measures post-“lockdown” from trajectories of COVID-19 cases and mortality
Estimates of the ongoing need for social distancing and control measures post-“lockdown” from trajectories of COVID-19 cases and mortality Open
By 21 May 2020, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) had caused more than 5 million cases of coronavirus 2019 (COVID-19) across more than 200 countries. Most countries with significant outbreaks have introduced soci…
View article: Clinical endotypes of exacerbation are associated with differences in microbial composition and diversity in COPD
Clinical endotypes of exacerbation are associated with differences in microbial composition and diversity in COPD Open
COPD exacerbations are associated with worsening symptoms including cough, shortness of breath, sputum production and airflow obstruction. Increased numbers of exacerbations are associated with morbidity and mortality [1]. Exacerbations ar…
View article: Estimates of the ongoing need for social distancing and control measures post-“lockdown” from trajectories of COVID-19 cases and mortality
Estimates of the ongoing need for social distancing and control measures post-“lockdown” from trajectories of COVID-19 cases and mortality Open
By 29 th April 2020, COVID-19 had caused more than 3 million cases across more than 200 countries. And most countries with significant outbreaks had introduced social distancing or “lockdown” measures to reduce viral transmission. So the k…
View article: The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease
The sputum microbiome, airway inflammation, and mortality in chronic obstructive pulmonary disease Open
View article: Inhaled aztreonam improves symptoms of cough and sputum production in patients with bronchiectasis: a<i>post hoc</i>analysis of the AIR-BX studies
Inhaled aztreonam improves symptoms of cough and sputum production in patients with bronchiectasis: a<i>post hoc</i>analysis of the AIR-BX studies Open
Introduction Inhaled antibiotics may improve symptom scores, but it is not known which specific symptoms improve with therapy. Item-level analysis of questionnaire data may allow us to identify which specific symptoms respond best to treat…
View article: Blood Neutrophil Counts are Associated with Exacerbation Frequency and Mortality in COPD
Blood Neutrophil Counts are Associated with Exacerbation Frequency and Mortality in COPD Open
Background Identifying patients with COPD at increased risk of poor outcomes is challenging due to disease heterogeneity. Potential biomarkers need to be readily available in real-life clinical practice. Blood eosinophil counts are widely …
View article: Relationship between Symptoms, Exacerbations, and Treatment Response in Bronchiectasis
Relationship between Symptoms, Exacerbations, and Treatment Response in Bronchiectasis Open
Rationale: Bronchiectasis guidelines regard treatment to prevent exacerbation and treatment of daily symptoms as separate objectives.Objectives: We hypothesized that patients with greater symptoms would be at higher risk of e…
View article: Neutrophil Extracellular Traps are Increased in Severe Bronchiectasis and Reduced by Long-Term Azithromycin Treatment
Neutrophil Extracellular Traps are Increased in Severe Bronchiectasis and Reduced by Long-Term Azithromycin Treatment Open
View article: Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis
Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis Open
View article: Pulmonary rehabilitation after exacerbation of bronchiectasis: a pilot randomized controlled trial
Pulmonary rehabilitation after exacerbation of bronchiectasis: a pilot randomized controlled trial Open
NCT02179983, registered on Clinicaltrials.gov 29th June 2014.
View article: The Sputum Microbiome Is Associated with Lung Inflammation, Exacerbations and Mortality in Patients with Bronchiectasis
The Sputum Microbiome Is Associated with Lung Inflammation, Exacerbations and Mortality in Patients with Bronchiectasis Open
View article: Harbor seal pup dispersal and individual morphology, hematology, and contaminant factors affecting survival
Harbor seal pup dispersal and individual morphology, hematology, and contaminant factors affecting survival Open
Understanding the factors affecting individual harbor seal ( Phoca vitulina ) survival is essential for determining population level health risks. We estimated postweaning dispersal, and modeled the effects of morphology, hematology, and b…
View article: Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data
Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data Open
OBJECTIVE The choice of therapy for type 2 diabetes after metformin is guided by overall estimates of glycemic response and side effects seen in large cohorts. A stratified approach to therapy would aim to improve on this by identifying su…
View article: Pathogenicity and Penetrance of Germline SDHA Variants in Pheochromocytoma and Paraganglioma (PPGL)
Pathogenicity and Penetrance of Germline SDHA Variants in Pheochromocytoma and Paraganglioma (PPGL) Open
Germline SDHA mutations are reported in a minority of pheochromocytoma/paraganglioma (PPGL) cases but are associated with an increased risk of malignancy, leading some to advocate cascade genetic testing and surveillance screening o…
View article: Pharmacokinetics of metformin in patients with gastrointestinal intolerance
Pharmacokinetics of metformin in patients with gastrointestinal intolerance Open
Aims To assess potential causes of metformin intolerance, including altered metformin uptake from the intestine, increased anaerobic glucose utilization and subsequent lactate production, altered serotonin uptake, and altered bile acid poo…
View article: Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study
Costs and Treatment Pathways for Type 2 Diabetes in the UK: A Mastermind Cohort Study Open
Medication therapy has undergone substantial changes during the period covered in this study. For example, therapy is initiated earlier and is less expensive than in the past. The data provided in this study will prove useful for future mo…
View article: Harbour seals (<scp><i>Phoca vitulina</i></scp>) around an operational tidal turbine in Strangford Narrows: No barrier effect but small changes in transit behaviour
Harbour seals (<span><i>Phoca vitulina</i></span>) around an operational tidal turbine in Strangford Narrows: No barrier effect but small changes in transit behaviour Open
Data were obtained from 32 electronic tags that were glued to the fur of harbour seals ( Phoca vitulina ) in and around Strangford Lough, Northern Ireland, during the environmental monitoring of the SeaGen tidal turbine. This study provide…
View article: Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: <scp>A GoDarts</scp> study
Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: <span>A GoDarts</span> study Open
Aims Metformin is renally excreted and has been associated with the development of lactic acidosis. Although current advice is to omit metformin during illnesses that may increase the risk of acute kidney injury ( AKI ), the evidence suppo…
View article: Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?
Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c? Open
Adjustment for the baseline HbA1c measurement is a simple and effective way to reduce bias in studies of predictors of response to glucose lowering therapy.
View article: Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database
Adherence to Oral Glucose-Lowering Therapies and Associations With 1-Year HbA1c: A Retrospective Cohort Analysis in a Large Primary Care Database Open
OBJECTIVE The impact of taking oral glucose-lowering medicines intermittently, rather than as recommended, is unclear. We conducted a retrospective cohort study using community-acquired U.K. clinical data (Clinical Practice Research Databa…
View article: Conspecific recognition and aggression reduction to familiars in newly weaned, socially plastic mammals
Conspecific recognition and aggression reduction to familiars in newly weaned, socially plastic mammals Open
Recognising conspecifics and behaving appropriately towards them is a crucial ability for many species. Grey seals (Halichoerus grypus) show varying capabilities in this regard: mother-pup recognition has been demonstrated in some g…