Mike Paulden
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View article: Aligning Indigenous and Western Concepts of Health Resource Decision Making in a Western Canadian First Nations Context
Aligning Indigenous and Western Concepts of Health Resource Decision Making in a Western Canadian First Nations Context Open
Background Western health economic evaluation tools often fail to reflect the relational, collective, and holistic perspectives that underpin Indigenous concepts of health. These limitations pose challenges when applying Western measures i…
View article: Designing an integrated program for intimate partner violence screening and referral at a hospital trauma service in Alberta, Canada
Designing an integrated program for intimate partner violence screening and referral at a hospital trauma service in Alberta, Canada Open
Background: Intimate partner violence (IPV) is the primary cause of serious injury and the second leading cause of death among women of reproductive age in Canada. Alberta has one of the highest rates of IPV in Canada. Health systems play …
View article: The opportunity cost of funding new medicines: an attempt to measure the invisible
The opportunity cost of funding new medicines: an attempt to measure the invisible Open
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View article: A systematic review of health economic evaluation quality assessment instruments for medical devices
A systematic review of health economic evaluation quality assessment instruments for medical devices Open
Objectives Health economic evaluations are important for healthcare resource allocation. Reviews of health economic evaluations for medical devices have highlighted concerns about the quality of these studies. The complexity of medical dev…
View article: Do beta-amyloid-targeted interventions improve cognition, physical functioning, and overt behaviour of Alzheimer’s Disease (AD) patients: Protocol for meta-analysis of Phase 3 clinical trials both completed and terminated
Do beta-amyloid-targeted interventions improve cognition, physical functioning, and overt behaviour of Alzheimer’s Disease (AD) patients: Protocol for meta-analysis of Phase 3 clinical trials both completed and terminated Open
Accumulation of amyloid-beta (Aβ) in the brain has been explored as a primary cause of Alzheimer’s Disease (AD). Better known as the amyloid hypothesis, it has been the main target of researchers vying to bring their therapeutic interventi…
View article: Optimization of an adult immunization program in Canada
Optimization of an adult immunization program in Canada Open
Background Provincial decisions to fund a new immunization program are generally made on a case-by-case basis, without systematic consideration of how the new immunization program may fit within the larger provincial immunization portfolio…
View article: Logical Inconsistencies in the Health Years in Total and Equal Value of Life-Years Gained
Logical Inconsistencies in the Health Years in Total and Equal Value of Life-Years Gained Open
The HYT and evLYG approaches can result in logically inconsistent decisions. We recommend that decision makers avoid these approaches and that the logical consistency of any approaches proposed in future be thoroughly explored before consi…
View article: OP47 The Risk-Based Price: Incorporating Uncertainty And Risk Attitudes In Health Technology Pricing
OP47 The Risk-Based Price: Incorporating Uncertainty And Risk Attitudes In Health Technology Pricing Open
Introduction Decision makers often use value-based decision rules to determine whether technologies offer good value for money and should therefore be adopted, comparing cost-effectiveness analysis results with a threshold value. This assu…
View article: We need to talk about values: a proposed framework for the articulation of normative reasoning in health technology assessment
We need to talk about values: a proposed framework for the articulation of normative reasoning in health technology assessment Open
It is acknowledged that health technology assessment (HTA) is an inherently value-based activity that makes use of normative reasoning alongside empirical evidence. But the language used to conceptualise and articulate HTA's normative aspe…
View article: Challenges of calculating cost-effectiveness thresholds
Challenges of calculating cost-effectiveness thresholds Open
Contains fulltext : 296650.pdf (Publisher’s version ) (Open Access)
View article: Health Economic Evaluation Methodological Quality Assessment Tools: A protocol for a systematic review
Health Economic Evaluation Methodological Quality Assessment Tools: A protocol for a systematic review Open
eview question / Objective The aim of this systematic review is to find any existing methodological quality assessment checklists and tools for health economic evaluations. R a t i o n a l eT h e d e v e l o p m e n t o f a n e w methodolo…
View article: Prediction of odds for emergency cesarean section: A secondary analysis of the CHILD term birth cohort study
Prediction of odds for emergency cesarean section: A secondary analysis of the CHILD term birth cohort study Open
Introduction Previously developed cesarean section (CS) and emergency CS prediction tools use antenatal and intrapartum risk factors. We aimed to develop a predictive model for the risk of emergency CS before the onset of labour utilizing …
View article: Evaluating the Individual Healthcare Costs and Burden of Disease Associated with RSV Across Age Groups
Evaluating the Individual Healthcare Costs and Burden of Disease Associated with RSV Across Age Groups Open
RSV is a common and expensive infection at the extremes of life, and the development of immunization programs targeting older and younger ages may be important for the reduction of RSV burden and cost.
View article: Small differences in EQ-5D-5L health utility scores were interpreted differently between and within respondents
Small differences in EQ-5D-5L health utility scores were interpreted differently between and within respondents Open
A HUS needs to be large enough to reflect individuals' stated health preferences, which may lend support to the application of a minimally important difference for decision-making.
View article: Implementing Interventions with Varying Marginal Cost-Effectiveness: An Application in Precision Medicine
Implementing Interventions with Varying Marginal Cost-Effectiveness: An Application in Precision Medicine Open
Purpose. A range of barriers may constrain the effective implementation of strategies to deliver precision medicine. If the marginal costs and consequences of precision medicine vary at different levels of implementation, then such variati…
View article: The health and financial impacts of a sugary drink tax across different income groups in Canada
The health and financial impacts of a sugary drink tax across different income groups in Canada Open
Low-income Canadians would gain the most health benefit from a sugary drinks tax. However, the lowest income quintile would also pay the largest proportion of income in tax. A tax on sugary drinks is therefore financially regressive but fo…
View article: Quality of reporting of economic evaluations in rehabilitation research: a systematic review
Quality of reporting of economic evaluations in rehabilitation research: a systematic review Open
The quality of reporting of health economic evaluations for rehabilitation services has been questioned, limiting the ability to provide accurate recommendations for health decisions. To document current overall reporting quality of the pu…
View article: Accounting for timing when assessing health-related policies
Accounting for timing when assessing health-related policies Open
The primary focus of this paper is to offer guidance on the analysis of time streams of effects that a project may have so that they can be discounted appropriately. This requires a framework that identifies the common parameters that need…
View article: Non‐pharmacological management of persistent headaches associated with neck pain: A clinical practice guideline from the Ontario protocol for traffic injury management (OPTIMa) collaboration
Non‐pharmacological management of persistent headaches associated with neck pain: A clinical practice guideline from the Ontario protocol for traffic injury management (OPTIMa) collaboration Open
Objectives To develop an evidence‐based guideline for the non‐pharmacological management of persistent headaches associated with neck pain (i.e., tension‐type or cervicogenic). Methods This guideline is based on systematic reviews of high‐…
View article: Accounting for Timing when Assessing Health-Related Policies
Accounting for Timing when Assessing Health-Related Policies Open
The primary focus of this paper is to offer guidance on the analysis of time streams of effects that a project may have so that they can be discounted appropriately. This requires a framework that identifies the common parameters that need…