Michael J. Rogers
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View article: NLRP3 is a thermosensor that is negatively regulated by high temperature
NLRP3 is a thermosensor that is negatively regulated by high temperature Open
Inflammation is an essential response to infection and injury, but unregulated inflammation is damaging and must be limited by negative feedback signalling. Inflammasome signalling drives local inflammation and systemic responses like feve…
View article: HMGCS1 Deficiency Is a Novel Immunometabolic Autoinflammatory Disease with Progressive Myositis
HMGCS1 Deficiency Is a Novel Immunometabolic Autoinflammatory Disease with Progressive Myositis Open
The mevalonate kinase (MVK) pathway is an essential metabolic pathway for sterol and isoprenoid synthesis. Non-sterol isoprenoids have critical biological functions in the post-translational modifications of numerous signaling molecules vi…
View article: A semi‐automated <scp>ASC</scp> speck assay to evaluate pyrin inflammasome activation
A semi‐automated <span>ASC</span> speck assay to evaluate pyrin inflammasome activation Open
Objective To develop a rapid functional assay to validate variants of uncertain significance (VUS) in the MEFV gene. Methods Overactivity of the pyrin inflammasome pathway and ASC speck oligomerisation in response to stimulation with low c…
View article: Home-Based Cardiac Rehabilitation Among Attendees From a Large Health Care System During the Covid-19 Pandemic
Home-Based Cardiac Rehabilitation Among Attendees From a Large Health Care System During the Covid-19 Pandemic Open
Patients participating in HBCR during the COVID-19 pandemic demonstrated similar participation rates compared to CBCR. HBCR appears to be similarly effective at improving several intermediate outcomes compared to CBCR. HBCR may be a suitab…
View article: Supplementary Movie 5 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie 5 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
3D reconstruction of 4T1 mammary tumour 24 hours after injection of bisphosphonate.
View article: Supplementary Movie 3 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie 3 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Real-time intravital two-photon microscopy showing pinocytosis of bisphosphonate by a single tumour-associated macrophage.
View article: Supplementary Movie Legends from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie Legends from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Supplementary Movie Legends
View article: Supplementary Methods from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Methods from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Supplementary Methods
View article: Supplementary Movie 3 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie 3 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Real-time intravital two-photon microscopy showing pinocytosis of bisphosphonate by a single tumour-associated macrophage.
View article: Supplementary Movie Legends from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie Legends from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Supplementary Movie Legends
View article: Supplementary Movie 2 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie 2 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Real-time intravital two-photon microscopy showing distribution of bisphosphonate in normal breast tissue.
View article: Supplementary Movie 4 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie 4 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Real-time intravital two-photon microscopy showing phagocytosis of a large, granular clump of bisphosphonate by a single tumour-associated macrophage.
View article: Supplementary Figures S1 - S3 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Figures S1 - S3 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Supplementary Figure S1. Fluorescently-labelled bisphosphonate is present in the macrophage-rich region of 4T1 mammary tumours in vivo. Supplementary Figure S2. N-BP colocalises with microcalcifications, detected by calcein labelling in 4T…
View article: Supplementary Movie 1 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie 1 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Real-time intravital two-photon microscopy showing distribution of bisphosphonate in 4T1 breast tumour.
View article: Supplementary Movie 4 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie 4 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Real-time intravital two-photon microscopy showing phagocytosis of a large, granular clump of bisphosphonate by a single tumour-associated macrophage.
View article: Data from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Data from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton. However, because bisphosphonates bind rapidly to bone mineral, the exact mechan…
View article: Supplementary Movie 2 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie 2 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Real-time intravital two-photon microscopy showing distribution of bisphosphonate in normal breast tissue.
View article: Data from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Data from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Recent clinical trials have shown that bisphosphonate drugs improve breast cancer patient survival independent of their antiresorptive effects on the skeleton. However, because bisphosphonates bind rapidly to bone mineral, the exact mechan…
View article: Supplementary Methods from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Methods from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Supplementary Methods
View article: Supplementary Figures S1 - S3 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Figures S1 - S3 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Supplementary Figure S1. Fluorescently-labelled bisphosphonate is present in the macrophage-rich region of 4T1 mammary tumours in vivo. Supplementary Figure S2. N-BP colocalises with microcalcifications, detected by calcein labelling in 4T…
View article: Supplementary Movie 5 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie 5 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
3D reconstruction of 4T1 mammary tumour 24 hours after injection of bisphosphonate.
View article: Supplementary Movie 1 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer
Supplementary Movie 1 from Real-Time Intravital Imaging Establishes Tumor-Associated Macrophages as the Extraskeletal Target of Bisphosphonate Action in Cancer Open
Real-time intravital two-photon microscopy showing distribution of bisphosphonate in 4T1 breast tumour.
View article: Supplementary Figure 1 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i>
Supplementary Figure 1 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i> Open
Supplementary Figure 1 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition In vivo
View article: Supplementary Figure Legends 1-3 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i>
Supplementary Figure Legends 1-3 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i> Open
Supplementary Figure Legends 1-3 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition In vivo
View article: Data from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i>
Data from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i> Open
Bisphosphonates bind avidly to bone mineral and are potent inhibitors of osteoclast-mediated bone destruction. They also exhibit antitumor activity in vitro. Here, we used a mouse model of human breast cancer bone metastasis to examine the…
View article: Supplementary Figure Legends 1-3 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i>
Supplementary Figure Legends 1-3 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i> Open
Supplementary Figure Legends 1-3 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition In vivo
View article: Supplementary Table 1 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i>
Supplementary Table 1 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i> Open
Supplementary Table 1 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition In vivo
View article: Supplementary Figure 1 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i>
Supplementary Figure 1 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition <i>In vivo</i> Open
Supplementary Figure 1 from Lowering Bone Mineral Affinity of Bisphosphonates as a Therapeutic Strategy to Optimize Skeletal Tumor Growth Inhibition In vivo