Min Yang
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View article: A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway
A window trial in metastatic pancreatic ductal adenocarcinoma reveals resistance mechanisms to targeting the KRAS-MEK pathway Open
Summary Copy number alterations of KRAS, mutated in over 90% of pancreatic ductal adenocarcinomas (PDAC), and MYC occur in 30-40% of PDAC. Here we demonstrate that KRAS and MYC are frequently co-gained and accompanied with worse prognosis …
View article: Xeligekimab, an Interleukin-17A Antagonist for Active Radiographic Axial Spondyloarthritis in Chinese Patients: 16- and 48-Week Results from a Phase III, Randomized, Double-Blind, Placebo-Controlled Study
Xeligekimab, an Interleukin-17A Antagonist for Active Radiographic Axial Spondyloarthritis in Chinese Patients: 16- and 48-Week Results from a Phase III, Randomized, Double-Blind, Placebo-Controlled Study Open
ClinicalTrials.gov identifier: NCT05881785 (Date: 21 May 2023).
View article: Applying Genetic Risk Score to Improve Risk Assessment of New‐Onset Lupus Nephritis in Systemic Lupus Erythematosus: A Large‐Scale Prospective Cohort Study
Applying Genetic Risk Score to Improve Risk Assessment of New‐Onset Lupus Nephritis in Systemic Lupus Erythematosus: A Large‐Scale Prospective Cohort Study Open
Lupus nephritis (LN) is one of the most severe manifestation of systemic lupus erythematosus (SLE). However, reliable tools for predicting LN risk remain limited. In this multicenter prospective cohort study, we developed, validated, and r…
View article: Case Report: 3 cases of abdominal lesions with lower limb lymphedema—rare mutations in complex lymphatic anomalies
Case Report: 3 cases of abdominal lesions with lower limb lymphedema—rare mutations in complex lymphatic anomalies Open
Complex lymphatic anomalies (CLAs) are rare vascular anomalies characterized by abnormal proliferation of lymphatic and blood vessels, often resulting in multisystem involvement with heterogeneous clinical manifestations. We present 3 pati…
View article: [Application of active glucose monitoring in the perioperative period of gastrointestinal endoscopy in children with glycogen storage disease type Ⅰb].
[Application of active glucose monitoring in the perioperative period of gastrointestinal endoscopy in children with glycogen storage disease type Ⅰb]. Open
Active glucose monitoring during the perioperative period of gastrointestinal endoscopy can help to achieve early detection of hypoglycemic states in children with GSD-Ⅰb, prevent hypoglycemic episodes, and enhance precise diagnosis and tr…
[Efficacy and safety of empagliflozin in the treatment of glycogen storage disease-associated inflammatory bowel disease]. Open
Empagliflozin therapy can increase neutrophil counts, reduce the incidence of infections and oral ulcers, alleviate diarrhea and abdominal pain, improve appetite, and ameliorate platelet count, lactate, and uric acid levels in patients wit…
View article: Comparisons of clinical features between paediatric and adult patients with surgically resected abdominal lymphatic malformations: An observational study of a large cohort
Comparisons of clinical features between paediatric and adult patients with surgically resected abdominal lymphatic malformations: An observational study of a large cohort Open
Introduction: Abdominal lymphatic malformations (ALMs) are a rare subgroup of lymphatic anomalies that may manifest differently between paediatric and adult patients. We aimed to systematically compare the clinical features of ALMs in term…
<i>Circ_0088200</i> acts as a sponge for miR-127-5p to promote the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes Open
Background Circular RNAs (circRNAs) play a crucial role in the development of various diseases. However, few studies have investigated the role of circRNAs in rheumatoid arthritis (RA). Herein, we aimed to identified the novel circRNAs inv…
Diagnosis of adult midgut malrotation in CT: sign of absent retromesenteric duodenum reliable Open
Objectives To compare the incidence of absent retromesenteric duodenum with other radiological signs and to assess its diagnostic significance for midgut malrotation in adults. Methods This IRB-approved retrospective single-center study in…
View article: Belimumab safety in adult and paediatric Chinese patients with systemic lupus erythematosus: A Phase 4, multicentre, observational study
Belimumab safety in adult and paediatric Chinese patients with systemic lupus erythematosus: A Phase 4, multicentre, observational study Open
Objective Although belimumab has been widely used in patients with systemic lupus erythematosus (SLE) globally, real-world safety data among Chinese patients are limited, particularly for children. This study assessed the safety and tolera…
View article: Predicting the risk of cardiovascular and cerebrovascular event in systemic lupus erythematosus: a Chinese SLE treatment and research group study XXVI
Predicting the risk of cardiovascular and cerebrovascular event in systemic lupus erythematosus: a Chinese SLE treatment and research group study XXVI Open
Objective Patients with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular and cerebrovascular events (CCEs). Furthermore, CCE was a significant factor contributing to mortality in patients with SLE. However, no cl…
View article: Empagliflozin in children with glycogen storage disease-associated inflammatory bowel disease: a prospective, single-arm, open-label clinical trial
Empagliflozin in children with glycogen storage disease-associated inflammatory bowel disease: a prospective, single-arm, open-label clinical trial Open
Glycogen storage disease type Ib (GSD-Ib) is a rare inborn error of glycogen metabolism caused by mutations in SLC37A4. Patients with GSD-Ib are at high risk of developing inflammatory bowel disease (IBD). We evaluated the efficacy of empa…
View article: GZMA Suppressed GPX4-mediated Ferroptosis to Improve Intestinal Mucosal Barrier Function in Inflammatory Bowel Disease
GZMA Suppressed GPX4-mediated Ferroptosis to Improve Intestinal Mucosal Barrier Function in Inflammatory Bowel Disease Open
Background Intestinal epithelial cells (IECs) is a critical component in maintaining intestinal homeostasis. Our previous study demonstrated a decreased population of colonic CD8+CD39+ T cells in pediatric-onset colitis and inflammatory bo…
Antiphospholipid antibodies as potential predictors of disease severity and poor prognosis in systemic lupus erythematosus-associated thrombocytopenia: results from a real-world CSTAR cohort study Open
Background To investigate the role of antiphospholipid antibodies (aPLs) in the disease severity and prognosis of SLE-related thrombocytopenia (SLE-TP). Methods This multicenter prospective study was conducted based on data from the CSTAR …
RETRACTED: Circ_0088200 promotes the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes through the miR-127-5p/MMP1 axis Open
The authors have requested that this preprint be removed from Research Square.
View article: Antiphospholipid Antibodies as Potential Predictors of Disease Severity and Poor Prognosis in Systemic Lupus Erythematosus-Associated Thrombocytopenia: Results from a Real-World CSTAR Cohort Study
Antiphospholipid Antibodies as Potential Predictors of Disease Severity and Poor Prognosis in Systemic Lupus Erythematosus-Associated Thrombocytopenia: Results from a Real-World CSTAR Cohort Study Open
Background : To investigate the role of antiphospholipid antibodies (aPLs) in the disease severity and prognosis of SLE-related thrombocytopenia. Methods: This multicenter prospective study was conducted based on data from the CSTAR regist…
View article: Development and external validation of a prediction model for venous thromboembolism in systemic lupus erythematosus
Development and external validation of a prediction model for venous thromboembolism in systemic lupus erythematosus Open
Objective Patients with systemic lupus erythematosus (SLE) have an increased risk of venous thromboembolism (VTE). We conducted this study to develop a risk score algorithm for VTE in patients with SLE that provides individualised risk est…
Intermittent fever and cough in a 56-year-old patient: Relapsing polychondritis and extranodal NK/T-cell lymphoma Open
Relapsing polychondritis (RP) is a rare autoimmune disease in which recurrent and progressive chondritis occurs throughout the body. We report a case of a 56-year-old female subject presented as intermittent fever and cough, who was found …
Sex differences in systemic lupus erythematosus (SLE): an inception cohort of the Chinese SLE Treatment and Research Group (CSTAR) registry XVII Open
Background: The onset and clinical presentation of systemic lupus erythematosus (SLE) are sex-related. Few studies have investigated the distinctions in clinical characteristics and treatment preferences in male and female SLE patients in …
View article: Chinese SLE Treatment and Research Group Registry (CSTAR) XIV: the subjective well-being of patients with systemic lupus erythematosus
Chinese SLE Treatment and Research Group Registry (CSTAR) XIV: the subjective well-being of patients with systemic lupus erythematosus Open
Background Systemic lupus erythematosus (SLE) can significantly influence patients’ quality of life and subjective well-being (SWB), but the relationships between clinical characteristics, SWB, and related psychological factors have been l…