Mikhail Maydin
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View article: Effect of inactivating heterozygous mutations in DNA repair genes on experimental lung carcinogenesis in mice
Effect of inactivating heterozygous mutations in DNA repair genes on experimental lung carcinogenesis in mice Open
Background. Inactivating mutations in Chek2 and Gprc5a genes are known to be associated with cancer development. Experimental carcinogenesis studies in genetically modified mice generate new data on their influence on pathology development…
View article: DEVELOPMENT AND CHARACTERISATION OF 3D SOLID TUMOUR CELL MODELS FOR INDIVIDUALIZED CANCER TREATMENT
DEVELOPMENT AND CHARACTERISATION OF 3D SOLID TUMOUR CELL MODELS FOR INDIVIDUALIZED CANCER TREATMENT Open
Background . To solve the problems of personalized medicine in oncology, preclinical studies based on the use of three-dimensional cellular models of tumors in vitro, including spheroids / tumoroids, are of great importance. They are an in…
View article: The effect of constant light and melatonin on urethane-induced lung carcinogenesis in mice and expression of clock genes and proteins
The effect of constant light and melatonin on urethane-induced lung carcinogenesis in mice and expression of clock genes and proteins Open
Introduction. Circadian rhythms are an adaptational mechanism to day-night cycle. At the cellular level rhythms are supported by oscillations of transcription of Bmal1, 2, Clock and Npas2, Per1-3, Cry1, 2 clock genes; in the organism rhyth…
View article: REVIEW OF RESEARCH ON THE RELATIONSHIP BETWEEN CIRCADIAN RHYTHMS AND CARCINOGENESIS USING ANIMAL MODELS
REVIEW OF RESEARCH ON THE RELATIONSHIP BETWEEN CIRCADIAN RHYTHMS AND CARCINOGENESIS USING ANIMAL MODELS Open
Purpose of the study: to review in vivo studies on the relationship and role of various molecular genetic components of the circadian rhythm system in the initiation and development of malignant neoplasms. in contrast to clinical and epide…
View article: Efficacy and Safety of Systemic and Locoregional Cisplatin Chronotherapy in Rats with Ovarian Carcinoma
Efficacy and Safety of Systemic and Locoregional Cisplatin Chronotherapy in Rats with Ovarian Carcinoma Open
In a rat model, ovarian tumor growth disrupted daily variations in intestinal epithelium proliferation and caused genotoxic stress in tumor-free tissues. HIPEC with cisplatin at ZT0 had a better efficacy/toxicity profile than HIPEC with ci…
View article: METHODOLOGICAL ASPECTS OF PHOTODYNAMIC THERAPY OF EHRLICH SOLID CARCINOMA IN BALB/C MOUSE STRAIN WITH VARIOUS TUMOR LOCALIZATION
METHODOLOGICAL ASPECTS OF PHOTODYNAMIC THERAPY OF EHRLICH SOLID CARCINOMA IN BALB/C MOUSE STRAIN WITH VARIOUS TUMOR LOCALIZATION Open
Background . Photodynamic Therapy is one of the treatment methods used in modern oncology. Evaluation of the efficacy in vivo of photosensitizers on tumor models is generally accepted, but the photodynamic therapy technique in mice is not …
View article: Modeling of Chemoperfusion vs. Intravenous Administration of Cisplatin in Wistar Rats: Adsorption and Tissue Distribution
Modeling of Chemoperfusion vs. Intravenous Administration of Cisplatin in Wistar Rats: Adsorption and Tissue Distribution Open
Hyperthermic intraperitoneal chemoperfusion (HIPEC) is an established form of locoregional chemotherapy of peritoneum tumors. However, its efficacy and safety status remain a controversy, partially, due to scarce data on pharmacokinetics a…
View article: DISRUPTED DAILY OSCILLATIONS OF CLOCK GENES EXPRESSION AND CLOCK PROTEINS CONTENT IN TUMORS AND DISTANT TISSUES IN HER2/NEU TRANSGENIC MICE
DISRUPTED DAILY OSCILLATIONS OF CLOCK GENES EXPRESSION AND CLOCK PROTEINS CONTENT IN TUMORS AND DISTANT TISSUES IN HER2/NEU TRANSGENIC MICE Open
The connection between circadian rhythms and cancer is bilateral at the body and cellular level. Negative impact of tumor development on circadian rhythms represents one of its aspects. Materials and methods. 16 FVB/N and 16 FVB/N transgen…
View article: Supplementary Material for: Gastric Cancer in <b><i>BRCA1</i></b> Germline Mutation Carriers: Results of Endoscopic Screening and Molecular Analysis of Tumor Tissues
Supplementary Material for: Gastric Cancer in <b><i>BRCA1</i></b> Germline Mutation Carriers: Results of Endoscopic Screening and Molecular Analysis of Tumor Tissues Open
Introduction: There is some evidence suggesting a link between BRCA1/2 germline mutations and increased risk of gastric cancer. Methods: Endoscopic screening for stomach malignancies was performed in 120 BRCA1 mutation carriers in order to…
View article: STUDY OF THE EFFECT OF LOMUSTIN ON HER2-POSITIVE BREAST CANCER IN FVB/N HER-2 TRANSGENIC MICE
STUDY OF THE EFFECT OF LOMUSTIN ON HER2-POSITIVE BREAST CANCER IN FVB/N HER-2 TRANSGENIC MICE Open
Because of the high risk of brain metastases from HER2-positive breast cancer, the study of the anticancer activity of drugs used to treat brain tumors, in particular lomustine, is of great importance. In the FVB/N Her-2 transgenic mice be…
View article: THE STUDY OF CIRCADIAN RHYTHMS IN OVARIAN CANCER RAT MODEL: IS THERE CONNECTION BETWEEN TUMOR DEVELOPMENT AND RHYTHMICITY DISRUPTION IN INTACT TISSUES?
THE STUDY OF CIRCADIAN RHYTHMS IN OVARIAN CANCER RAT MODEL: IS THERE CONNECTION BETWEEN TUMOR DEVELOPMENT AND RHYTHMICITY DISRUPTION IN INTACT TISSUES? Open
Considering emerging yet contradictory data on circadian rhythms disruption and its effects on tumor initiation and progression, we performed in vivo study to evaluate changes (if any) in clock genes expression in tumor compared to intact …
View article: MODIFICATING ACTION OF DICLOFENAC ON EFFECTS OF PHOTODYNAMIC THERAPY – IN VIVO STUDY
MODIFICATING ACTION OF DICLOFENAC ON EFFECTS OF PHOTODYNAMIC THERAPY – IN VIVO STUDY Open
Introduction. Non-steroidal anti-inflammatory drugs and, in particular, diclofenac, are considered as drugs with a potentially anticarcinogenic effect and can be used to enhance the effects of antitumor therapy. Aim. To evaluate the effect…
View article: Ascitic ovarian cancer is an adequate preclinical model of carcinomatosis to study intraperitoneal chemoperfusion treatment
Ascitic ovarian cancer is an adequate preclinical model of carcinomatosis to study intraperitoneal chemoperfusion treatment Open
To study the mechanisms underlying the effects of intraperitoneal chemoperfusion and to develop the optimal chemoperfusion regimen, an animal model of peritoneal carcinomatosis closely resembles a human model of peritoneal carcinomatosis i…
View article: The Effect of Polyphenolic Composition BP-C3 on the Efficacy and Hematological Toxicity of Cyclophosphamide in the Chemotherapy of Mice Bearing Soft Tissue Sarcomas Induced by Benzo[a]pyrene
The Effect of Polyphenolic Composition BP-C3 on the Efficacy and Hematological Toxicity of Cyclophosphamide in the Chemotherapy of Mice Bearing Soft Tissue Sarcomas Induced by Benzo[a]pyrene Open
This study aimed to evaluate the effect of lignin-derived polyphenolic composition BP-C3 on the efficacy and hematological toxicity of cyclophosphamide (CPA). Male and female Swiss-H derived mice bearing benzo[a]pyrene-induced soft tissue …
View article: CIRCADIAN RHYTHM OF PROLIFERATION IN INTESTINAL EPITHELIUM AND MAMMARY TUMORS IN HER-2/NEU TRANSGENIC AND FVB/N WILD TYPE MICE; THEIR CORRECTION WITH MELATONIN
CIRCADIAN RHYTHM OF PROLIFERATION IN INTESTINAL EPITHELIUM AND MAMMARY TUMORS IN HER-2/NEU TRANSGENIC AND FVB/N WILD TYPE MICE; THEIR CORRECTION WITH MELATONIN Open
Circadian rhythms and tumor development are interconnected as the factors like light pollution which disrupt circadian rhythms increase the risk of cancer, and oncological diseases are associated with changes in organism’s circadian rhythm…
View article: Novel water-soluble lignin derivative BP-Cx-1: identification of components and screening of potential targets <i>in silico</i> and <i>in vitro</i>
Novel water-soluble lignin derivative BP-Cx-1: identification of components and screening of potential targets <i>in silico</i> and <i>in vitro</i> Open
Identification of molecular targets and mechanism of action is always a challenge, in particular - for natural compounds due to inherent chemical complexity. BP-Cx-1 is a water-soluble modification of hydrolyzed lignin used as the platform…
View article: BP-C3 POLYPHENOLIC COMPOSITION INFLUENCE ON DYNAMICS OF 5-FLUOROURACIL INDUCED DAMAGE IN SMALL INTESTINE EPITHELIUM IN MICE
BP-C3 POLYPHENOLIC COMPOSITION INFLUENCE ON DYNAMICS OF 5-FLUOROURACIL INDUCED DAMAGE IN SMALL INTESTINE EPITHELIUM IN MICE Open
Chemotherapeutic drugs negatively influence on normal tissues with high proliferative activity such as intestinal epithelium. The damage of chemotherapy to healthy tissues significantly reduces oncological patients’ quality of life. Drugs …
View article: Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice
Effect of the polyphenol composition BP‑C3 on haematological and intestinal indicators of 5‑fluorouracil toxicity in mice Open
BP-C3 is a formulation, which comprises lignin-derived polyphenolic composition of benzenepolycarboxylic acids (BP-Cx-1) with iron complex, selenium, ascorbic acid and retinol, and possesses geroprotective activity. The present study exami…
View article: Radioprotective and radiomitigative effects of BP-C2, a novel lignin-derived polyphenolic composition with ammonium molybdate, in two mouse strains exposed to total body irradiation
Radioprotective and radiomitigative effects of BP-C2, a novel lignin-derived polyphenolic composition with ammonium molybdate, in two mouse strains exposed to total body irradiation Open
BP-C2 mitigates radiation-induced damage in mid-lethal range of radiation doses. Effects are mediated by enhancement of extramedullar hematopoiesis in the spleen and a protective effect on the intestinal epithelium.
View article: EFFECT OF ε-AMINOCAPROIC ACID ON THE GROWTH OF AN INOCULATED ASCITIC AND SOLID EHRLICH TUMOR OF MICE
EFFECT OF ε-AMINOCAPROIC ACID ON THE GROWTH OF AN INOCULATED ASCITIC AND SOLID EHRLICH TUMOR OF MICE Open
The antitumor activity of the antifibrinolytic drug ε-aminocaproic acid (ACC) in the therapeutic form (5% ACC solution in physiological solution instead of drinking water) was studied in the ascitic and solid Ehrlich tumor. ACC did not aff…
View article: OPEN TECHNIQUE OF HYPERTHERMIC INTRAPERITONEAL CHEMOPERFUSION IN TREATMENT OF PERITONEAL CARCINOMATOSIS IN RATS WITH ASCITIC OVARIAN TUMOR
OPEN TECHNIQUE OF HYPERTHERMIC INTRAPERITONEAL CHEMOPERFUSION IN TREATMENT OF PERITONEAL CARCINOMATOSIS IN RATS WITH ASCITIC OVARIAN TUMOR Open
For the first time comparative study of open and closed techniques of hyperthermic intraperitoneal chemoperfusion (HIPEC) in terms of safety and efficacy was performed in a rat model of ascetic ovarian cancer transplanted intraperitoneally…