Mikhail Myshkin
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View article: A Rapid Method for Detection of Antigen-Specific B Cells
A Rapid Method for Detection of Antigen-Specific B Cells Open
The global SARS-CoV-2 pandemic has united the efforts of many scientists all over the world to develop wet-lab techniques and computational approaches aimed at the identification of antigen-specific T and B cells. The latter provide specif…
View article: New Three-Finger Protein from Starfish Asteria rubens Shares Structure and Pharmacology with Human Brain Neuromodulator Lynx2
New Three-Finger Protein from Starfish Asteria rubens Shares Structure and Pharmacology with Human Brain Neuromodulator Lynx2 Open
Three-finger proteins (TFPs) are small proteins with characteristic three-finger β-structural fold stabilized by the system of conserved disulfide bonds. These proteins have been found in organisms from different taxonomic groups and perfo…
View article: Probing GFP Chromophore Analogs as Anti-HIV Agents Targeting LTR-III G-Quadruplex
Probing GFP Chromophore Analogs as Anti-HIV Agents Targeting LTR-III G-Quadruplex Open
Green fluorescent protein (GFP) chromophore and its congeners draw significant attention mostly for bioimaging purposes. In this work we probed these compounds as antiviral agents. We have chosen LTR-III DNA G4, the major G-quadruplex (G4)…
View article: Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins
Dodecapeptide Cathelicidins of Cetartiodactyla: Structure, Mechanism of Antimicrobial Action, and Synergistic Interaction With Other Cathelicidins Open
In this study, dodecapeptide cathelicidins were shown to be widespread antimicrobial peptides among the Cetruminantia clade. In particular, we investigated the dodecapeptide from the domestic goat Capra hircus , designated as ChDode and it…
View article: Voltage-Sensing Domain of the Third Repeat of Human Skeletal Muscle NaV1.4 Channel As a New Target for Spider Gating Modifier Toxins
Voltage-Sensing Domain of the Third Repeat of Human Skeletal Muscle NaV1.4 Channel As a New Target for Spider Gating Modifier Toxins Open
Voltage-gated sodium channels (NaV) have a modular architecture and contain five membrane domains. The central pore domain is responsible for ion conduction and contains a selectivity filter, while the four peripheral voltage-sensing domai…
View article: Cell-Free Expression of Sodium Channel Domains for Pharmacology Studies. Noncanonical Spider Toxin Binding Site in the Second Voltage-Sensing Domain of Human Nav1.4 Channel
Cell-Free Expression of Sodium Channel Domains for Pharmacology Studies. Noncanonical Spider Toxin Binding Site in the Second Voltage-Sensing Domain of Human Nav1.4 Channel Open
Voltage-gated sodium (NaV) channels are essential for the normal functioning of cardiovascular, muscular, and nervous systems. These channels have modular organization; the central pore domain allows current flow and provides ion selectivi…
View article: Abstract OR-1: NMR Spectroscopy: Alternative Method for Structural Studies of Highly Dynamic Membrane Proteins and Ion Channels
Abstract OR-1: NMR Spectroscopy: Alternative Method for Structural Studies of Highly Dynamic Membrane Proteins and Ion Channels Open
Background: Integral membrane proteins (IMPs) play key roles in a variety of biological processes essential for living cells and multicellular organisms. Despite the intensive studies, the molecular mechanisms of IMPs functioning are not v…
View article: Spider toxin inhibits gating pore currents underlying periodic paralysis
Spider toxin inhibits gating pore currents underlying periodic paralysis Open
Significance Voltage-gated ion channels contain domains that have discrete functionalities. The central pore domain allows current flow and provides ion selectivity, whereas peripherally located voltage-sensing domains (VSDs) are needed fo…