Mikiko Aoki
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View article: Histiocytic Sarcoma: A Review and Update
Histiocytic Sarcoma: A Review and Update Open
Histiocytic sarcoma (HS) is an ultra-rare hematopoietic neoplasm that frequently occurs in extranodal sites of adults. Clinically, HS demonstrates aggressive behavior and can arise de novo or in association with other hematological neoplas…
View article: Lipofibromatosis Revisited
Lipofibromatosis Revisited Open
Lipofibromatosis (LPF) is a locally aggressive but non-metastasizing mesenchymal tumor that primarily occurs in the hands and feet of infants and young children. It typically presents as a slow-growing, painless, poorly demarcated subcutan…
View article: Difficulties of Differentiating Primary Histiocytic Sarcoma of the Central Nervous System from Glioblastoma in Older Patients: Methylation Analysis and Review of the Literature
Difficulties of Differentiating Primary Histiocytic Sarcoma of the Central Nervous System from Glioblastoma in Older Patients: Methylation Analysis and Review of the Literature Open
Primary histiocytic sarcoma of the central nervous system is an extremely rare malignancy, with only 43 cases reported to date. It often presents diagnostic challenges due to its rarity and similarities with other central nervous system tu…
View article: Bizarre Parosteal Osteochondromatous Proliferation Revisited
Bizarre Parosteal Osteochondromatous Proliferation Revisited Open
Bizarre parosteal osteochondromatous proliferation (BPOP) is a rare benign surface-based bone lesion that primarily occurs in the hands and feet of young and early middle-aged adults. The lesion presents as a firm, usually painless mass of…
View article: Growing teratoma syndrome arising from malignant mixed germ cell tumor: Case report and review of literature
Growing teratoma syndrome arising from malignant mixed germ cell tumor: Case report and review of literature Open
View article: Two Cases of Tumor-induced Osteomalacia Resulting in Surgical Resection during Burosumab Therapy
Two Cases of Tumor-induced Osteomalacia Resulting in Surgical Resection during Burosumab Therapy Open
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome that results from tumors that secrete fibroblast growth factor 23 (FGF23). This leads to chronic hypophosphatemia. Burosumab, an anti-FGF23 antibody, is an effective treatm…
View article: Fibroma of Tendon Sheath Revisited
Fibroma of Tendon Sheath Revisited Open
Fibroma of tendon sheath (FTS) is a benign fibroblastic/myofibroblastic neoplasm that primarily occurs in the fingers and hands of young and middle-aged adults. The lesion typically presents as a small, firm, slow-growing, painless nodule.…
View article: Intraventricular Pilocytic Astrocytoma in a 75-Year-Old Adult Patient: A Case Report
Intraventricular Pilocytic Astrocytoma in a 75-Year-Old Adult Patient: A Case Report Open
View article: A Case of Intracranial Mesenchymal Tumor, FET::CREB Fusion-positive, Diagnosed by Genomic Profiling with FoundationOne CDx
A Case of Intracranial Mesenchymal Tumor, FET::CREB Fusion-positive, Diagnosed by Genomic Profiling with FoundationOne CDx Open
Intracranial mesenchymal tumor FET::cyclic adenosine monophosphate response element-binding fusion-positive is a soft tissue tumor with an extremely rare intracranial occurrence. Histological diagnosis is sometimes difficult, requiring con…
View article: Invasive Tracheobronchial Aspergillosis: A Fatal Complication in a Patient With Treated Mediastinal Lung Adenocarcinoma
Invasive Tracheobronchial Aspergillosis: A Fatal Complication in a Patient With Treated Mediastinal Lung Adenocarcinoma Open
View article: Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update
Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update Open
Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. It has locally recurr…
View article: Inhibitory Effect of Pyra–Metho–Carnil on the Differentiation and Maturation of Macrophages in Normal and Cancer Microenvironments
Inhibitory Effect of Pyra–Metho–Carnil on the Differentiation and Maturation of Macrophages in Normal and Cancer Microenvironments Open
The high level of in vivo tumor suppression caused by PMC may be due to inhibition of the differentiation and maturation of tumor-associated macrophages via the NF[Formula: see text]B signaling pathway.
View article: Keratin-Positive Giant Cell-Rich Tumor: A Review and Update
Keratin-Positive Giant Cell-Rich Tumor: A Review and Update Open
Keratin-positive giant cell-rich tumor (KPGCT) is an extremely rare and recently described mesenchymal neoplasm that occurs in both soft tissue and bone, frequently found in young women. It has locally recurrent potential if incompletely e…
View article: A case of giant nipple adenoma
A case of giant nipple adenoma Open
View article: Biology and Management of Deep-seated Atypical Lipomatous Tumor of the Extremities
Biology and Management of Deep-seated Atypical Lipomatous Tumor of the Extremities Open
Adipocytic neoplasms are frequently encountered in clinical practice. Atypical lipomatous tumor (ALT) is a locally aggressive but non-metastasizing adipocytic neoplasm that primarily occurs in the proximal extremities of middle-aged to old…
View article: MMP-2 Regulation of Emmprin on Tumour Cells and CD73 on Fibroblasts During Tumour-Stromal Interaction
MMP-2 Regulation of Emmprin on Tumour Cells and CD73 on Fibroblasts During Tumour-Stromal Interaction Open
CD73 on fibroblasts acts as a receptor for emmprin, which forms a complex that increases MMP-2 production, possibly resulting in increased invasiveness.
View article: A Case of Hibernoma in the Neck
A Case of Hibernoma in the Neck Open
25 歳，男性。1 カ 月前より頚部から左肩にかけて弾性軟な腫瘤を自覚し当院を受診した。MRI 検査では左腋窩から鎖骨上窩にかけて境界明瞭な約 10 cm の腫瘤様病変を認め，内部は T1WI で等～高信号，STIR では不均一な低～高信号，DWI でごく淡い信号上昇，血管と思われる索状構造の貫通を認めた。脂肪性腫瘍が疑われ全身麻酔下で切除した。切除した腫瘍は弾性軟で黄色調の腫瘍内にやや硬く褐色調の部が混在していた。病理組織所見では好酸性顆粒状胞体を含む細胞や泡沫状胞体を含…
View article: Spindle Cell Lipoma and Pleomorphic Lipoma: An Update and Review
Spindle Cell Lipoma and Pleomorphic Lipoma: An Update and Review Open
Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. SCL and pleomorphic lipoma (PL) represent a morphological spec…
View article: Supplementary Figure 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 328K, A case of MPNST (left) arising from neurofibroma (right) in patients with neurofibromatosis type 1. Most MPNST cells are positive for p-AKT, p-mTOR, p-S6RP, p-p70S6K, and p-4E-BP1. Meanwhile, most tumor cells in the neurof…
View article: Supplementary Figure 3 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 3 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 182K, The Kaplan-Meier curves for overall survival according to p-p70S6K, p-4E-BP1, p-MEK1/2, and p-ERK1/2 expressions. Immunoreactivity for p-p70S6K, p-4E-BP1, p-MEK1/2, and p-ERK1/2 fails to show a significant difference in ov…
View article: Supplementary Table 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Table 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
XLSX file - 9K, A comparison of p-Akt, p-mTOR, p-S6RP, p-p70S6K and p-4E-BP1 expression results in all specimens
View article: Supplementary Figure Legend from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure Legend from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 72K
View article: Supplementary Figure 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 1 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 328K, A case of MPNST (left) arising from neurofibroma (right) in patients with neurofibromatosis type 1. Most MPNST cells are positive for p-AKT, p-mTOR, p-S6RP, p-p70S6K, and p-4E-BP1. Meanwhile, most tumor cells in the neurof…
View article: Supplementary Table 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Table 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
XLSX file - 9K, Multiivariate analysis for overall survival with p-AKT expression
View article: Supplementary Figure Legend from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure Legend from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 72K
View article: Supplementary Figure 5 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 5 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 3331K, Representative examples of Everolimus-induced change in the activation of the AKT/mTOR and MAPK pathways assessed by immunocytochemistry. Decreased p-S6RP and p-p70S6K expressions by Everolimus (30 nM, a dose achievable i…
View article: Supplementary Figure 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 268K, Western blotting (WB) for p-AKT, (total) AKT, p-mTOR, (total) mTOR, p-S6RP, p-p70S6K, p-MEK1/2, and p-ERK1/2 using frozen tumor samples and corresponding normal tissue. Positive or negative staining (P: positive; N: negati…
View article: Supplementary Figure 4 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 4 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 385K, Everolimus-induced change in the activation status of the AKT/mTOR and MAPK pathways evaluated by Western blotting. Decreased p-S6RP and p-p70S6K expressions by Everolimus (30 nM, a dose achievable in humans by oral admini…
View article: Supplementary Figure 3 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 3 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 182K, The Kaplan-Meier curves for overall survival according to p-p70S6K, p-4E-BP1, p-MEK1/2, and p-ERK1/2 expressions. Immunoreactivity for p-p70S6K, p-4E-BP1, p-MEK1/2, and p-ERK1/2 fails to show a significant difference in ov…
View article: Supplementary Figure 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors
Supplementary Figure 2 from Prognostic Significance of AKT/mTOR and MAPK Pathways and Antitumor Effect of mTOR Inhibitor in NF1-Related and Sporadic Malignant Peripheral Nerve Sheath Tumors Open
PDF file - 268K, Western blotting (WB) for p-AKT, (total) AKT, p-mTOR, (total) mTOR, p-S6RP, p-p70S6K, p-MEK1/2, and p-ERK1/2 using frozen tumor samples and corresponding normal tissue. Positive or negative staining (P: positive; N: negati…