Mikkel Nygaard
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View article: Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns
Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns Open
NCT03322761, NCT02661555, NCT04762342, NCT04356248, DRKS00017091, DRKS00031445, DRKS00028792, DRKS00029105.
View article: Persons with multiple sclerosis reveal distinct kynurenine pathway metabolite patterns: a multinational cross-sectional study
Persons with multiple sclerosis reveal distinct kynurenine pathway metabolite patterns: a multinational cross-sectional study Open
Neuroaxonal damage in multiple sclerosis (MS) results from an interplay of neurotoxic pathomechanisms combined with a reduced neuroprotective capacity of neurons and glia to resist neurotoxic damage. Kynurenine pathway (KP) imbalance resem…
View article: Differentiation of MS lesions through analysis of microvascular distribution
Differentiation of MS lesions through analysis of microvascular distribution Open
Conventional MRI is crucial for diagnosing multiple sclerosis (MS) but lacks precision, leading to the clinico-radiological paradox and misdiagnosis risk, especially when confronted with unspecific lesions not related to MS. Advancements i…
View article: Clinical, Neurophysiological, and MRI Markers of Fampridine Responsiveness in Multiple Sclerosis—An Explorative Study
Clinical, Neurophysiological, and MRI Markers of Fampridine Responsiveness in Multiple Sclerosis—An Explorative Study Open
Objective: Persons with multiple sclerosis (PwMS), already established as responders or non-responders to Fampridine treatment, were compared in terms of disability measures, physical and cognitive performance tests, neurophysiology, and m…
View article: Study protocol: randomised controlled trial evaluating exercise therapy as a supplemental treatment strategy in early multiple sclerosis: the Early Multiple Sclerosis Exercise Study (EMSES)
Study protocol: randomised controlled trial evaluating exercise therapy as a supplemental treatment strategy in early multiple sclerosis: the Early Multiple Sclerosis Exercise Study (EMSES) Open
Introduction In the relapsing remitting type of multiple sclerosis (MS) reducing relapses and neurodegeneration is crucial in halting the long-term impact of the disease. Medical disease-modifying treatments have proven effective, especial…
View article: Efficacy of High-Intensity Aerobic Exercise on Brain MRI Measures in Multiple Sclerosis
Efficacy of High-Intensity Aerobic Exercise on Brain MRI Measures in Multiple Sclerosis Open
This study provides Level I evidence that 24 weeks of high-intensity PAE did not elicit disease-modifying effects in PBVC in people with MS. Exploratory analyses showed that PAE may reduce relapse rate.
View article: A cross-sectional comparison of performance, neurophysiological and MRI outcomes of responders and non-responders to fampridine treatment in multiple sclerosis – An explorative study
A cross-sectional comparison of performance, neurophysiological and MRI outcomes of responders and non-responders to fampridine treatment in multiple sclerosis – An explorative study Open
View article: Efficacy of High-Intensity Progressive Aerobic Exercise on Brain Atrophy Measures in Multiple Sclerosis: A Randomized, Controlled, Cross-Over, Phase-2 Trial
Efficacy of High-Intensity Progressive Aerobic Exercise on Brain Atrophy Measures in Multiple Sclerosis: A Randomized, Controlled, Cross-Over, Phase-2 Trial Open