Mikko Hippeläinen
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View article: NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli
NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli Open
Aims Oxidized phospholipids and microRNAs (miRNAs) are increasingly recognized to play a role in endothelial dysfunction driving atherosclerosis. NRF2 transcription factor is one of the key mediators of the effects of oxidized phospholipid…
View article: Purchases of medical therapy recommended for coronary artery disease before and after elective revascularisation
Purchases of medical therapy recommended for coronary artery disease before and after elective revascularisation Open
Aims We studied the purchases of medical therapy recommended for coronary artery disease patients before and after elective revascularisation (percutaneous coronary intervention (PCI) or coronary bypass grafting (CABG)). Methods All patien…
View article: NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation
NRF2 regulates endothelial glycolysis and proliferation with miR-93 and mediates the effects of oxidized phospholipids on endothelial activation Open
Phospholipids, such as 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC), are the major components of cell membranes. Their exposure to reactive oxygen species creates oxidized phospholipids, which predispose to the development…
View article: Does routinely collected patient-reported outcome data represent the actual case-mix of elective coronary revascularization patients?
Does routinely collected patient-reported outcome data represent the actual case-mix of elective coronary revascularization patients? Open
Routinely collected PROs in cardiac patients may be biased towards younger and healthier patients. This needs to be recognized when evaluating the representativeness of such data. The routine collection of these data should be adequately r…
View article: Representativeness of Routinely Collected Patient-Reported Outcome Data in Coronary Revascularization Patients?
Representativeness of Routinely Collected Patient-Reported Outcome Data in Coronary Revascularization Patients? Open
View article: Spectral Entropy Parameters during Rapid Ventricular Pacing for Transcatheter Aortic Valve Implantation
Spectral Entropy Parameters during Rapid Ventricular Pacing for Transcatheter Aortic Valve Implantation Open
The time-frequency balanced spectral entropy of the EEG is a monitoring technique measuring the level of hypnosis during general anesthesia. Two components of spectral entropy are calculated: state entropy (SE) and response entropy (RE). T…
View article: Comparison of EQ-5D and 15D instruments for assessing the health-related quality of life in cardiac surgery patients
Comparison of EQ-5D and 15D instruments for assessing the health-related quality of life in cardiac surgery patients Open
EQ-5D and 15D do not appear to be interchangeable when patient-centred outcomes in CABG patients are assessed. The EQ-5D seems to have better discriminative power and known-group validity, whereas the 15D is more sensitive to change over t…
View article: MicroRNA Profiling of Pericardial Fluid Samples from Patients with Heart Failure
MicroRNA Profiling of Pericardial Fluid Samples from Patients with Heart Failure Open
Measured microRNA profiles did not separate the samples according to the clinical features of the patients. However, several previously identified heart failure marker microRNAs were detected. The pericardial fluid microRNA profile appeare…
View article: New-onset atrial fibrillation at discharge in patients after coronary artery bypass surgery: short- and long-term morbidity and mortality
New-onset atrial fibrillation at discharge in patients after coronary artery bypass surgery: short- and long-term morbidity and mortality Open
A majority of NOAF patients revert to SR during the first months after surgery. On the other hand, 20-25% of NOAF patients develop chronic AF during long-term follow-up. Almost half of the NOAF patients were hospitalized during follow-up d…