Explanipedia

Effects of in vivo chlorobenzene exposure on bone tissue in a rat model Open

Krisztián Sepp, Péter Hausinger, Béla Hegedüs, Péter Sándor Kiss, Edina Cseszkó , et al. · 2025

Calcipaenic bone disorders (e.g., osteoporosis) are becoming an epidemic as a significant public health concern. The underlying genetic, epigenetic, and homeostatic factors and the determinants of bone tissue expression are triggered by en…

Renal Epithelial Complement C3 Expression Affects Kidney Fibrosis Progression Open

Ganna Stepanova, Anna Manzéger, Miklós Mózes, Gábor Kökény · 2024

Kidney fibrosis is a hallmark of chronic kidney diseases. Evidence shows that genetic variability and complement component 3 (C3) might influence tubulointerstitial fibrosis. Still, the role of renal C3 production in the epithelial-to-mese…

Study of endocrine disruptor effects in AVP and OT mediated behavioral and reproductive processes in female rat models Open

Krisztián Sepp, Anna László, Márta Gálfi, Marianna Radács, Miklós Mózes , et al. · 2024

Environmental exposures may have endocrine disruptor (ED) effects, e.g., a role for halogenated hydrocarbon chlorobenzenes in increasing vasopressin (AVP), oxytocin (OT) secretion and, in association, anxiety and aggression in male rats ha…

Pioglitazone Protects Tubular Epithelial Cells during Kidney Fibrosis by Attenuating miRNA Dysregulation and Autophagy Dysfunction Induced by TGF-β Open

Anna Manzéger, Gantsetseg Garmaa, Miklós Mózes, Georg Hansmann, Gábor Kökény · 2023

Excessive renal TGF-β production and pro-fibrotic miRNAs are important drivers of kidney fibrosis that lack any efficient treatment. Dysfunctional autophagy might play an important role in the pathogenesis. We aimed to study the yet unknow…

#5503 PIOGLITAZONE REVERSES MIR-130A AND MIR-199 DYSREGULATION INDUCED BY TGF-BETA DURING KIDNEY FIBROSIS Open

Miklós Mózes, Gantsetseg Garmaa, Anna Manzéger, Gábor Kökény · 2023

Background and Aims The peroxisome proliferator-activated receptor-γ (PPARγ) agonists have been shown to dampen TGF-β signaling and suppress miR-130a in VSMCs and also profibrotic miR-21-5p in the kidney. We have recently demonstrated that…

Susceptibility to kidney fibrosis in mice is associated with early growth response-2 protein and tissue inhibitor of metalloproteinase-1 expression Open

Gábor Kökény, Ágnes Németh, Jeffrey B. Kopp, Weiping Chen, Andrew J. Oler , et al. · 2022

Patients with chronic kidney disease and experimental animal models of kidney fibrosis manifest diverse progression rates. Genetic susceptibility may contribute to this diversity, but the causes remain largely unknown. We have previously d…

MO612: Relationship of Renal Timp-1, Stat3 and Inflammatory Factors in Diabetes Open

Anna Manzéger, Krisztina Mikone, Miklós Mózes, Ganna Stepanova, Gábor Kökény · 2022

BACKGROUND AND AIMS The balance of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMP) is disrupted in diabetic nephropathy and renal TIMP-1 overexpression is observed in both animal experimental models and human biopsies. …

MO404: Autophagy and Fibrotic Response is Genetically Determined in Mouse Mesangial Cells Open

Anna Manzéger, Krisztina Mikone, Miklós Mózes, Gábor Kökény · 2022

BACKGROUND AND AIMS C57Bl6/J (B6) mouse strain is resistant to several experimental models of renal fibrosis. Mesangial cells play an important role in the pathogenesis of glomerulosclerosis. Also, autophagy dysregulation was recently rela…

P0721PPAR-GAMMA ACTIVATION INHIBITS TGF-BETA INDUCED RENAL COMPLEMENT AND GALECTIN-3 EXPRESSION IN VIVO AND IN VITRO Open

Helga Popovics, Krisztina Mikone, Miklós Mózes, JiYeon Kwon, Georg Hansmann , et al. · 2020

Background and Aims Reduced peroxisome proliferator-activated receptor-γ (PPARγ) activity has been observed in chronic kidney disease and fibrosis. We have recently shown that the PPARγ agonist pioglitazone dampens TGF-β induced renal pro-…

P0681TIMP-1 DEFICIENCY DAMPENS RENAL GALECTIN-3 RESPONSE IN DIABETES Open

Gábor Kökény, Helga Popovics, Krisztina Mikone, Miklós Mózes · 2020

Background and Aims Overexpression of tissue inhibitors of metalloproteases (TIMPs) are a hallmark of renal fibrosis, and elevated TIMP-1 has been reported in experimental and human diabetes. Also, renal galectin-3 (Lgals3) overproduction …

The PPARγ agonist pioglitazone prevents TGF-β induced renal fibrosis by repressing EGR-1 and STAT3 Open

Ágnes Németh, Miklós Mózes, Laurent Calvier, Georg Hansmann, Gábor Kökény · 2019

FP345TIMP-1 DEFICIENCY REDUCES TGF-BETA EXPRESSION AND DAMPENS RENAL FIBROSIS AFTER RENAL ABLATION Open

Ágnes Németh, Kinga Tasnady, Miklós Mózes, László Rosivall, Gábor Kökény · 2019

SP257EARLY RENAL INFLAMMATORY MOLECULE EXPRESSION DIFFERENCES AFTER UNILATERAL URETER OBSTRUCTION IN MICE Open

Gábor Kökény, Amelia Foss, Ágnes Németh, Krisztina Fazekas, Miklós Mózes · 2018

SP270GENETIC SUSCEPTIBILITY TO TGF-BETA INDUCED RENAL FIBROSIS IS ASSOCIATED WITH ALTERED MIR-199 EXPRESSION Open

Miklós Mózes, Ágnes Németh, Krisztina Fazekas, Gábor Kökény · 2018

Sustained hyperosmolarity increses TGF-ß1 and Egr-1 expression in the rat renal medulla Open

Miklós Mózes, Petra Szoleczky, László Rosivall, Gábor Kökény · 2017

We conclude that both TGF-ß and Egr-1 are upregulated by sustained hyperosmolarity in the rat renal medulla, and it favors the expression of extracellular matrix components.

SP271PIOGLITAZONE EFFECTIVELY REDUCES RENAL INTERSTITIAL FIBROSIS IN TGF-ß TRANSGENIC MICE Open

Ágnes Németh, Gábor Kökény, Krisztina Fazekas, Amelia Foss, Attila Tordai , et al. · 2017

MP051GENETIC BACKGROUND DETERMINES MURINE PRIMARY MESANGIAL CELL RESPONSE TO TGF-ß Open

Gábor Kökény, Krisztina Fazekas, Petra Szoleczky, Miklós Mózes · 2017

PPARγ Links BMP2 and TGFβ1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism Open

Laurent Calvier, Philippe Chouvarine, Ekaterina Legchenko, Nadine Hoffmann, Jonas Geldner , et al. · 2017

MP360DELAYED PROGRESSION OF RENAL FIBROSIS IN C57BL6/J MICE IS ASSOCIATED WITH ROBUST MMP ACTIVITY Open

Miklós Mózes, Amelia Foss, Krisztina Fazekas, Gábor Kökény · 2017

MP097SUSTAINED HYPEROSMOLARITY LEADS TO THE EXPRESSION OF PROFIBROTIC FACTORS IN VIVO Open

Miklós Mózes, Krisztina Fazekas, Petra Szoleczky, Gábor Kökény · 2017

Ductular reaction correlates with fibrogenesis but does not contribute to liver regeneration in experimental fibrosis models Open

András Rókusz, Dániel Sándor Veres, Armanda Szücs, Edina Bugyik, Miklós Mózes , et al. · 2017

The stringent connection between ductular reaction and fibrosis, which cannot be influenced by any of our treatment regimens, suggests that there is a close mutual interaction between them instead of a unidirectional causal relationship. O…

The Effect of Combined Treatment with the (Pro)Renin Receptor Blocker HRP and Quinapril in Type 1 Diabetic Rats Open

Gábor Kökény, Lilla Fang, Csaba Révész, Miklós Mózes, Péter Vörös , et al. · 2017

Background/Aims: Diabetic nephropathy remains a major clinical problem. The effects of prorenin might be adverse, but the literature data are controversial. We compared the renal effects of the (pro)renin receptor ((P)RR) blo…

MP299EARLY AND SUSTAINED RUNX1 ACTIVATION AFTER UNILATERAL URETER OBSTRUCTION IN MICE: A POSSIBLE NEW PLAYER IN RENAL FIBROSIS Open

Miklós Mózes, Ágnes Németh, L Szabó, Krisztina Fazekas, Gábor Kökény · 2016

MP245MICRORNA NETWORKS IN THE PROGRESSION OF TGF-BETA INDUCED RENAL FIBROSIS Open

Gábor Kökény, Ágnes Németh, Krisztina Fazekas, Gábor Szénási, László Rosivall , et al. · 2016

Treatment protocols for LPS preconditioning. Open

Tamás Kaucsár, Bödör Csaba, Mária Godó, Csaba Szalay, Réka Csaba , et al. · 2015

Saline: physiological saline, LPS: bacterial lipopolysaccharide endotoxin, p: preconditioning dose, L: lethal dose, NB: novobiocin.

Western blot analysis of Hsp70 (A), and Hsp90 (B) protein expression. Open

Tamás Kaucsár, Bödör Csaba, Mária Godó, Szalay Csaba, Csaba Révész , et al. · 2015

Results are normalized to actin protein expression, and presented as fold increase relative to the saline-treated group with its mean set to 1. **, ***: p<0.01, 0.001 vs. the saline-treated controls, respectively, or between the groups ind…

Plasma urea levels at the time of organ harvest i.e. at 24 hours after the second treatment. Open

Tamás Kaucsár, Csaba Bödör, Mária Godó, Csaba Szalay, Csaba Révész , et al. · 2015

LPS: bacterial lipopolysaccharide endotoxin, p: preconditioning, L: lethal, NB: novobiocin. *, **, ***: p<0.05, 0.01, 0.001 vs. the saline-treated controls, respectively, or between the groups indicated.

Northern blot analysis of Hsp70 (A), Hsp90α (B) and Hsp90β (C) mRNA expression. Open

Tamás Kaucsár, Csaba Bödör, Mária Godó, Szalay Csaba, Csaba Révész , et al. · 2015

Results are normalized to S14 expression and presented as fold increase relative to the saline-treated group with its mean set to 1. *, **, ***: p<0.05, 0.01, 0.001 vs. the saline-treated controls, respectively, or between the groups indic…

FP301STRAIN-DEPENDENT RENAL COMPLEMENT EXPRESSION IN KIDNEY FIBROSIS OF TGF-ß TRASGENIC MICE Open

Gábor Kökény, Amelia Foss, Morgan Karetnick, János Szebeni, Ágnes Németh , et al. · 2015

FP307SUBTOTAL RENAL ABLATION INDUCES TUBULOINTERSTITIAL EGR-2 OVEREXPRESSION IN MICE Open

Gábor Kökény, Ágnes Németh, L Szabó, Krisztina Fazekas, László Rosivall , et al. · 2015

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