Milan Bhagat
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View article: Analysis of local aggressiveness and malignancy transformation potential of ameloblastoma through osteopontin and CD10 expression (Immunohistochemical research)
Analysis of local aggressiveness and malignancy transformation potential of ameloblastoma through osteopontin and CD10 expression (Immunohistochemical research) Open
Background: Ameloblastoma is a benign, slow-growing odontogenic neoplasia that can infiltrate soft tissue and penetrate bone. Molecular markers like IHC staining with Osteopontin and CD10 antibodies can help understand the abnormalities an…
View article: 222-E Integrative spatial multi-omics analysis of NSCLC tumor microenvironment identifies key features associated with response to immune checkpoint inhibitor therapy
222-E Integrative spatial multi-omics analysis of NSCLC tumor microenvironment identifies key features associated with response to immune checkpoint inhibitor therapy Open
Background The tumor microenvironment (TME) of non-small cell lung cancer (NSCLC) undergoing immune checkpoint inhibitor (ICI) treatment is poorly understood. Spatially-resolved single-cell analyses are necessary to identify co-enriched ce…
View article: Multi‐omic and spatial dissection of immunotherapy response groups in non‐small cell lung cancer
Multi‐omic and spatial dissection of immunotherapy response groups in non‐small cell lung cancer Open
The composition and activation status of the cellular milieu contained within the tumour microenvironment (TME) is becoming increasingly recognized as a driving factor for immunotherapy response. Here, we employed multiplex immunohistochem…
View article: 118 Delineation of spatial tissue signatures of immunotherapy response groups in non-small cell lung cancer (NSCLC)
118 Delineation of spatial tissue signatures of immunotherapy response groups in non-small cell lung cancer (NSCLC) Open
Background Lung cancers remain the leading cause of cancer related mortality and have a poor 5-year survival. Immunotherapies have led to durable benefit in a cohort of non-small cell lung cancer (NSCLC) patients. Identifying those patient…
View article: IL-2 stromal signatures dissect immunotherapy response groups in non-small cell lung cancer (NSCLC)
IL-2 stromal signatures dissect immunotherapy response groups in non-small cell lung cancer (NSCLC) Open
Introduction Immunotherapies, such as immune checkpoint inhibitors (ICI) have shown durable benefit in a subset of non-small cell lung cancer (NSCLC) patients. The mechanisms for this are not fully understood, however the composition and a…
View article: 745 High throughput tissue imaging and phenotyping by streamlined 8-plex staining and analysis of complex TMA samples
745 High throughput tissue imaging and phenotyping by streamlined 8-plex staining and analysis of complex TMA samples Open
Conclusions In this study, we highlighted the benefits of using a combination of well-characterized TMAs, a fast, optimized 8-plex mIHC protocol, and a detailed analysis pipeline to characterize the immune-response in a broad range of canc…
View article: 1990P Relationship of T-cells and macrophages in the tumour microenvironment across multiple tumour indications
1990P Relationship of T-cells and macrophages in the tumour microenvironment across multiple tumour indications Open
View article: Abstract 126: Multidimensional gene expression models for characterizing response and metastasis in solid tumor samples
Abstract 126: Multidimensional gene expression models for characterizing response and metastasis in solid tumor samples Open
Predicting response to standard of care therapies and new immunotherapies is enabled by tools that quantitatively analyze the complex heterogeneity of the tumor microenvironment. Current methods to do so primarily rely either on single gen…