Milan Obradović
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View article: Budget Impact of the LungFlag™ Predictive Risk Model for Lung Cancer Screening
Budget Impact of the LungFlag™ Predictive Risk Model for Lung Cancer Screening Open
Using LungFlag to identify candidates for lung cancer screening was estimated to save US$2.8 million over 5 years from a US commercial health plan perspective, largely attributable to reduced costs of treating advanced NSCLC.
View article: Insulin-like growth factor-1 reduces cardiac autosis through decreasing AMPK/FOXO1 signaling and Na+/K+-ATPase-Beclin-1 interaction
Insulin-like growth factor-1 reduces cardiac autosis through decreasing AMPK/FOXO1 signaling and Na+/K+-ATPase-Beclin-1 interaction Open
Introduction Insulin-like growth factor-1 (IGF-1) promotes survival and inhibits cardiac autophagy disruption. Methods Male Wistar rats were treated with IGF-1 (50 µg/kg), and 24 h after injection hearts were excised. The level of interact…
View article: AIR QUALITY ASSESSMENT IN BELGRADE: SPATIAL AND TEMPORAL VARIATIONS
AIR QUALITY ASSESSMENT IN BELGRADE: SPATIAL AND TEMPORAL VARIATIONS Open
Urban areas are particularly affected by polluted air. The objective of this research was to evaluate the air quality in Belgrade, focusing on the distinct distribution of pollutants across various locations during different seasons. The a…
View article: Nitric oxide, thyroglobulin, and calcitonin: unraveling the nature of thyroid nodules
Nitric oxide, thyroglobulin, and calcitonin: unraveling the nature of thyroid nodules Open
Background Thyroid nodules (TN) are localized morphological changes in the thyroid gland and can be benign or malignant. Objective The present study investigates the relationships between biochemical markers in serum (s) and their homologs…
View article: Autophagy and diabetes
Autophagy and diabetes Open
The current literature findings on autophagy’s beneficial and detrimental roles in diabetes mellitus (DM) and diabetes-related comorbidities were reviewed. The effects of oral hypoglycaemic medicines and autophagy in DM. Autophagy plays an…
View article: ECAP-controlled closed-loop versus open-loop SCS for the treatment of chronic pain: 36-month results of the EVOKE blinded randomized clinical trial
ECAP-controlled closed-loop versus open-loop SCS for the treatment of chronic pain: 36-month results of the EVOKE blinded randomized clinical trial Open
Introduction The evidence for spinal cord stimulation (SCS) has been criticized for the absence of blinded, parallel randomized controlled trials (RCTs) and limited evaluations of the long-term effects of SCS in RCTs. The aim of this study…
View article: The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases
The Na+/K+-ATPase: A potential therapeutic target in cardiometabolic diseases Open
Cardiometabolic diseases (CMD) are a direct consequence of modern living and contribute to the development of multisystem diseases such as cardiovascular diseases and diabetes mellitus (DM). CMD has reached epidemic proportions worldwide. …
View article: Editorial: Non-coding RNA in diabetes and cardiovascular diseases
Editorial: Non-coding RNA in diabetes and cardiovascular diseases Open
Editorial on the Research Topic: [https://www.frontiersin.org/research-topics/33365/non-coding-rna-in-diabetes-and-cardiovascular-diseases]
View article: Non-alcoholic Fatty Liver Disease, Metabolic syndrome, and Type 2 diabetes mellitus: Where do we stand today?
Non-alcoholic Fatty Liver Disease, Metabolic syndrome, and Type 2 diabetes mellitus: Where do we stand today? Open
Non-alcoholic fatty liver disease (NAFLD), metabolic syndrome (MetS), and type 2 diabetes (T2DM) are metabolic disorders that belong to highly prevalent disease cluster with a significant impact on public health worldwide. MetS is a comple…
View article: Role of C-Reactive Protein in Diabetic Inflammation
Role of C-Reactive Protein in Diabetic Inflammation Open
Even though type 2 diabetes mellitus (T2DM) represents a worldwide chronic health issue that affects about 462 million people, specific underlying determinants of insulin resistance (IR) and impaired insulin secretion are still unknown. Th…
View article: Durability of Clinical and Quality-of-Life Outcomes of Closed-Loop Spinal Cord Stimulation for Chronic Back and Leg Pain
Durability of Clinical and Quality-of-Life Outcomes of Closed-Loop Spinal Cord Stimulation for Chronic Back and Leg Pain Open
ECAP-controlled, closed-loop SCS, which elicited a more consistent neural response, was associated with sustained superior pain relief at 24 months, consistent with the 3- and 12-month outcomes.
View article: Antioxidant enzymes and vascular diseases
Antioxidant enzymes and vascular diseases Open
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a fundamental role in regulating endothelial function and vascular tone in the physiological conditions of a vascular system. However, oxidative stress has detrimental …
View article: Non-alcoholic fatty liver disease: a multidisciplinary clinical practice approach—the institutional adaptation to existing Clinical Practice Guidelines
Non-alcoholic fatty liver disease: a multidisciplinary clinical practice approach—the institutional adaptation to existing Clinical Practice Guidelines Open
Non-alcoholic fatty liver disease (NAFLD) is among the most frequently encountered chronic liver diseases in everyday clinical practice. It is considered the hepatic manifestation of metabolic syndrome. Today, liver biopsy is still the gol…
View article: Levothyroxine Treatment and the Risk of Cardiac Arrhythmias – Focus on the Patient Submitted to Thyroid Surgery
Levothyroxine Treatment and the Risk of Cardiac Arrhythmias – Focus on the Patient Submitted to Thyroid Surgery Open
Levothyroxine (LT4) is used to treat frequently encountered endocrinopathies such as thyroid diseases. It is regularly used in clinical (overt) hypothyroidism cases and subclinical (latent) hypothyroidism cases in the last decade. Suppress…
View article: Leptin and Obesity: Role and Clinical Implication
Leptin and Obesity: Role and Clinical Implication Open
The peptide hormone leptin regulates food intake, body mass, and reproductive function and plays a role in fetal growth, proinflammatory immune responses, angiogenesis and lipolysis. Leptin is a product of the obese ( ob ) gene and, follow…
View article: HbA1C as a marker of retrograde glycaemic control in diabetes patient with co‐existed beta‐thalassaemia: A case report and a literature review
HbA1C as a marker of retrograde glycaemic control in diabetes patient with co‐existed beta‐thalassaemia: A case report and a literature review Open
In thalassaemia and haemoglobinopathies, due to discrepancies in the five-point glycaemic profile and HbA1C values, it is necessary to measure HbA1C with a different method or to determine HbA1C and fructosamine simultaneously.
View article: Redox control of vascular biology
Redox control of vascular biology Open
Redox control is lost when the antioxidant defense system cannot remove abnormally high concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically elevated levels of ROS cause oxidative stress that may eventu…
View article: Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease
Glutathione “Redox Homeostasis” and Its Relation to Cardiovascular Disease Open
More people die from cardiovascular diseases (CVD) than from any other cause. Cardiovascular complications are thought to arise from enhanced levels of free radicals causing impaired “redox homeostasis,” which represents the interplay betw…
View article: Estradiol‐mediated regulation of hepatic iNOS in obese rats: Impact of Src, ERK1/2, AMPKα, and miR‐221
Estradiol‐mediated regulation of hepatic iNOS in obese rats: Impact of Src, ERK1/2, AMPKα, and miR‐221 Open
Purpose: This study aimed to investigate in vivo effects of estradiol on the regulation of hepatic inducible nitric oxide synthase (iNOS) expression in the high fat (HF) diet‐induced obesity. Also, we aimed to investigate whether activatio…
View article: Genetic Markers for Coronary Artery Disease
Genetic Markers for Coronary Artery Disease Open
Coronary artery disease (CAD) and myocardial infarction (MI) are recognized as leading causes of mortality in developed countries. Although typically associated with behavioral risk factors, such as smoking, sedentary lifestyle, and poor d…
View article: The role of the liver in glucose and lipid metabolism in obesity
The role of the liver in glucose and lipid metabolism in obesity Open
The liver plays a vital role in metabolic homeostasis and represents a major site for complex regulation of substrates (carbohydrates, lipids, and proteins) by insulin and other hormones. The significance of liver metabolic functions in ma…
View article: The role of eNOS and iNOS in pathophysiological conditions
The role of eNOS and iNOS in pathophysiological conditions Open
Nitric oxide (NO) is a free radical which, in reactions with various molecules causes multiple biological effects. NO is exceptionally regulated and extends to almost every cell type and function within circulation. Generation and actions …
View article: A quality of life assessment and the correlation between generic and disease-specific questionnaires scores in outpatients with chronic liver disease-pilot study
A quality of life assessment and the correlation between generic and disease-specific questionnaires scores in outpatients with chronic liver disease-pilot study Open
Introduction. Chronic liver diseases (CLD) are an important cause of morbidity and mortality in general population. The aim of this study was to analyze potential differences between patients with CLD and healthy control group, and to esti…
View article: Chronic idiopathic portal vein thrombosis: A case study
Chronic idiopathic portal vein thrombosis: A case study Open
Portal vein thrombosis (PVT) is a rare disorder of splanchnic circulation, frequently caused by concomitant presence of local and/or systemic factors. When portal vein thrombosis complicates causative diseases, it will worsen their prognos…