Milan R. Voško
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View article: Intrathecal Triamcinolone for Lumbar Degenerative Disease: A Single-Center Retrospective Cohort of 499 Patients
Intrathecal Triamcinolone for Lumbar Degenerative Disease: A Single-Center Retrospective Cohort of 499 Patients Open
Background/Objectives: While epidural and periradicular corticosteroid injections are well-established treatments for degenerative spinal conditions, intrathecal administration of glucocorticoids remains uncommon and under-researched. To o…
View article: C-REGS2—A multinational, high-quality comparative effectiveness study of Cerebrolysin in moderate acute ischemic stroke
C-REGS2—A multinational, high-quality comparative effectiveness study of Cerebrolysin in moderate acute ischemic stroke Open
Background: The main objective of the Cerebrolysin REGistry Study in Stroke 2 (C-REGS2) was to systematically record the routine clinical use of Cerebrolysin in patients with moderate ischemic stroke (IS) following the principles of a pros…
View article: External validation of the MR PREDICTS@24H model: predicting functional outcome after endovascular treatment in stroke
External validation of the MR PREDICTS@24H model: predicting functional outcome after endovascular treatment in stroke Open
Background Chalos et al recently developed the MR PREDICTS@24H model to predict 90 days functional outcomes in ischaemic stroke patients following endovascular treatment (EVT). We aimed to validate this model in the real-world situation of…
View article: Serum neurofilament light chain predicts disease severity in axonal variants of acute immune neuropathies: A retrospective monocentric cohort study
Serum neurofilament light chain predicts disease severity in axonal variants of acute immune neuropathies: A retrospective monocentric cohort study Open
Background and purpose The purpose was to explore the prognostic utility of neurofilament light chain (NfL) in patients with immune‐mediated polyradiculoneuropathies (IMPs). Methods This retrospective monocentric study analysed serum and c…
View article: Robotic-Assisted Transcranial Doppler Monitoring in Acute Neurovascular Care: a Feasibility and Safety Study
Robotic-Assisted Transcranial Doppler Monitoring in Acute Neurovascular Care: a Feasibility and Safety Study Open
Introduction: Transcranial Color Doppler (TCD) is currently the only non-invasive bedside tool capable of providing real-time information on cerebral hemodynamics. However, being operator dependent, TCD monitoring is not feasible in many i…
View article: Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion
Distance to thrombus, ischemic lesion volume and clinical outcome after thrombectomy for M1 middle cerebral artery occlusion Open
Summary Background Stroke resulting from occlusion of the middle cerebral artery (MCA) can have devastating consequences, potentially leading to a loss of independence. This study aimed to investigate the relationship between the distance …
View article: Endothelial receptor proteins in acute venous thrombosis and delayed thrombus resolution in cerebral sinus vein thrombosis
Endothelial receptor proteins in acute venous thrombosis and delayed thrombus resolution in cerebral sinus vein thrombosis Open
Background and purpose Cerebral sinus venous thrombosis (CSVT) is a rare but life-threatening disease and its diagnosis remains challenging. Blood biomarkers, including D-Dimer are currently not recommended in guidelines. Soluble endotheli…
View article: Effect of concomitant usage of alteplase and mechanical thrombectomy for M1 middle cerebral artery occlusion on clinical outcome: a retrospective analysis of 457 patients from two centers
Effect of concomitant usage of alteplase and mechanical thrombectomy for M1 middle cerebral artery occlusion on clinical outcome: a retrospective analysis of 457 patients from two centers Open
Introduction Endovascular thrombectomy (EVT) and concomitant usage of intravenous alteplase (alteplase) in large vessel occlusion stroke may produce unwanted excess intracerebral hemorrhage (ICH). Whether this applies specifically to isola…
View article: Risk of stroke in patients with prior VKA or DOAC: A population-based real-world registry analysis
Risk of stroke in patients with prior VKA or DOAC: A population-based real-world registry analysis Open
Introduction: To date, risk assessment of suffering ischemic and hemorrhagic stroke in individuals under oral anticoagulation (OAC) is limited to hospital-based cohorts and patients with atrial fibrillation. Patients and methods: Through t…
View article: Endothelial receptor proteins in acute venous thrombosis and delayed thrombus resolution in cerebral sinus vein thrombosis
Endothelial receptor proteins in acute venous thrombosis and delayed thrombus resolution in cerebral sinus vein thrombosis Open
Background and Purpose Cerebral sinus venous thrombosis (CSVT) is a rare but life-threatening disease and its diagnosis remains challenging. Blood biomarkers, including D-Dimer are currently not recommended in guidelines. Soluble endotheli…
View article: Systemische Lysetherapie (rtPA) des ischämischen Schlaganfalls bei Patient:innen unter oraler Antikoagulation
Systemische Lysetherapie (rtPA) des ischämischen Schlaganfalls bei Patient:innen unter oraler Antikoagulation Open
Zusammenfassung Die systemische Thrombolyse ist eine effektive und häufige Rekanalisationstherapie des akuten ischämischen Schlaganfalles. Eine Antikoagulation ist traditionell eine der typischen Kontraindikationen für die Anwendung der Ly…
View article: Temporal Trends of Functional Outcome in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis
Temporal Trends of Functional Outcome in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis Open
Background: Intravenous thrombolysis improves functional outcome in patients with acute stroke and frequencies of r-tPA (recombinant tissue-type plasminogen activator) treatment have been increasing over time. We aimed to assess whether fu…
View article: Dabigatran in Cerebral Sinus Vein Thrombosis and Thrombophilia
Dabigatran in Cerebral Sinus Vein Thrombosis and Thrombophilia Open
Background and Purpose: Thrombophilic gene alterations are a major risk factor for cerebral sinus vein thrombosis (CSVT). Up to 30% of all patients with cerebral sinus vein thrombosis (CSVT) are found to have thrombophilic defects such as …
View article: Value of ultrasound fusion imaging in detecting vascular cerebral white matter pathology
Value of ultrasound fusion imaging in detecting vascular cerebral white matter pathology Open
View article: Intravenous Thrombolytic Therapy for Acute Nonarteritic Central Retinal Artery Occlusion. A Review
Intravenous Thrombolytic Therapy for Acute Nonarteritic Central Retinal Artery Occlusion. A Review Open
Central retinal artery occlusion (CRAO) is a form of acute ischemic stroke. It is a critical condition that often leads to severe visual loss or blindness and can be a harbinger of further cerebrovascular events. Due to the lack of scienti…
View article: Protocol for the Exercise, Cancer and Cognition – The ECCO-Study: A Randomized Controlled Trial of Simultaneous Exercise During Neo-/Adjuvant Chemotherapy in Breast Cancer Patients and Its Effects on Neurocognition
Protocol for the Exercise, Cancer and Cognition – The ECCO-Study: A Randomized Controlled Trial of Simultaneous Exercise During Neo-/Adjuvant Chemotherapy in Breast Cancer Patients and Its Effects on Neurocognition Open
Introduction Epidemiological studies show that increased physical activity is linked to a lower risk of breast cancer and mortality. As a result, physical activity can significantly improve patients' quality of life (QOL) both during and a…
View article: Machine Learning Based Color Classification by Means of Visually Evoked Potentials
Machine Learning Based Color Classification by Means of Visually Evoked Potentials Open
Visually evoked potentials (VEPs) are widely used for diagnoses of different neurological diseases. Interestingly, there is limited research about the impact of the stimulus color onto the evoked response. Therefore, in our study we invest…
View article: Caregiver burden in patients with behavioural variant frontotemporal dementia and non-fluent variant and semantic variant primary progressive aphasia
Caregiver burden in patients with behavioural variant frontotemporal dementia and non-fluent variant and semantic variant primary progressive aphasia Open
Studies on caregiver burden in patients with frontotemporal lobar degeneration are rare, differ methodologically and show variable results. Single center longitudinal pilot study on caregiver burden and potential risk factors in patients w…
View article: Autotitrating Bilevel Positive Airway Pressure in Large Vessel Steno-Occlusive Stroke Patients With Suspected Sleep Apnea: A Multicenter Randomized Controlled Study
Autotitrating Bilevel Positive Airway Pressure in Large Vessel Steno-Occlusive Stroke Patients With Suspected Sleep Apnea: A Multicenter Randomized Controlled Study Open
Background: We hypothesized that autotitrating bilevel positive airway pressure (auto-BPAP) favorably affects short-term clinical outcomes in hyperacute ischemic stroke. Methods: In a multicenter, randomized, controlled trial patients with…
View article: C-REGS 2 - Design and methodology of a high-quality comparative effectiveness observational trial
C-REGS 2 - Design and methodology of a high-quality comparative effectiveness observational trial Open
The main aim of this study is to systematically record Cerebrolysin treatment modalities and concomitant medication, according to local standards, in patients with moderate to severe neurological deficits after acute ischemic stroke and to…
View article: Pharyngeal electrical stimulation for neurogenic dysphagia following stroke, traumatic brain injury or other causes: Main results from the PHADER cohort study
Pharyngeal electrical stimulation for neurogenic dysphagia following stroke, traumatic brain injury or other causes: Main results from the PHADER cohort study Open
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View article: Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke
Characteristics and Outcomes in Patients With COVID-19 and Acute Ischemic Stroke Open
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that severe strokes are typically associated with poor prognosis and…
View article: Enhancing and accelerating stroke treatment in Eastern European region: Methods and achievement of the ESO EAST program
Enhancing and accelerating stroke treatment in Eastern European region: Methods and achievement of the ESO EAST program Open
Introduction Despite the availability of prevention and therapies of stroke, their implementation in clinical practice, even of low-cost ones, remains poor. In 2015, the European Stroke Organisation (ESO) initiated the ESO Enhancing and Ac…
View article: Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke.
Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke. Open
Background: Results of our recently published phase III randomized clinical trial of ultrasound-enhanced thrombolysis (sonothrombolysis) using an operator-independent, high frequency ultrasound device revealed heterogeneity of patient recr…
View article: Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial
Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial Open
View article: Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke
Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke Open
Background: Results of our recently published phase III randomized clinical trial of ultrasound-enhanced thrombolysis (sonothrombolysis) using an operator-independent, high frequency ultrasound device revealed heterogeneity of patient recr…
View article: Is Functional Outcome Different in Posterior and Anterior Circulation Stroke?
Is Functional Outcome Different in Posterior and Anterior Circulation Stroke? Open
Background and Purpose— Posterior circulation stroke (PCS) account for 20% of all ischemic strokes. There is limited evidence whether functional outcome of PCS is comparable to that of anterior circulation stroke (ACS). We aimed to analyze…
View article: Pharyngeal electrical stimulation for early decannulation in tracheotomised patients with neurogenic dysphagia after stroke (PHAST-TRAC): a prospective, single-blinded, randomised trial
Pharyngeal electrical stimulation for early decannulation in tracheotomised patients with neurogenic dysphagia after stroke (PHAST-TRAC): a prospective, single-blinded, randomised trial Open
View article: Ultrasound examination of the pupil suggestive for carotid dissection
Ultrasound examination of the pupil suggestive for carotid dissection Open
A 51-year-old man presented to our emergency department with persistent right cervical pain. Neurologic examination was unremarkable, and no anisocoria was reported. Using a linear ultrasound probe, the pupillary diameters were measured at…
View article: Edoxaban zur Schlaganfallprophylaxe bei Patienten mit nicht-valvulärem Vorhofflimmern und zur Behandlung venöser Thromboembolien: ein interdisziplinäres Positionspapier
Edoxaban zur Schlaganfallprophylaxe bei Patienten mit nicht-valvulärem Vorhofflimmern und zur Behandlung venöser Thromboembolien: ein interdisziplinäres Positionspapier Open
Edoxaban is the most recent available representative of the Non-Vitamin K antagonist oral anticoagulants (NOAC). The approval was based on the largest phase III trials of NOACs for stroke prevention in patients with non-valvular atrial fib…