Milena Popova
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View article: Phytochemical Profiling and Anti-Obesogenic Potential of Scrophularia aestivalis Griseb. (Scrophulariaceae)
Phytochemical Profiling and Anti-Obesogenic Potential of Scrophularia aestivalis Griseb. (Scrophulariaceae) Open
Scrophularia aestivalis Griseb. is a Balkan endemic species whose phytochemical composition and medicinal properties have not been previously investigated. The therapeutic potential of Scrophularia species has attracted considerable attent…
View article: Green extraction of poplar type propolis: ultrasonic extraction parameters and optimization via response surface methodology
Green extraction of poplar type propolis: ultrasonic extraction parameters and optimization via response surface methodology Open
View article: Enzymes Inhibitory Properties of Compounds from Roots of <i>Mitragyna inermis</i> Willd (Rubiaceae): <i>In Vitro</i> , Molecular Docking and ADME Evaluations
Enzymes Inhibitory Properties of Compounds from Roots of <i>Mitragyna inermis</i> Willd (Rubiaceae): <i>In Vitro</i> , Molecular Docking and ADME Evaluations Open
Objective: Mitragyna inermis is important in traditional pharmacopeia and is used in treating diabetes and neurological diseases among others. This study involves inhibition of cholinesterases, α-amylase, α-glucosidase, tyrosinase and urea…
View article: Triterpenes and their Biological Activities from Propolis of Stingless Bee Tetrigonilla collina
Triterpenes and their Biological Activities from Propolis of Stingless Bee Tetrigonilla collina Open
Propolis from stingless bees has been used in traditional medicine in many countries to treat diseases. Recently, chemical constituents and biological activities of stingless bee propolis have garnered increasing scientific attention. A p…
View article: Inhibition of the MRSA Biofilm Formation and Skin Antineoplastic Activity of Ethyl Acetate Roots and Aerial Parts Extracts from Geum urbanum L.
Inhibition of the MRSA Biofilm Formation and Skin Antineoplastic Activity of Ethyl Acetate Roots and Aerial Parts Extracts from Geum urbanum L. Open
Background: The opportunistic pathogen Staphylococcus aureus causes skin and soft tissue infections that are associated with biofilm formation, and in immunocompromised patients can progress to surgical site infections, pneumonia, bacterem…
View article: The role of Indonesian stingless bee Geniotrigona thoracica Propolis extract in ameliorating obesity and modulating inflammation and autophagy process in the brain after palmitic-based high-fat diet exposure
The role of Indonesian stingless bee Geniotrigona thoracica Propolis extract in ameliorating obesity and modulating inflammation and autophagy process in the brain after palmitic-based high-fat diet exposure Open
View article: Redox-Modulating Capacity and Effect of Ethyl Acetate Roots and Aerial Parts Extracts from Geum urbanum L. on the Phenotype Inhibition of the Pseudomonas aeruginosa Las/RhI Quorum Sensing System
Redox-Modulating Capacity and Effect of Ethyl Acetate Roots and Aerial Parts Extracts from Geum urbanum L. on the Phenotype Inhibition of the Pseudomonas aeruginosa Las/RhI Quorum Sensing System Open
Pseudomonas aeruginosa is an opportunistic pathogen that causes nosocomial infections of the urinary tract, upper respiratory tract, gastrointestinal tract, central nervous system, etc. It is possible to develop bacteremia and sepsis in im…
View article: Drug-Induced Liver Toxicity
Drug-Induced Liver Toxicity Open
The liver performs many vital functions such as regulating homeostasis, bile production, storage of vitamins, and more. Another important function of the liver is to neutralize toxic substances entering the body. Substances entering the hu…
View article: Chemical Composition and Neuroprotective Properties of Indonesian Stingless Bee (Geniotrigona thoracica) Propolis Extract in an In-Vivo Model of Intracerebral Hemorrhage (ICH)
Chemical Composition and Neuroprotective Properties of Indonesian Stingless Bee (Geniotrigona thoracica) Propolis Extract in an In-Vivo Model of Intracerebral Hemorrhage (ICH) Open
Stroke is the world’s second-leading cause of death. Current treatments for cerebral edema following intracerebral hemorrhage (ICH) mainly involve hyperosmolar fluids, but this approach is often inadequate. Propolis, known for its various …
View article: Insight into the influence of natural deep eutectic solvents on the extraction of phenolic compounds from poplar type propolis: Composition and in vitro biological activity
Insight into the influence of natural deep eutectic solvents on the extraction of phenolic compounds from poplar type propolis: Composition and in vitro biological activity Open
View article: <i>Streptobacillus moniliformis</i> and IgM and IgG Immune Response in Patient with Endocarditis1
<i>Streptobacillus moniliformis</i> and IgM and IgG Immune Response in Patient with Endocarditis1 Open
We describe a case of endocarditis caused by Streptobacillus moniliformis bacteria, a known cause of rat-bite fever, in a 32-year-old woman with pet rats in Germany. The patient had a strong serologic response, with high IgM and IgG titers…
View article: Alternative Assisted Extraction Methods of Phenolic Compounds Using NaDESs
Alternative Assisted Extraction Methods of Phenolic Compounds Using NaDESs Open
A renewed understanding of eco-friendly principles is moving the industrial sector toward a shift in the utilization of less harmful solvents as a main strategy to improve manufacturing. Green analytical chemistry (GAC) has definitely pave…
View article: Propolis: Harnessing Nature’s Hidden Treasure for Sustainable Agriculture
Propolis: Harnessing Nature’s Hidden Treasure for Sustainable Agriculture Open
Recently, the search for sustainable and environmentally friendly agrochemicals from natural origin is steadily growing. Propolis, a resinous substance collected by honeybees, well known for its diverse biological activities, has attracted…
View article: The Chemical Composition of Scaptotrigona mexicana Honey and Propolis Collected in Two Locations: Similarities and Differences
The Chemical Composition of Scaptotrigona mexicana Honey and Propolis Collected in Two Locations: Similarities and Differences Open
The chemical composition of stingless bee honey and propolis depends on the plant sources they are derived from, and thus reflects the flora available in the vicinity of the hives, the preferences of the bee species, and the climate (altit…
View article: Antimicrobial, Cytotoxic, and α-Glucosidase Inhibitory Activities of Ethanol Extract and Chemical Constituents Isolated from Homotrigona apicalis Propolis—In Vitro and Molecular Docking Studies
Antimicrobial, Cytotoxic, and α-Glucosidase Inhibitory Activities of Ethanol Extract and Chemical Constituents Isolated from Homotrigona apicalis Propolis—In Vitro and Molecular Docking Studies Open
The chemical investigation of Homotrigona apicalis propolis collected in Binh Dinh province, Vietnam, led to the isolation of nine compounds, including four sesquiterpenes: spathulenol (1), 1αH,5βH-aromandendrane-4β,10α-diol (2), 1β,6α-dih…
View article: Chemical Composition of <em>Scaptotrigona mexicana</em> Honey and Propolis Collected in Two Locations: Similarities and Differences
Chemical Composition of <em>Scaptotrigona mexicana</em> Honey and Propolis Collected in Two Locations: Similarities and Differences Open
The chemical composition of stingless bee honey and propolis depends on the plant sources they are derived from, and thus reflects the flora available in the vicinity of the hives, the preference of the bee species, and the climate (altitu…
View article: Contemporary methods for the extraction and isolation of natural products
Contemporary methods for the extraction and isolation of natural products Open
View article: Chemical Profile and Antioxidant Capacity of Propolis from Tetragonula, Lepidotrigona, Lisotrigona and Homotrigona Stingless Bee Species in Vietnam
Chemical Profile and Antioxidant Capacity of Propolis from Tetragonula, Lepidotrigona, Lisotrigona and Homotrigona Stingless Bee Species in Vietnam Open
The present study aimed to analyze and compare the chemical profile and antioxidant capacity of propolis from different bee species and different regions. The chemical profiles of propolis from six stingless bee species (Tetragonula iridip…
View article: Green Extraction of Antioxidants from Natural Sources with Natural Deep Eutectic Solvents
Green Extraction of Antioxidants from Natural Sources with Natural Deep Eutectic Solvents Open
Natural deep eutectic solvents (NADES) have been developed in order to replace traditional volatile and toxic organic solvents for the extraction of biologically active substances from natural sources. Recent research has shown that …
View article: Assessing the performance of analytical methods for propolis – A collaborative trial by the international honey commission
Assessing the performance of analytical methods for propolis – A collaborative trial by the international honey commission Open
Propolis is a resinous beehive product with extraordinary bioactivity and chemical richness, linked with the botanical sources of the resin. The potential of this product keeps captivating the scientific community, conducting to continuous…
View article: Antimicrobial Triterpenoids and Ingol Diterpenes from Propolis of Semi-Arid Region of Morocco
Antimicrobial Triterpenoids and Ingol Diterpenes from Propolis of Semi-Arid Region of Morocco Open
The chemical composition and antimicrobial activity of propolis from a semi-arid region of Morocco were investigated. Fifteen compounds, including triterpenoids (1, 2, 7–12), macrocyclic diterpenes of ingol type (3–6) and aromatic derivati…
View article: Polyphenols and Minor Constituents in Honey from North Macedonia and Bulgaria
Polyphenols and Minor Constituents in Honey from North Macedonia and Bulgaria Open
Honey is a highly concentrated sugar solution that is a rich source of many bioactive compounds including numerous minor constituents. Among them, polyphenols such as flavonoids and phenolic acids are the most important classes of ph…
View article: Natural Deep Eutectic Extracts of Propolis, <i>Sideritis scardica</i>, and <i>Plantago major</i> Reveal Potential Antiageing Activity during Yeast Chronological Lifespan
Natural Deep Eutectic Extracts of Propolis, <i>Sideritis scardica</i>, and <i>Plantago major</i> Reveal Potential Antiageing Activity during Yeast Chronological Lifespan Open
Nowadays, the environmentally friendly approach to everyday life routines including body supplementation with pharma‐, nutraceuticals and dietary supplements gains popularity. This trend is implemented in pharmaceutical as well as cosmetic…
View article: In Vitro Antineoplastic and Antiviral Activity and In Vivo Toxicity of Geum urbanum L. Extracts
In Vitro Antineoplastic and Antiviral Activity and In Vivo Toxicity of Geum urbanum L. Extracts Open
This study evaluated the in vitro antineoplastic and antiviral potential and in vivo toxicity of twelve extracts with different polarity obtained from the herbaceous perennial plant Geum urbanum L. (Rosaceae). In vitro cytotoxicity was det…
View article: Mangifera indica as propolis source: what exactly do bees collect?
Mangifera indica as propolis source: what exactly do bees collect? Open
View article: Redox-modulation, Suppression of “Oncogenic” Superoxide and Induction of Apoptosis in Burkitt’s Lymphoma Cells Using Geum urbanum L. Extracts
Redox-modulation, Suppression of “Oncogenic” Superoxide and Induction of Apoptosis in Burkitt’s Lymphoma Cells Using Geum urbanum L. Extracts Open
Burkitt’s lymphoma is a highly aggressive type of non-Hodgkin’s lymphoma, linked to the Epstein-Barr virus, which induces oxidative stress and DNA damage in the infected cells. We investigated the cytotoxicity and redox-modulating ability …
View article: In Vitro Multiplication and NMR Fingerprinting of Rare Veronica caucasica M. Bieb
In Vitro Multiplication and NMR Fingerprinting of Rare Veronica caucasica M. Bieb Open
Micropropagation of rare Veronica caucasica M. Bieb. was achieved by successful in vitro cultivation of mono-nodal segments on MS medium supplemented with 1.0 mg L–1 6-benzylaminopurine (BA) and then transferring the regenerated plants on …
View article: A Preliminary Study of Chemical Profiles of Honey, Cerumen, and Propolis of the African Stingless Bee Meliponula ferruginea
A Preliminary Study of Chemical Profiles of Honey, Cerumen, and Propolis of the African Stingless Bee Meliponula ferruginea Open
Recently, the honey and propolis of stingless bees have been attracting growing attention because of their health-promoting properties. However, studies on these products of African Meliponini are still very scarce. In this preliminary stu…
View article: <i>In vivo</i> assessment of acute and subacute toxicity of ethyl acetate extract from aerial parts of <i>Geum urbanum</i> L
<i>In vivo</i> assessment of acute and subacute toxicity of ethyl acetate extract from aerial parts of <i>Geum urbanum</i> L Open
Geum urbanum L. is a medicinal plant used from ancient time against gastro-intestinal disorders, bleeding and inflammation of mucous membranes, gums (gingivitis), etc. In our previous works, we demonstrated the antibacterial and antioxidan…
View article: Extracts of medicinal plants with natural deep eutectic solvents: enhanced antimicrobial activity and low genotoxicity
Extracts of medicinal plants with natural deep eutectic solvents: enhanced antimicrobial activity and low genotoxicity Open
Natural deep eutectic solvents (NADES) are a new alternative to toxic organic solvents. Their constituents are primary metabolites, non-toxic, biocompatible and sustainable. In this study four selected NADES were applied for the extraction…