Miloš Petković
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View article: Chitosan–Hydrazone-Modified Calcium Phosphate Scaffolds: Fabrication, Characterization, and Drug Delivery Potential
Chitosan–Hydrazone-Modified Calcium Phosphate Scaffolds: Fabrication, Characterization, and Drug Delivery Potential Open
Background/Objectives: Recent advancements in biomaterials aimed at closely mimicking natural biological tissues hold great promise for hard tissue regeneration and controlled drug release due to their superior physical, chemical, and biol…
View article: Molecular Docking, Machine Learning-Guided Design, Synthesis, and Biological Evaluation of Novel Multitarget HDAC/ROCK Inhibitors
Molecular Docking, Machine Learning-Guided Design, Synthesis, and Biological Evaluation of Novel Multitarget HDAC/ROCK Inhibitors Open
Histone deacetylases (HDACs) and Rho-associated coiled-coil containing protein kinases (ROCKs) are critical regulators of tumor development, progression and immunomodulation, particularly in aggressive cancers such as triple negative breas…
View article: Pharmacological manipulation of liver fibrosis progression using novel <scp>HDAC</scp>6 inhibitors
Pharmacological manipulation of liver fibrosis progression using novel <span>HDAC</span>6 inhibitors Open
Chronic liver injury characterized by unresolved hepatitis leads to fibrosis, potentially progressing to cirrhosis and hepatocellular carcinoma. Effective treatments for halting or reversing liver fibrosis are currently lacking. This study…
View article: Valorisation of Sunflower Crop Residue as a Potentially New Source of Bioactive Compounds
Valorisation of Sunflower Crop Residue as a Potentially New Source of Bioactive Compounds Open
Reducing agricultural waste through reuse has become one of the most important strategies to minimise impact on the environment—an emerging global issue. Sunflower ranks fourth in the world in the production of vegetable oilseeds and there…
View article: Intravenous Nanoemulsions Loaded with Phospholipid Complex of a Novel Pyrazoloquinolinone Ligand for Enhanced Brain Delivery
Intravenous Nanoemulsions Loaded with Phospholipid Complex of a Novel Pyrazoloquinolinone Ligand for Enhanced Brain Delivery Open
Background/Objectives: The novel pyrazoloquinolinone ligand CW-02-79 shows a unique profile of selective binding to σ2 receptors, but its poor solubility in both water and lipids makes its research and development a burdensome task. We aim…
View article: Polyphenolic composition and antioxidant capacity in the branches and leaves of selected Prunus and Pyrus species
Polyphenolic composition and antioxidant capacity in the branches and leaves of selected Prunus and Pyrus species Open
Plants of the genus Prunus and Pyrus have been valued and used for centuries due to their rich nutritional and therapeutic properties. The fruit itself is primarily consumed, while other parts of the plants are often overlooked despite the…
View article: Development of Novel ROCK Inhibitors via 3D-QSAR and Molecular Docking Studies: A Framework for Multi-Target Drug Design
Development of Novel ROCK Inhibitors via 3D-QSAR and Molecular Docking Studies: A Framework for Multi-Target Drug Design Open
Background/Objectives: Alterations in the actin cytoskeleton correlates to tumor progression and affect critical cellular processes such as adhesion, migration and invasion. Rho-associated coiled-coil-containing protein kinases (ROCK1 and …
View article: Functionalization of silk with actinomycins from Streptomyces anulatus BV365 for biomedical applications
Functionalization of silk with actinomycins from Streptomyces anulatus BV365 for biomedical applications Open
Silk, traditionally acclaimed as the “queen of fiber,” has been widely used thanks to its brilliant performance such as gentleness, smoothness and comfortableness. Owing to its mechanical characteristics and biocompatibility silk has a def…
View article: Synthesis and in vitro study of redox properties of pyrrole and halogenated pyrrole derivatives
Synthesis and in vitro study of redox properties of pyrrole and halogenated pyrrole derivatives Open
The redox balance plays a crucial role in maintaining biological processes under normal conditions. Antioxidants inhibit and reduce harmful oxidation processes, while pro-oxidants can act as anti-cancer agents by promoting ROS-mediated cel…
View article: Front Cover Picture: Three Component Cascade Processes Involving Palladium Catalyzed Transformations/Dipolar Cycloadditions for the Synthesis of Angular Heterotriquinane Derivatives (Adv. Synth. Catal. 17/2024)
Front Cover Picture: Three Component Cascade Processes Involving Palladium Catalyzed Transformations/Dipolar Cycloadditions for the Synthesis of Angular Heterotriquinane Derivatives (Adv. Synth. Catal. 17/2024) Open
The front cover picture was generated by artificial intelligence around our description of the landscape we intended to create. The cascade waterfall symbolizes the cascade transformation depicted schematically on the image. The starting o…
View article: Cytotoxic prenylated phenols of false indigo-bush ( <i>Amorpha fruticosa</i> L.)
Cytotoxic prenylated phenols of false indigo-bush ( <i>Amorpha fruticosa</i> L.) Open
This study employed the MTT assay to assess the cytotoxicity of one flavan and two stilbene derivatives isolated from the false indigo-bush (Amorpha fruticosa L.) fruits: 5,7-dihydroxy-8-geranylflavanone (1), 2-carboxy-3,5-di…
View article: CCDC 2233308: Experimental Crystal Structure Determination
CCDC 2233308: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: In vitro study of redox properties of azolyl-lactones in human serum
In vitro study of redox properties of azolyl-lactones in human serum Open
Disruption of the redox balance in the body causes oxidative stress that can initiate many diseases. While antioxidants reduce the level of oxidizing compounds in the medium, prooxidants promote the opposite process and have been used in t…
View article: The odyssey of strategic investing in artificial intelligence (AI) startups
The odyssey of strategic investing in artificial intelligence (AI) startups Open
This paper investigates the dynamics and challenges faced by strategic investors in the context of Artificial Intelligence (AI) startups.As the landscape of financial markets evolves, strategic investments in AI startups have gained consid…
View article: Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation
Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation Open
Isoform-selective histone deacetylase (HDAC) inhibition is promoted as a rational strategy to develop safer anti-cancer drugs compared to non-selective HDAC inhibitors. Despite this presumed benefit, considerably more non-selective HDAC in…
View article: Microwave Assisted Esterification of Aryl/Alkyl Acids Catalyzed by N-Fluorobenzenesulfonimide
Microwave Assisted Esterification of Aryl/Alkyl Acids Catalyzed by N-Fluorobenzenesulfonimide Open
The susceptibility of the carbonyl group towards nucleophilic attack affords the construction of various organic compounds. Thus, investigations of carbonyl activation applying greener methodologies are highly important. In the present wor…
View article: Discovery of 1-benzhydryl piperazine-based HDAC inhibitors with anti-cancer and anti-metastatic properties against human breast cancer: synthesis, molecular modeling, in vitro and in vivo biological evaluation
Discovery of 1-benzhydryl piperazine-based HDAC inhibitors with anti-cancer and anti-metastatic properties against human breast cancer: synthesis, molecular modeling, in vitro and in vivo biological evaluation Open
Isoform-selective histone deacetylase (HDAC) inhibition is promoted as a rational strategy to develop safer anti-cancer drugs compared to non-selective HDAC inhibitors. Despite this presumed benefit, considerably more non-selective HDAC in…
View article: Hibridni tarifni model putarine - analiza prihvatljivosti
Hibridni tarifni model putarine - analiza prihvatljivosti Open
Konferencija sa međunarodnim učešćem TESI : zbornik radova / XIII konferencija o tehnikama saobraćajnog inženjerstva, Vrnjačka Banja, 13-14. oktobar 2022. ; organizator Univerzitet u Beogradu, Saobraćajni fakultet, Modul za saobraćajno inž…
View article: Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117
Synthesis, Anticancer Potential and Comprehensive Toxicity Studies of Novel Brominated Derivatives of Bacterial Biopigment Prodigiosin from Serratia marcescens ATCC 27117 Open
Prodigiosins (prodiginines) are a class of bacterial secondary metabolites with remarkable biological activities and color. In this study, optimized production, purification, and characterization of prodigiosin (PG) from easily accessible …
View article: Discovery of 1-benzhydryl piperazine-based HDAC inhibitors with anticancer and antimetastatic properties against human breast cancer: synthesis, molecular modeling, in vitro and in vivo biological evaluation
Discovery of 1-benzhydryl piperazine-based HDAC inhibitors with anticancer and antimetastatic properties against human breast cancer: synthesis, molecular modeling, in vitro and in vivo biological evaluation Open
Selective histone deacetylase 6 (HDAC6) inhibition is promoted as a rational strategy to develop safer anticancer drugs compared to nonselective HDAC inhibitors. Nevertheless, considerably more nonselective HDAC inhibitors have been underg…
View article: Fragment‐type 4‐azolylcoumarin derivatives with anticancer properties
Fragment‐type 4‐azolylcoumarin derivatives with anticancer properties Open
Several coumarin derivatives with a directly attached azole substituent at C‐4 were synthesized and biologically studied for their anticancer properties. The cell lines used for this investigation (HeLa, K‐562, MDA‐MB‐53, and MCF‐7) demons…
View article: Synthesis and Laccase-Mediated Oxidation of New Condensed 1,4-Dihydropyridine Derivatives
Synthesis and Laccase-Mediated Oxidation of New Condensed 1,4-Dihydropyridine Derivatives Open
We describe herein the synthesis and laccase mediated oxidation of six novel 1,4-dihydropyridine (DHP)-based hexahydroquinolines (DHP1-DHP3) and decahydroacridines (DHP4-DHP6). We employed different laccase enzymes with varying redox poten…
View article: Characterization of Biomolecules with Antibiotic Activity from Endophytic Fungi Phomopsis Species
Characterization of Biomolecules with Antibiotic Activity from Endophytic Fungi Phomopsis Species Open
Recently, growing interest is devoted to investigation of bioactive secondary metabolites of endophytic fungi. Thus, as an extension to our previous achievements related to antimicrobial potential of endophytic fungi, Phomopsis species iso…
View article: Stereocontrolled Synthesis of Highly Substituted <i>trans</i> α,β‐Unsaturated Ketones with Potent Anticancer Properties from Glycals
Stereocontrolled Synthesis of Highly Substituted <i>trans</i> α,β‐Unsaturated Ketones with Potent Anticancer Properties from Glycals Open
A novel synthetic route for highly substituted conjugated ketones has been developed utilizing glycals as starting materials. The two‐step process combined the Heck reaction/Lewis acid promoted ring opening to afford the products in 33–80 …
View article: From mycelium to spores: A whole circle of biological potency of mosaic puffball
From mycelium to spores: A whole circle of biological potency of mosaic puffball Open
Methanol extracts of mosaic puffball (Handkea utriformis, Bovistella utriformis, Lycoperdon utriforme, Calvatia utriformis - current name is a subject of debate), from three different stages - mycelium (HUMIC), immature (HUI) and mature fr…
View article: The impact of puffball autolysis on selected chemical and biological properties: Puffball extracts as potential ingredients of skin-care products
The impact of puffball autolysis on selected chemical and biological properties: Puffball extracts as potential ingredients of skin-care products Open
Puffballs are fungi that produce globose fruiting bodies that undergo autolysis, transforming their insides into a spore bearing, powdery mass. Mature fruiting bodies are traditionally used to treat open skin wounds. In this study, methano…
View article: Synthesis, structural characterization and antimicrobial activity of silver(I) complexes with 1-benzyl-1H-tetrazoles
Synthesis, structural characterization and antimicrobial activity of silver(I) complexes with 1-benzyl-1H-tetrazoles Open
View article: Highly selective anthraquinone-chalcone hybrids as potential antileukemia agents
Highly selective anthraquinone-chalcone hybrids as potential antileukemia agents Open
View article: CCDC 1851085: Experimental Crystal Structure Determination
CCDC 1851085: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1851086: Experimental Crystal Structure Determination
CCDC 1851086: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …