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View article: Momordica charantia L. (Cucurbitaceae) Leaf Extract from Phytochemical Characterization and Toxicity Evaluation to Modulation of Pro-Inflammatory Cytokines and MAPK/NFκB Pathways
Momordica charantia L. (Cucurbitaceae) Leaf Extract from Phytochemical Characterization and Toxicity Evaluation to Modulation of Pro-Inflammatory Cytokines and MAPK/NFκB Pathways Open
Momordica charantia L. (Cucurbitaceae) has been widely recognized for its pharmacological potential, although studies on its leaves remain scarce. In this study, the hydroethanolic leaf extract (MCHLE) was chemically characterized by LC–MS…
View article: NURSING CONTRIBUTIONS TO CARE MANAGEMENT IN PRIMARY HEALTH CARE: A LITERATURE REVIEW
NURSING CONTRIBUTIONS TO CARE MANAGEMENT IN PRIMARY HEALTH CARE: A LITERATURE REVIEW Open
Introduction: Primary Health Care (PHC), mainly structured through the Family Health Strategy (FHS), is the main entry point to the Unified Health System (SUS). In this context, nursing plays a central role both in care delivery and in car…
View article: A preliminary study about Coenzyme Q10 and Zinc supplementation in children with Down Syndrome
A preliminary study about Coenzyme Q10 and Zinc supplementation in children with Down Syndrome Open
Down syndrome (DS) is marked by oxidative stress due to an imbalance between reactive oxygen species (ROS) and antioxidant enzymes. Antioxidant compounds like coenzyme Q10 (CoQ10) and zinc (Zn) may mitigate cellular imbalances induced by e…
View article: Phytochemical Profiling of Processed Açaí Pulp (Euterpe oleracea) Through Mass Spectrometry and Its Protective Effects Against Oxidative Stress in Cardiomyocytes and Rats
Phytochemical Profiling of Processed Açaí Pulp (Euterpe oleracea) Through Mass Spectrometry and Its Protective Effects Against Oxidative Stress in Cardiomyocytes and Rats Open
The antioxidant capacity and modulation of oxidative stress by industrially processed açaí pulp extract from the Amazon (APEA) and its major anthocyanins, cyanidin 3-glucoside (C3G) and cyanidin-3-O-rutinoside (C3R), were evaluated as pote…
View article: Dissatisfaction with body image and weight gain in middle-aged women: A cross sectional study
Dissatisfaction with body image and weight gain in middle-aged women: A cross sectional study Open
Objectives To investigate the relationship between weight gain and body image perception in in middle-aged women. Methods Cross-sectional study with 453 women. Body image was assessed using the Stunkard scale, in which women were classifie…
View article: Pseudobombax parvifolium Hydroalcoholic Bark Extract: Chemical Characterisation and Cytotoxic, Mutagenic, and Preclinical Aspects Associated with a Protective Effect on Oxidative Stress
Pseudobombax parvifolium Hydroalcoholic Bark Extract: Chemical Characterisation and Cytotoxic, Mutagenic, and Preclinical Aspects Associated with a Protective Effect on Oxidative Stress Open
Plants have long been used in traditional medicine to treat illnesses. Nevertheless, their chemical diversity requires studies to establish the extract dosage and its safe use. Pseudobombax parvifolium, an endemic species of the Brazilian …
View article: Antioxidant and Lipid-Lowering Effects of Buriti Oil (Mauritia flexuosa L.) Administered to Iron-Overloaded Rats
Antioxidant and Lipid-Lowering Effects of Buriti Oil (Mauritia flexuosa L.) Administered to Iron-Overloaded Rats Open
The indiscriminate use of oral ferrous sulfate (FeSO4) doses induces significant oxidative damage to health. However, carotene-rich foods such as buriti oil can help the endogenous antioxidant defense and still maintain other body function…
View article: In Vitro Antithrombotic, Antitumor and Antiangiogenic Activities of Green Tea Polyphenols and Its Main Constituent Epigallocatechin-3-gallate
In Vitro Antithrombotic, Antitumor and Antiangiogenic Activities of Green Tea Polyphenols and Its Main Constituent Epigallocatechin-3-gallate Open
The balance between embolic risk and bleeding represents a clinical challenge in cancer patient treatment, encouraging studies on adjuvant oncologic treatments. Thereby, this study evaluated the in vitro effect of green tea extract (GTE) a…
View article: The effect of lipoic acid and physical exercise on superoxide dismutase activity and postmenopausal symptoms
The effect of lipoic acid and physical exercise on superoxide dismutase activity and postmenopausal symptoms Open
The present study aimed to evaluate the effect of lipoic acid supplementation and physical exercise on the activity of the enzyme Superoxide Dismutase (SOD) and on signs and symptoms of post-menopause.Thirty-three postmenopausal participan…
View article: Mass Spectrometric Identification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflammatory Response
Mass Spectrometric Identification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflammatory Response Open
Licania rigida Benth has been evaluated as an alternative drug to treat diseases associated with inflammatory processes. This study evaluated the anti-inflammatory effects of aqueous and hydroalcoholic leaf extracts of L. rigida with infla…
View article: Antioxidant Effect of Coenzyme Q10 in the Prevention of Oxidative Stress in Arsenic-Treated CHO-K1 Cells and Possible Participation of Zinc as a Pro-Oxidant Agent
Antioxidant Effect of Coenzyme Q10 in the Prevention of Oxidative Stress in Arsenic-Treated CHO-K1 Cells and Possible Participation of Zinc as a Pro-Oxidant Agent Open
Oxidative stress is an imbalance between levels of reactive oxygen species (ROS) and antioxidant enzymes. Compounds with antioxidant properties, such as coenzyme Q10 (CoQ10), can reduce cellular imbalance caused by an increase in ROS. CoQ1…
View article: The First Optimization Process from Cultivation to Flavonoid-Rich Extract from Moringa oleifera Lam. Leaves in Brazil
The First Optimization Process from Cultivation to Flavonoid-Rich Extract from Moringa oleifera Lam. Leaves in Brazil Open
Flavonoids are significant antioxidant and anti-inflammatory agents and have multiple potential health applications. Moringa oleifera is globally recognized for its nutritional and pharmacological properties, correlated to the high flavono…
View article: Chemical Characterization of Flowers and Leaf Extracts Obtained from Turnera subulata and Their Immunomodulatory Effect on LPS-Activated RAW 264.7 Macrophages
Chemical Characterization of Flowers and Leaf Extracts Obtained from Turnera subulata and Their Immunomodulatory Effect on LPS-Activated RAW 264.7 Macrophages Open
The anti-inflammatory properties of Turnera subulata have been evaluated as an alternative drug approach to treating several inflammatory processes. Accordingly, in this study, aqueous and hydroalcoholic extracts of T. subulata flowers and…
View article: Association between MTHFR C677T and A1298C gene polymorphisms and maternal risk for Down syndrome: A protocol for systematic review and/or meta-analysis.
Association between MTHFR C677T and A1298C gene polymorphisms and maternal risk for Down syndrome: A protocol for systematic review and/or meta-analysis. Open
This systematic review and meta-analysis protocol has been registered on the Prospective Registry of International Systematic Review and Meta-analyses: CRD42021269338.
View article: Identification of NID1 as a novel candidate susceptibility gene for familial non-medullary thyroid carcinoma using whole-exome sequencing
Identification of NID1 as a novel candidate susceptibility gene for familial non-medullary thyroid carcinoma using whole-exome sequencing Open
The genetics underlying non-syndromic familial non-medullary thyroid carcinoma (FNMTC) is still poorly understood. To identify susceptibility genes for FNMTC, we performed whole-exome sequencing (WES) in a Brazilian family affected by papi…
View article: INSTRUMENT FOR ASSESSMENT MEDICATION TREATMENT ADHE-RENCE AMONG PEOPLE WITH DIABETES
INSTRUMENT FOR ASSESSMENT MEDICATION TREATMENT ADHE-RENCE AMONG PEOPLE WITH DIABETES Open
A adesão ao tratamento medicamentoso é fundamental para o sucesso da terapia. Objetivou-se desenvolver um instrumento de avaliação da Adesão Medicamentosa no Diabetes Melitus (AMDM) e avaliar suas propriedades psicométricas. Trata-se de um…
View article: Licania rigida Benth leaf extracts: Assessment of toxicity and potential anticoagulant effect
Licania rigida Benth leaf extracts: Assessment of toxicity and potential anticoagulant effect Open
The present study evaluated the in vitro and in vivo potential toxicological effects, and the in vitro anticoagulant action of Licania rigida Benth crude leaf extract (CELR) and ethyl acetate fraction (AFLR). The in vitro toxicity was asse…
View article: IRF6 polymorphisms in Brazilian patients with non-syndromic cleft lip with or without palate
IRF6 polymorphisms in Brazilian patients with non-syndromic cleft lip with or without palate Open
Introduction: Non-syndromic orofacial clefts have a complex etiology due to the contribution from both genetic and environmental risk factors, as well as the interaction between them. Among the more than 15 susceptibility loci for non-synd…
View article: Bioelectrical Impedance Vector Analysis and Phase Angle on Different Oral Zinc Supplementation in Eutrophic Children: Randomized Triple-Blind Study
Bioelectrical Impedance Vector Analysis and Phase Angle on Different Oral Zinc Supplementation in Eutrophic Children: Randomized Triple-Blind Study Open
The parameters derived from bioelectrical impedance, phase angle (PA) and bioelectrical impedance vector analysis (BIVA) have been associated with cell membrane integrity and body cell mass. Zinc is a micronutrient that exerts important st…
View article: Physicochemical Characterization and Phenolic Profile of Oiti Fruits (Licania tomentosa Benth Fristch)
Physicochemical Characterization and Phenolic Profile of Oiti Fruits (Licania tomentosa Benth Fristch) Open
Oiti (Licania tomentosa Benth Friscth) belongs to the Chrysobalanaceae family; it’s native to the Brazilian tropical forest (Caatinga). Although existing studies have demonstrated the antioxidant, anticholinesterase and antibacterial effec…
View article: The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus
The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus Open
The LRP5 4037C>T may represent a candidate for T1DM susceptibility, as well as poor glycemic control.
View article: Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus
Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus Open
The aim of the present study was to investigate the bone mineral density (BMD) of patients with type 1 Diabetes mellitus (T1DM). We also assessed the association between osteoprotegerin (OPG) genetic polymorphisms and BMD. Genotyping was p…
View article: The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus
The low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism: candidate for susceptibility to type 1 diabetes mellitus Open
Objective: The present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population. Subjects and…
View article: Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus
Relationship between glycemic control and OPG gene polymorphisms with lower bone mineral density in patients with type 1 Diabetes mellitus Open
The aim of the present study was to investigate the bone mineral density (BMD) of patients with type 1 Diabetes mellitus (T1DM). We also assessed the association between osteoprotegerin (OPG) genetic polymorphisms and BMD. Genotyping was p…
View article: Does body image perception relate to quality of life in middle-aged women?
Does body image perception relate to quality of life in middle-aged women? Open
Women who reported being dissatisfied with their body image due to having low weight or overweight had worse quality of life in comparison to those who were satisfied (with their body weight).