Mimi L. Phan
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View article: Daily high doses of atorvastatin alter neuronal morphology in a juvenile songbird model
Daily high doses of atorvastatin alter neuronal morphology in a juvenile songbird model Open
Statins are highly effective and widely prescribed cholesterol lowering drugs. However, statins cross the blood-brain barrier and decrease neural cholesterol in animal models, raising concern that long-term statin use may impact cholestero…
View article: Chemogenetic activation of corticotropin-releasing factor-expressing neurons in the anterior bed nucleus of the stria terminalis reduces effortful motivation behaviors
Chemogenetic activation of corticotropin-releasing factor-expressing neurons in the anterior bed nucleus of the stria terminalis reduces effortful motivation behaviors Open
Corticotropin-releasing factor (CRF) in the anterior bed nucleus of the stria terminalis (aBNST) is associated with chronic stress and avoidance behavior. However, CRF+ BNST neurons project to reward- and motivation-related brain regions, …
View article: Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis
Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis Open
The bed nucleus of the stria terminalis (BNST) is a forebrain region highly responsive to stress that expresses corticotropin-releasing hormone (CRH) and is implicated in mood disorders, such as anxiety. However, the exact mechanism by whi…
View article: Influence of early-life nutritional stress on songbird memory formation
Influence of early-life nutritional stress on songbird memory formation Open
In birds, vocal learning enables the production of sexually selected complex songs, dialects and song copy matching. But stressful conditions during development have been shown to affect song production and complexity, mediated by changes …
View article: Observations of Toddlers’ Sensory-based Exploratory Behaviors with a Novel Food
Observations of Toddlers’ Sensory-based Exploratory Behaviors with a Novel Food Open
Background: Food neophobia hinders the acceptance of healthy food in young children, and may be overcome by repeated food exposure. The prevalent literature states that children exhibit 5 sensory-based exploratory behaviors (SBEBs): smelli…
View article: Supporting data from Influence of early-life nutritional stress on songbird memory formation
Supporting data from Influence of early-life nutritional stress on songbird memory formation Open
In birds, vocal learning enables the production of sexually selected complex songs, dialects and song copy matching. But stressful conditions during development have been shown to affect song production and complexity, mediated by changes …
View article: The effects of long-term atorvastatin use on the cytoarchitecture of new and older neurons of sensorimotor nucleus HVC in a juvenile songbird model
The effects of long-term atorvastatin use on the cytoarchitecture of new and older neurons of sensorimotor nucleus HVC in a juvenile songbird model Open
Statins are widely prescribed and highly efficacious cholesterol lowering drugs. Due to their success in lowering serum cholesterol in adults, the Food and Drug Administration approved four statins, including atorvastatin, for pediatric po…
View article: HDAC3 Inhibitor RGFP966 Modulates Neuronal Memory for Vocal Communication Signals in a Songbird Model
HDAC3 Inhibitor RGFP966 Modulates Neuronal Memory for Vocal Communication Signals in a Songbird Model Open
Epigenetic mechanisms that modify chromatin conformation have recently been under investigation for their contributions to learning and the formation of memory. For example, the role of enzymes involved in histone acetylation are studied i…
View article: Sensory Cortical Plasticity Participates in the Epigenetic Regulation of Robust Memory Formation
Sensory Cortical Plasticity Participates in the Epigenetic Regulation of Robust Memory Formation Open
Neuroplasticity remodels sensory cortex across the lifespan. A function of adult sensory cortical plasticity may be capturing available information during perception for memory formation. The degree of experience-dependent remodeling in se…