Min Lin
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View article: Multicellular force coordination constructs microchannel networks for barrier-free metastasis across extracellular matrix
Multicellular force coordination constructs microchannel networks for barrier-free metastasis across extracellular matrix Open
The extracellular matrix (ECM) acts as a primary physical barrier to cancer metastasis. While individual cancer cells can remodel ECM to create microchannel-like paths of least resistance, this cell-centric view overlooks the coordinated d…
View article: Unveiling the prognostic power of FIB-4 index: a new frontier in heart failure mortality
Unveiling the prognostic power of FIB-4 index: a new frontier in heart failure mortality Open
FIB-4 is a reliable predictor of all-cause deaths in HF patients.
View article: Sum It Up for Me: A Novel Workshop in the Synthesis of Comprehensive Summary Statements for Pediatric Residents
Sum It Up for Me: A Novel Workshop in the Synthesis of Comprehensive Summary Statements for Pediatric Residents Open
Our novel workshop demonstrated improvement in confidence in developing and assessing summary statements, improved knowledge of recommended components of a summary statement, and resulted in a statistically significant improvement in the q…
View article: MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis Open
Cancer metastasis is governed by physical cues at the cell‐matrix interface, with matrix stiffness, ligand density, and topography established as key determinants. Here, a fourth critical factor in cancer metastasis, the architecture of th…
View article: Traction-regulated persistence governs durotaxis across cell types
Traction-regulated persistence governs durotaxis across cell types Open
Cell migration toward stiffer or softer environments (durotaxis) underlies processes from development to cancer metastasis, yet the underlying mechanism and its universality remain unclear. To resolve this, we investigated how traction for…
View article: Computational methodology and molecular dynamics analysis of andrographolide bioactivity against Cutibacterium acnes
Computational methodology and molecular dynamics analysis of andrographolide bioactivity against Cutibacterium acnes Open
Cutibacterium acnes (formerly known as Propionibacterium acnes ) is a Gram-positive anaerobic bacterium that is frequently found in sebaceous glands and human skin hair follicles. Although it is a normal component of the skin microbiota, a…
View article: Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding
Synthesis of Differentially Halogenated Lissoclimide Analogues To Probe Ribosome E-Site Binding Open
Halogenated natural products from marine sources often demonstrate potent activity against microorganisms and cancer cell lines. During the last three decades, the lissoclimide class of chlorinated labdane diterpenoids has been characteriz…
View article: Carbon-resistant bifunctional catalyst composed of LaFeO3 enhanced Ni-CaO for integrated CO2 capture and conversion
Carbon-resistant bifunctional catalyst composed of LaFeO3 enhanced Ni-CaO for integrated CO2 capture and conversion Open
Coupled calcium cycling and dry reforming of methane (CaL-DRM) process has garnered significant attention in recent years as a promising technique for the CO2 capture and in-situ conversion. However, traditional Ni-CaO catalysts with subst…
View article: Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer's Disease
Roles of TREM2 in the Pathological Mechanism and the Therapeutic Strategies of Alzheimer's Disease Open
Alzheimer's disease (AD) is an age-related degenerative disease, which is characteristic by the deposition of senile plaques (SP) outside the cells, the neurofibrillary tangles (NFTs) inside the neurons, and the loss of synapse and neurons…
View article: A single-cell transcriptomic landscape of cadmium-hindered brain development in mice
A single-cell transcriptomic landscape of cadmium-hindered brain development in mice Open
The effects of neurotoxicant cadmium (Cd) exposure on brain development have not been well elucidated. To investigate this, we have herein subjected pregnant mice to low-dose Cd throughout gestation. Using single-cell RNA sequencing (scRNA…
View article: A novel prognostic signature based on cancer stemness and metabolism-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma
A novel prognostic signature based on cancer stemness and metabolism-related genes for cervical squamous cell carcinoma and endocervical adenocarcinoma Open
The current investigation indicated that a 3-gene signature based on stemness-related metabolic and 4 hub genes with differential expression between high and low-risk score subgroups may serve as valuable prognostic markers and potential t…
View article: [Integrin and N-cadherin Co-Regulate the Polarity of Mesenchymal Stem Cells via Mechanobiological Mechanisms].
[Integrin and N-cadherin Co-Regulate the Polarity of Mesenchymal Stem Cells via Mechanobiological Mechanisms]. Open
Integrin and N-cadherin co-regulate the polarity distribution of cell proteins and N-cadherin can play an important role in the polarity regulation of stem cells through local inhibition of integrin.
View article: Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery
Advances in modeling cellular mechanical perceptions and responses via the membrane-cytoskeleton-nucleus machinery Open
Mechanical models offer a quantitative framework for understanding scientific problems, predicting novel phenomena, and guiding experimental designs. Over the past few decades, the emerging field of cellular mechanobiology has greatly bene…
View article: Programmable and Reversible Integrin‐Mediated Cell Adhesion Reveals Hysteresis in Actin Kinetics that Alters Subsequent Mechanotransduction (Adv. Sci. 35/2023)
Programmable and Reversible Integrin‐Mediated Cell Adhesion Reveals Hysteresis in Actin Kinetics that Alters Subsequent Mechanotransduction (Adv. Sci. 35/2023) Open
Mechanotransduction Article number 2302421 reports that cyclical adhesion can alter stem cell perception of extracellular microenvironment stiffness and thereby controls their mechanosensing and fate commitment. Min Lin and co‐workers demo…
View article: Programmable and Reversible Integrin‐Mediated Cell Adhesion Reveals Hysteresis in Actin Kinetics that Alters Subsequent Mechanotransduction
Programmable and Reversible Integrin‐Mediated Cell Adhesion Reveals Hysteresis in Actin Kinetics that Alters Subsequent Mechanotransduction Open
Dynamically evolving adhesions between cells and extracellular matrix (ECM) transmit time‐varying signals that control cytoskeletal dynamics and cell fate. Dynamic cell adhesion and ECM stiffness regulate cellular mechanosensing cooperativ…
View article: DFT computational and spectroscopic studies on andrographolide from different solvent effect
DFT computational and spectroscopic studies on andrographolide from different solvent effect Open
Andrographolide was used to traditional medical treatment owing to widely pharmacological activity. Hence, the demand is increasing in drug formulations from this herb as a significant medical ingredient recently and its extraction was als…
View article: Characteristics Analysis of Plasticized Polyvinyl Chloride Gel-Based Microlens at Different Temperatures
Characteristics Analysis of Plasticized Polyvinyl Chloride Gel-Based Microlens at Different Temperatures Open
Temperature plays a crucial role in the preparation of polyvinyl chloride (PVC) gels for optical applications. Incorrect temperature selection can lead to various issues such as poor surface roughness, inadequate light transmission, and in…
View article: T Cell engineering for cancer immunotherapy by manipulating mechanosensitive force-bearing receptors
T Cell engineering for cancer immunotherapy by manipulating mechanosensitive force-bearing receptors Open
T cell immune responses are critical for in both physiological and pathological processes. While biochemical cues are important, mechanical cues arising from the microenvironment have also been found to act a significant role in regulating…
View article: Self‐assembly Promoted Crystallization of Diblock Copolypeptoids in Solution<sup>†</sup>
Self‐assembly Promoted Crystallization of Diblock Copolypeptoids in Solution<sup>†</sup> Open
Comprehensive Summary Great efforts have been lately devoted to fabricating well‐defined nanostructures using crystallization‐driven self‐assembly (CDSA) strategy. The influence of self‐assembly on crystallization is also of great interest…
View article: Fabrication of Antifouling/Antimicrobial Polysulfonium‐Coated Surface Against Biofilms and Water Bacterial Contamination
Fabrication of Antifouling/Antimicrobial Polysulfonium‐Coated Surface Against Biofilms and Water Bacterial Contamination Open
Bacterial attachment and colonization on the surface have caused a severe threat to human healthcare. The development of surface coatings with high antibacterial activity and low toxicity is highly desired. Herein, a series of sulfonium‐co…
View article: Hope Buffers the Effect of Fear of COVID-19 on Depression among College Students: Insomnia as a Mediator
Hope Buffers the Effect of Fear of COVID-19 on Depression among College Students: Insomnia as a Mediator Open
Background: In the period of the global pandemic, psychophysical problems induced by the fear of COVID-19 among college students deserve attention since the dormitory environment in college greatly increases the possibility of COVID-19 inf…