Huimin Zhang
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View article: A novel evaluation benchmark for medical LLMs illuminating safety and effectiveness in clinical domains
A novel evaluation benchmark for medical LLMs illuminating safety and effectiveness in clinical domains Open
Large language models (LLMs) hold promise in clinical decision support but face major challenges in safety evaluation and effectiveness validation. We developed the Clinical Safety-Effectiveness Dual-Track Benchmark (CSEDB), a multidimensi…
View article: Evaluating rituximab against cyclophosphamide or cyclosporine in idiopathic membranous nephropathy: a meta-analysis
Evaluating rituximab against cyclophosphamide or cyclosporine in idiopathic membranous nephropathy: a meta-analysis Open
Rituximab is comparable in efficacy to cyclophosphamide and cyclosporine for IMN treatment, with no significant difference in remission rates or severe adverse events. Treatment should be individualized.
View article: Heavy metal accumulation risk and source analysis in soils of antimony mining areas
Heavy metal accumulation risk and source analysis in soils of antimony mining areas Open
Co-contamination of heavy metals from antimony (Sb) mining poses significant threats to soil quality and human health. Although many studies have examined Sb sources, few have provided quantitative source apportionment combined with popula…
View article: Efficient, Non‐Destructive Transfer of Wafer‐Scale Monolayer MoS <sub>2</sub> by Interface Engineering
Efficient, Non‐Destructive Transfer of Wafer‐Scale Monolayer MoS <sub>2</sub> by Interface Engineering Open
2D layered materials with atomic thicknesses and dangling‐bond‐free flat surfaces hold great potential to overcome the fundamental challenges of current silicon technology, and to develop completely new device architectures and functionali…
View article: Characteristics, management, and outcomes of early symptomatic congenital syphilis in infants at a tertiary specialist hospital in Beijing from 2008 to 2024
Characteristics, management, and outcomes of early symptomatic congenital syphilis in infants at a tertiary specialist hospital in Beijing from 2008 to 2024 Open
Background: The neonate and infant periods are critical time windows for diagnosing and treating congenital syphilis (CS) so as to prevent its adverse outcomes. In order to assist pediatricians in achieving early diagnoses and to standardi…
View article: Control of Conical Intersection Dynamics in CF <sub>3</sub> I Photodissociation via Halogen Bonding
Control of Conical Intersection Dynamics in CF <sub>3</sub> I Photodissociation via Halogen Bonding Open
The dynamics of conical intersections are critical in governing the diverse pathways of chemical reactions, especially in photoexcited polyatomic systems. However, the systematic control of conical intersection dynamics remains a formidabl…
View article: Exploring the evolution of thermal power market participants' strategies under carbon trading policy: An evolutionary game and system dynamics approach
Exploring the evolution of thermal power market participants' strategies under carbon trading policy: An evolutionary game and system dynamics approach Open
In response to climate change, China has implemented a carbon trading market to reduce greenhouse gas emissions from thermal power generation. However, the resulting carbon costs are reshaping the behavior of market participants. This stud…
View article: Complete mole with co-existing fetus: a rare case report of full-term delivery with favorable maternal and fetal outcomes
Complete mole with co-existing fetus: a rare case report of full-term delivery with favorable maternal and fetal outcomes Open
CHMCF belongs to paternal diploid twin pregnancy. Ultrasound and magnetic resonance imaging are important methods for early diagnosis. When the fetal karyotype is normal and there is no obvious pregnancy complication, it is feasible to con…
View article: Alterations in white matter microstructure and structural network topology associated with cortisol level in major depressive disorder patients
Alterations in white matter microstructure and structural network topology associated with cortisol level in major depressive disorder patients Open
MDD patients with different CORT levels show WM microstructure alterations and structural network topology differences, particularly in high-CORTs. These alterations were associated with CORT levels and neuropsychological performance and c…
View article: Stabilized N5 and N6 rings in the Ag–N system under modest pressure
Stabilized N5 and N6 rings in the Ag–N system under modest pressure Open
High pressure enables the creation of novel functional materials by modifying chemical bonding and crystal structure, opening avenues for the development of high-energy-density polynitrogen materials. We present the high-pressure synthesis…
View article: Symmetry-required Orbital Selectivity in Monolayer FeSe
Symmetry-required Orbital Selectivity in Monolayer FeSe Open
Orbital-selective correlations have been observed to play an important role in Fe-based superconductors. Here, in contrast to previous site-local Mott transition-based origins, we present a band-theory-based mechanism for orbital-selective…
View article: Highly Ordered DNA Framework Interface Enables Efficient Enzymatic Oligonucleotide Synthesis
Highly Ordered DNA Framework Interface Enables Efficient Enzymatic Oligonucleotide Synthesis Open
De novo DNA synthesis plays crucial roles in life science. Enzymatic oligonucleotide synthesis (EOS) has attracted interest due to longer synthesized chains, simple procedure, cost‐effectiveness, and environmental friendliness. However, un…
View article: Impacts of Foreign Aid and Investment on Emerging Countries: Grid Cells of Nighttime Light Data Analysis of the Belt and Road Initiative Projects Effects in Central Asia
Impacts of Foreign Aid and Investment on Emerging Countries: Grid Cells of Nighttime Light Data Analysis of the Belt and Road Initiative Projects Effects in Central Asia Open
This study investigates the direct and spillover economic impact of China’s Belt and Road Initiative (BRI) in Central Asia over the period 2012-2022. Remote sensing nighttime light data are utilized due to the inaccessibility of subnationa…
View article: The Weyl bound for triple product L-functions in the cubic level
The Weyl bound for triple product L-functions in the cubic level Open
In this paper, we focus on the strong subconvexity bounds for triple product L-functions in the cubic level aspect. Our proof on the Weyl-type bound synthesizes techniques from classical analytic number theory with methods in automorphic f…
View article: Cadmium induced ferroptosis and inflammation in sheep via targeting ACSL4/NF-κB axis
Cadmium induced ferroptosis and inflammation in sheep via targeting ACSL4/NF-κB axis Open
Introduction Cadmium, a major environmental contaminant, induces progressive intestinal damage through bioaccumulation in vivo . Elucidating its pathogenic mechanisms is crucial for developing therapeutic interventions. Methods This study …
View article: Mechanisms of copper metabolism and cuproptosis: implications for liver diseases
Mechanisms of copper metabolism and cuproptosis: implications for liver diseases Open
Copper is an essential trace element in the human body, involved in various biological processes, including cell metabolism, nerve development, and immune function. Its homeostasis is vital for maintaining normal cellular functions, and di…
View article: PET Imaging Unveils Neuroinflammatory Mechanisms in Psychiatric Disorders: From Microglial Activation to Therapeutic Innovation
PET Imaging Unveils Neuroinflammatory Mechanisms in Psychiatric Disorders: From Microglial Activation to Therapeutic Innovation Open
Recent advancements in neuroinflammation research have significantly enhanced our understanding of its pivotal role in the pathogenesis and pathophysiology of psychiatric disorders. Positron emission tomography (PET) imaging, leveraging it…
View article: Advanced single‐cell RNA sequencing in tumor immunology
Advanced single‐cell RNA sequencing in tumor immunology Open
Cancer immunotherapy is an innovative treatment approach that leverages the immune system to combat tumors, demonstrating significant therapeutic potential. In the past few years, single‐cell RNA sequencing (scRNA‐seq) has made significant…
View article: Numerical Simulation of Wind and Sand Resistance in Three Typical Shrubs
Numerical Simulation of Wind and Sand Resistance in Three Typical Shrubs Open
The sand-laden airflow fields surrounding Artemisia desertorum Spreng., Reaumuria soongorica, and Hedysarum scoparium were investigated. The study focuses on a configuration of double rows with staggered shrub distribution. Computational F…
View article: Hydrophilic hard-magnetic soft robots: A new approach for precise droplet manipulation
Hydrophilic hard-magnetic soft robots: A new approach for precise droplet manipulation Open
Precise droplet manipulation is critical in material synthesis, biochemical detection, and tissue engineering. However, the droplet velocity and volume manipulated by magnetic techniques are restricted owing to the low magnetic force exert…
View article: GWAS identifies a molecular marker cluster associated with monoterpenoids in grapes
GWAS identifies a molecular marker cluster associated with monoterpenoids in grapes Open
Monoterpenoids are vital compounds that impart a distinctive floral flavor. They exist in both glycosidic and free forms in grapes. The breeding of improved monoterpenoid varieties has consistently been a topic of interest, yet only a limi…
View article: Combination of SPH and SP80 prolongs the lifespan of Bacillus subtilis natto to enhance industrial menaquinone-7 biosynthesis
Combination of SPH and SP80 prolongs the lifespan of Bacillus subtilis natto to enhance industrial menaquinone-7 biosynthesis Open
Menaquinone-7 (MK-7) production from renewable feedstocks using Bacillus subtilis natto provides a promising pathway toward sustainability. However, MK-7 yields are often limited by poor microbial cell viability. In this study, a novel fer…
View article: Case Report: A rare case of familial progressive cholestasis type 10 in an adult with heterozygous MYO5B variant
Case Report: A rare case of familial progressive cholestasis type 10 in an adult with heterozygous MYO5B variant Open
Progressive familial intrahepatic cholestasis (PFIC) is a group of rare autosomal recessive cholestatic liver diseases that typically manifest in infancy or childhood. It is characterized by intrahepatic cholestasis, jaundice, pruritus, an…
View article: Establishment and function of the rhizosphere fungal community in rare and endangered plant Alsophila spinulosa
Establishment and function of the rhizosphere fungal community in rare and endangered plant Alsophila spinulosa Open
Introduction The “rhizosphere effect” in plants occurs within approximately 5 mm from the root surface, where microbial communities exhibit distinct species composition and structural characteristics compared to non-rhizospheric soil. Root…
View article: Differences in virulence and drug resistance between <i>Clostridioides difficile</i> ST37 and ST1 isolates
Differences in virulence and drug resistance between <i>Clostridioides difficile</i> ST37 and ST1 isolates Open
One of the most common hospital-acquired infections is caused by toxigenic Clostridioides difficile. Although C. difficile ST37 only produces a functional toxin B, it causes disease as severe as that caused by hypervirulent ST1. We aim to …
View article: Double‐Layer Ordered Conducting Polymers Toward High Stable Iron Anode
Double‐Layer Ordered Conducting Polymers Toward High Stable Iron Anode Open
Aqueous iron (Fe) metal ion batteries have great application possibilities and prospects due to their remarkably low cost and high safety. However, the cycle life of the Fe metal anode is limited by severe corrosion and dendrite growth, wh…
View article: A Study on The Application of Generative Digital Art in Song and Jin Dynasty Opera Brick Carvings in Shanxi
A Study on The Application of Generative Digital Art in Song and Jin Dynasty Opera Brick Carvings in Shanxi Open
This study aims to explore the digital dissemination pathways and cultural heritage approaches of Song and Jin Dynasty opera brick carvings in Shanxi. By leveraging theories related to generative digital art, a design model for applying di…
View article: Scalable acoustic virtual stirrer for enhanced interfacial enzymatic nucleic acid reactions
Scalable acoustic virtual stirrer for enhanced interfacial enzymatic nucleic acid reactions Open
Enzymatic nucleic acid reaction is a fundamental tool in molecular biology. However, high-complexity enzymatic DNA reactions and assays are still challenging due to the difficulties in integrating and scaling up microscale reaction units a…