Jae‐Hong Lee
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View article: The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology
The relationship of soluble tau species with Alzheimer's disease amyloid plaque removal and tau pathology Open
BACKGROUND Tau‐derived cerebrospinal fluid (CSF) biomarkers correlate with amyloid‐beta (Aβ) plaques or tau tangles in Alzheimer's disease (AD). This study assessed the effects of long‐term anti‐Aβ antibodies on amyloid plaques, tau tangle…
View article: ARGS: Advanced Regularization on Aligning Gaussians over the Surface
ARGS: Advanced Regularization on Aligning Gaussians over the Surface Open
Reconstructing high-quality 3D meshes and visuals from 3D Gaussian Splatting(3DGS) still remains a central challenge in computer graphics. Although existing models such as SuGaR offer effective solutions for rendering, there is is still ro…
View article: The Effects of Stair Gait Training on Heart Rate Variability, Respiratory and Balance in Right Hemisphere Stroke Patients: Pilot study
The Effects of Stair Gait Training on Heart Rate Variability, Respiratory and Balance in Right Hemisphere Stroke Patients: Pilot study Open
Purpose This study aimed to investigate the effect of stair gait training on heart rate variability, respiratory and balance in Stroke Patients. Methods This study was a pilot study consisting of 10 patients diagnosed with stroke who met t…
View article: Early increase of the synaptic blood marker β‐synuclein in asymptomatic autosomal dominant Alzheimer's disease
Early increase of the synaptic blood marker β‐synuclein in asymptomatic autosomal dominant Alzheimer's disease Open
INTRODUCTION β‐synuclein is a promising blood marker to track synaptic degeneration in Alzheimer's disease (AD) but changes in preclinical AD are unclear. METHODS We investigated serum β‐synuclein in 69 cognitively unimpaired mutation non‐…
View article: The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset
The landscape of autosomal-dominant Alzheimer’s disease: global distribution and age of onset Open
We present a comprehensive global analysis of genetic variants associated with autosomal-dominant Alzheimer’s disease (ADAD). A total of 550 variants in the APP, PSEN1 and PSEN2 genes were identified, of which 279 were classified as pathog…
View article: Narrative mobile video game-based cognitive training to enhance frontal function in patients with mild cognitive impairment
Narrative mobile video game-based cognitive training to enhance frontal function in patients with mild cognitive impairment Open
Although cognitive training has been proposed as a possible therapeutic modality for mild cognitive impairment (MCI), most serious games focus on specific tasks. This study aimed to investigate the feasibility and efficacy of narrative vid…
View article: Erratum: Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist
Erratum: Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist Open
[This corrects the article on p. 17 in vol. 86, PMID: 39958499.].
View article: Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist
Anti-Amyloid Imaging Abnormality in the Era of Anti-Amyloid Beta Monoclonal Antibodies: Recent Updates for the Radiologist Open
Lecanemab and donanemab have received full U.S. Food and Drug Administration (FDA) approval, and subsequently, lecanemab has been approved by the Korean FDA and it has recently entered commercial use in Korea. This has increased interest i…
View article: Brain Volumetric Trajectories in Down Syndrome and Autosomal Dominant Alzheimer Disease
Brain Volumetric Trajectories in Down Syndrome and Autosomal Dominant Alzheimer Disease Open
Background Alzheimer disease (AD) related cognitive decline occurs at relatively young ages in individuals with Down syndrome (DS, early‐mid 50s) and in those with autosomal dominant mutations (ADAD, 40‐50s). Both groups show similar patte…
View article: Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer’s disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial
Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer’s disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial Open
Summary Background Amyloid-plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer’s disease; however, the potential for delaying the onset of clinical symptoms in asymptomatic people is unknown.…
View article: Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson's Disease: A Genome‐wide Association Study
Identification of Novel Genetic Loci Affecting Age at Onset of Parkinson's Disease: A Genome‐wide Association Study Open
Background The age at onset (AAO) of Parkinson's disease (PD) varies widely among individuals and significantly influences disease progression and prognosis. However, few genome‐wide association studies (GWASs) have investigated genetic va…
View article: Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease
Longitudinal associations between exercise and biomarkers in autosomal dominant Alzheimer's disease Open
INTRODUCTION We investigated longitudinal associations between self‐reported exercise and Alzheimer's disease (AD)‐related biomarkers in individuals with autosomal dominant AD (ADAD) mutations. METHODS Participants were 308 ADAD mutation c…
View article: Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease
Association of Resilience-Related Life Experiences on Variability on Age of Onset in Dominantly Inherited Alzheimer Disease Open
Among the cognitively and socially integrated life experiences associated with resilience, measures of conscientiousness were useful indicators for evaluating resilience and predicting future dementia onset in late preclinical ADAD.
View article: Automated Idiopathic Normal Pressure Hydrocephalus Diagnosis via Artificial Intelligence–Based 3D T1 MRI Volumetric Analysis
Automated Idiopathic Normal Pressure Hydrocephalus Diagnosis via Artificial Intelligence–Based 3D T1 MRI Volumetric Analysis Open
We demonstrated a machine learning algorithm capable of diagnosing iNPH from a 3D T1-weighted MRI that is robust to the failure. We propose a method to scan large numbers of 3D T1-weighted MRIs with minimal human intervention, making possi…
View article: mTOR potentiates senescent phenotypes and primary cilia formation after cisplatin-induced G2 arrest in retinal pigment epithelial cells
mTOR potentiates senescent phenotypes and primary cilia formation after cisplatin-induced G2 arrest in retinal pigment epithelial cells Open
Cisplatin, a platinum-based anticancer drug, is used to treat several types of cancer. Despite its effectiveness, cisplatin-induced side effects have often been reported. Although cisplatin-induced toxicities, such as apoptosis and/or necr…
View article: 15 Years of Longitudinal Genetic, Clinical, Cognitive, Imaging, and Biochemical Measures in DIAN
15 Years of Longitudinal Genetic, Clinical, Cognitive, Imaging, and Biochemical Measures in DIAN Open
This manuscript describes and summarizes the Dominantly Inherited Alzheimer Network Observational Study (DIAN Obs), highlighting the wealth of longitudinal data, samples, and results from this human cohort study of brain aging and a rare m…
View article: α‐Synuclein seed amplification assay detects Lewy body co‐pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden
α‐Synuclein seed amplification assay detects Lewy body co‐pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden Open
INTRODUCTION Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. METHODS Using an α‐synuclein s…
View article: Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study
Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study Open
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View article: Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging
Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging Open
This research was supported by the Knight Alzheimer Disease Research Center (Knight ADRC, NIH grants P30AG066444, P01AG026276, P01AG003991), Dominantly Inherited Alzheimer Network (DIAN, NIH grants U01AG042791, U19AG03243808, R01AG052550-0…
View article: Development of statistical auto-segmentation method for diffusion restriction gray matter lesions in patients with newly diagnosed sporadic Creutzfeldt–Jakob disease
Development of statistical auto-segmentation method for diffusion restriction gray matter lesions in patients with newly diagnosed sporadic Creutzfeldt–Jakob disease Open
Quantification of diffusion restriction lesions in sporadic Creutzfeldt-Jakob disease (sCJD) may provide information of the disease burden. We aim to develop an automatic segmentation model for sCJD and to evaluate the volume of disease ex…
View article: One-Year Longitudinal Changes in Tau Accumulation on [<sup>18</sup>F]PI-2620 PET in the Alzheimer Spectrum
One-Year Longitudinal Changes in Tau Accumulation on [<sup>18</sup>F]PI-2620 PET in the Alzheimer Spectrum Open
We investigated the longitudinal changes in cortical tau accumulation and their association with cognitive decline in patients in the Alzheimer disease (AD) continuum using 2-(2-([18F]fluoro)pyridin-4-yl)-9H-pyrrolo[2,3-b:4,5c']dipyridine …
View article: Narrative Mobile Video Game-based Cognitive Training to Enhance Frontal Function in Patients with Mild Cognitive Impairment
Narrative Mobile Video Game-based Cognitive Training to Enhance Frontal Function in Patients with Mild Cognitive Impairment Open
Although cognitive training has been proposed as a possible therapeutic modality for mild cognitive impairment (MCI), most serious games focus on specific tasks. This study aimed to investigate the feasibility and efficacy of narrative vid…
View article: A Two-Year Observational Study to Evaluate Conversion Rates from High- and Low-Risk Patients with Amnestic Mild Cognitive Impairment to Probable Alzheimer’s Disease in a Real-World Setting
A Two-Year Observational Study to Evaluate Conversion Rates from High- and Low-Risk Patients with Amnestic Mild Cognitive Impairment to Probable Alzheimer’s Disease in a Real-World Setting Open
Background: Predicting conversion to probable Alzheimer&s disease (AD) from amnestic mild cognitive impairment (aMCI) is difficult but important. A nomogram was developed previously for determining the risk of 3-year probable AD conversion…
View article: Amyloid-Related Imaging Abnormalities in the Era of Anti-Amyloid Beta Monoclonal Antibodies for Alzheimer’s Disease: Recent Updates on Clinical and Imaging Features and MRI Monitoring
Amyloid-Related Imaging Abnormalities in the Era of Anti-Amyloid Beta Monoclonal Antibodies for Alzheimer’s Disease: Recent Updates on Clinical and Imaging Features and MRI Monitoring Open
Recent advancements in Alzheimer's disease treatment have focused on the elimination of amyloid-beta (Aβ) plaque, a hallmark of the disease. Monoclonal antibodies such as lecanemab and donanemab can alter disease progression by binding to …
View article: Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease
Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease Open
Background “Brain-predicted age” estimates biological age from complex, nonlinear features in neuroimaging scans. The brain age gap (BAG) between predicted and chronological age is elevated in sporadic Alzheimer disease (AD), but is undere…