Shemin Lu
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View article: Mechanical Force‐Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis
Mechanical Force‐Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis Open
Liver metastasis is the main cause of cancer‐related mortality. During the metastasis process, circulating carcinoma cells hardly pass through narrow capillaries, leading to nuclear deformation. However, the effects of nuclear deformation …
View article: How components of ESG performance impact corporate risk-taking?
How components of ESG performance impact corporate risk-taking? Open
Corporate risk-taking (CRT) is crucial for sustainable business development. The focus of this study is to examine the relationship between components of ESG performance (ESGP) and corporate risk-taking. We conduct an empirical analysis us…
View article: Depression of CaV1.2 activation and expression in mast cells ameliorates allergic inflammation diseases
Depression of CaV1.2 activation and expression in mast cells ameliorates allergic inflammation diseases Open
Allergic inflammation is closely related to the activation of mast cells (MCs), which is regulated by its intracellular Ca2+ level, but the intake and effects of the intracellular Ca2+ remain unclear. The Ca2+
View article: Clinical and hematological characteristics of children infected with the omicron variant of SARS-CoV-2: role of the combination of the neutrophil: lymphocyte ratio and eosinophil count in distinguishing severe COVID-19
Clinical and hematological characteristics of children infected with the omicron variant of SARS-CoV-2: role of the combination of the neutrophil: lymphocyte ratio and eosinophil count in distinguishing severe COVID-19 Open
Purpose Investigate the clinical/hematological characteristics of children infected with the Omicron variant of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and identify an effective indicator to distinguish coronavirus dis…
View article: Exploring therapeutic targets for molecular therapy of idiopathic pulmonary fibrosis
Exploring therapeutic targets for molecular therapy of idiopathic pulmonary fibrosis Open
Idiopathic pulmonary fibrosis is a chronic and progressive interstitial lung disease with a poor prognosis. Idiopathic pulmonary fibrosis is characterized by repeated alveolar epithelial damage leading to abnormal repair. The intercellular…
View article: NCF4 regulates antigen presentation of cysteine peptides by intracellular oxidative response and restricts activation of autoreactive and arthritogenic T cells
NCF4 regulates antigen presentation of cysteine peptides by intracellular oxidative response and restricts activation of autoreactive and arthritogenic T cells Open
View article: Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4
Selenium binding protein 1 protects renal tubular epithelial cells from ferroptosis by upregulating glutathione peroxidase 4 Open
Ferroptosis is a form of programmed cell death involved in various types of acute kidney injury (AKI). It is characterized by inactivation of the selenoprotein, glutathione peroxidase 4 (GPX4), and upregulation of acyl-CoA synthetase long-…
View article: Association between C-reactive protein to lymphocyte ratio and rheumatoid arthritis risk among adults in NHANES, 2017–2020
Association between C-reactive protein to lymphocyte ratio and rheumatoid arthritis risk among adults in NHANES, 2017–2020 Open
Background and Objectives:There is a limited number of studies that have investigated the association between C-reactive protein to lymphocyte ratio (CLR) and rheumatoid arthritis (RA). The aim of this study was to evaluate the potential r…
View article: Ncf4 Regulate Macrophage Presentation of Cysteine Peptides by Intracellular Oxidative Response, Restricting Activation of Autoreactive and Arthritogenic T Cells
Ncf4 Regulate Macrophage Presentation of Cysteine Peptides by Intracellular Oxidative Response, Restricting Activation of Autoreactive and Arthritogenic T Cells Open
View article: Editorial: Immunometabolism in autoimmune and autoinflammatory disorders
Editorial: Immunometabolism in autoimmune and autoinflammatory disorders Open
EDITORIAL article Front. Immunol., 01 November 2023Sec. Inflammation Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1285720
View article: Adipose tissue macrophages as potential targets for obesity and metabolic diseases
Adipose tissue macrophages as potential targets for obesity and metabolic diseases Open
Macrophage infiltration into adipose tissue is a key pathological factor inducing adipose tissue dysfunction and contributing to obesity-induced inflammation and metabolic disorders. In this review, we aim to present the most recent resear…
View article: Shcbp1 deficiency dampens chondrocyte viability and cartilage ECM homeostasis via disturbing coordination of Akt and Erk signal pathways
Shcbp1 deficiency dampens chondrocyte viability and cartilage ECM homeostasis via disturbing coordination of Akt and Erk signal pathways Open
Shcbp1 is known to participate in important signaling pathways related to growth and differentiation, but its role in cartilage has not been well understood. Our previous study found that the expression of Shcbp1 in cartilage is lower in p…
View article: LncRNA WDR11-AS1 Promotes Extracellular Matrix Synthesis in Osteoarthritis by Directly Interacting with RNA-Binding Protein PABPC1 to Stabilize SOX9 Expression
LncRNA WDR11-AS1 Promotes Extracellular Matrix Synthesis in Osteoarthritis by Directly Interacting with RNA-Binding Protein PABPC1 to Stabilize SOX9 Expression Open
Osteoarthritis (OA) is a degenerative disease of articular cartilage that is mainly characterized by chronic and mild inflammation of the joints. Recently, many studies have reported the crucial roles of long noncoding RNAs (lncRNAs) in OA…
View article: Successful Transfection of MicroRNA Mimics or Inhibitors in a Regular Cell Line and in Primary Cells Derived from Patients with Rheumatoid Arthritis
Successful Transfection of MicroRNA Mimics or Inhibitors in a Regular Cell Line and in Primary Cells Derived from Patients with Rheumatoid Arthritis Open
The transfection of microRNA (miRNA) mimics and inhibitors can lead to the gain and loss of intracellular miRNA function, helping us better understand the role of miRNA during gene expression regulation under specific physical conditions. …
View article: Correction: Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage
Correction: Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage Open
View article: Evaluation of immunoprotection against coronavirus disease 2019: Novel variants, vaccine inoculation, and complications
Evaluation of immunoprotection against coronavirus disease 2019: Novel variants, vaccine inoculation, and complications Open
The strikingly rapidly mutating nature of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome has been a constant challenge during the coronavirus disease 2019 (COVID-19) pandemic. In this study, various techniques, inc…
View article: Real-world effectiveness and protection of SARS-CoV-2 vaccine among patients hospitalized for COVID-19 in Xi’an, China, December 8, 2021, to January 20, 2022: A retrospective study
Real-world effectiveness and protection of SARS-CoV-2 vaccine among patients hospitalized for COVID-19 in Xi’an, China, December 8, 2021, to January 20, 2022: A retrospective study Open
Introduction In December 2021, a large-scale epidemic broke out in Xi’an, China, due to SARS-CoV-2 infection. This study reports the effect of vaccination on COVID-19 and evaluates the impact of different vaccine doses on routine laborator…
View article: Extrahepatic factors in hepatic immune regulation
Extrahepatic factors in hepatic immune regulation Open
The liver is a site of complex immune activity. The hepatic immune system tolerates harmless immunogenic loads in homeostasis status, shelters liver function, while maintaining vigilance against possible infectious agents or tissue damage …
View article: Risk Factors Associated With Increased Anxiety Sensitivity in Children and Adolescents in Northwest China During COVID-19 Pandemic Lockdown
Risk Factors Associated With Increased Anxiety Sensitivity in Children and Adolescents in Northwest China During COVID-19 Pandemic Lockdown Open
Purpose A large body of evidence has revealed that the sudden outbreak of public health emergencies induces dramatic effects on the mental health of the general public. We aimed to investigate the level of anxiety sensitivity and its risk …
View article: Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma
Neuro-Immune Regulation in Inflammation and Airway Remodeling of Allergic Asthma Open
Allergic asthma is a common chronic inflammation of the airways and causes airway remodeling eventually. For a long time, investigators have been focusing on the immunological mechanism of asthma. However, in recent years, the role of neur…
View article: Corrigendum: Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity
Corrigendum: Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity Open
[This corrects the article DOI: 10.3389/fphar.2022.780148.].
View article: Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation inhibits cell autophagy in pathogenesis of NAFLD
Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation inhibits cell autophagy in pathogenesis of NAFLD Open
The cholesterol-dependent upregulation of LAP3 in hepatocytes plays a critical role in the pathogenesis of NAFLD via inhibiting autophagy. Moreover, LAP3 could serve as a potential novel candidate biomarker for the diagnosis of NAFLD.
View article: Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity
Metformin Ameliorates Inflammation and Airway Remodeling of Experimental Allergic Asthma in Mice by Restoring AMPKα Activity Open
Metformin has been involved in modulating inflammatory state and inhibiting cell proliferation and angiogenesis. This study aimed to determine whether metformin alleviates airway inflammation and remodeling of experimental allergic asthma …
View article: Topical Treatment of Colquhounia Root Relieves Skin Inflammation and Itch in Imiquimod-Induced Psoriasiform Dermatitis in Mice
Topical Treatment of Colquhounia Root Relieves Skin Inflammation and Itch in Imiquimod-Induced Psoriasiform Dermatitis in Mice Open
Itch is one of the major clinical manifestations of psoriasis, which is closely related with neurogenic inflammation and difficult to control. Colquhounia Root (CR) is a Chinese herb exhibiting broad bioactivities on anti-inflammation. Thi…
View article: Design, synthesis, and evaluation of fluoroquinolone derivatives as microRNA-21 small-molecule inhibitors
Design, synthesis, and evaluation of fluoroquinolone derivatives as microRNA-21 small-molecule inhibitors Open
View article: Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice
Ncf1 Governs Immune Niches in the Lung to Mediate Pulmonary Inflammation in Mice Open
Neutrophil cytosolic factor 1 ( Ncf1 ) is a major genetic factor associated with autoimmune diseases and has been identified as a key player in autoimmune mediated inflammation. We addressed the role of Ncf1 in an antigen-induced pulmonary…
View article: Loss of microRNA‐147 function alleviates synovial inflammation through ZNF148 in rheumatoid and experimental arthritis
Loss of microRNA‐147 function alleviates synovial inflammation through ZNF148 in rheumatoid and experimental arthritis Open
MicroRNA‐147 (miR‐147) had been previously found induced in synoviocytes by inflammatory stimuli derived from T cells in experimental arthritis. This study was designed to verify whether loss of its function might alleviate inflammatory ev…
View article: Identification of a cartilage specific novel miRNA which directly targets PRMT3 in rats
Identification of a cartilage specific novel miRNA which directly targets PRMT3 in rats Open
Overall, this study provides the first comprehensive evidence that a genuine cartilage-specific novel miRNA directly targets PRMT3 and may regulate multitudinous cellular processes and signal transduction during cartilage development.
View article: Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection
Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection Open
View article: Author response for "Loss of microRNA‐147 function alleviates synovial inflammation through ZNF148 in rheumatoid and experimental arthritis"
Author response for "Loss of microRNA‐147 function alleviates synovial inflammation through ZNF148 in rheumatoid and experimental arthritis" Open