Min Suk Shim
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View article: Polysorbate-Based Carriers Encapsulating Oxygen-Deficient Nanoparticles for Targeted and Effective Chemo-Sonodynamic Therapy of Glioblastoma
Polysorbate-Based Carriers Encapsulating Oxygen-Deficient Nanoparticles for Targeted and Effective Chemo-Sonodynamic Therapy of Glioblastoma Open
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with a high recurrence rate and mortality. A major obstacle to the effective treatment of GBM is the blood–brain barrier (BBB), which hinders the transfer of therapeutic carg…
View article: Tumor‐Targeted Exosome‐Based Heavy Atom‐Free Nanosensitizers With Long‐Lived Excited States for Safe and Effective Sono‐Photodynamic Therapy of Solid Tumors
Tumor‐Targeted Exosome‐Based Heavy Atom‐Free Nanosensitizers With Long‐Lived Excited States for Safe and Effective Sono‐Photodynamic Therapy of Solid Tumors Open
Theranostic nanosensitizers with combined near‐infrared (NIR) fluorescence imaging and sono‐photodynamic effects have great potential for use in the personalized treatment of deep‐seated tumors. However, developing effective nanosensitizer…
View article: Effect of Thermal Aging on a Urethane Acrylate-Based 3d Printing Resin Incorporated with Antibacterial Quaternary Ammonium Methacrylate
Effect of Thermal Aging on a Urethane Acrylate-Based 3d Printing Resin Incorporated with Antibacterial Quaternary Ammonium Methacrylate Open
View article: Ziziphus jujuba Miller Ethanol Extract Restores Disrupted Intestinal Barrier Function via Tight Junction Recovery and Reduces Inflammation
Ziziphus jujuba Miller Ethanol Extract Restores Disrupted Intestinal Barrier Function via Tight Junction Recovery and Reduces Inflammation Open
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by the disruption of the intestinal barrier. The intestinal barrier is maintained by tight junctions (TJs), which sustain intestinal homeostasis and prevent pathog…
View article: Oxygen‐Supplying Piezocatalytic Therapy of Hypoxic Tumors by Intratumoral Delivery of pH‐Responsive Multicompartmental Carriers with Sequential Drug Release Capability (Adv. Funct. Mater. 21/2024)
Oxygen‐Supplying Piezocatalytic Therapy of Hypoxic Tumors by Intratumoral Delivery of pH‐Responsive Multicompartmental Carriers with Sequential Drug Release Capability (Adv. Funct. Mater. 21/2024) Open
Piezocatalytic Cancer Therapy In article number 2306078, Suk Ho Bhang, Min Suk Shim, Ki Wan Bong, and co-workers develop pH-responsive Janus-type multicompartmental carriers, encapsulating piezocatalytic gold nanoparticle-coated ZnO nanoro…
View article: Efficient Combination Chemo-Sonodynamic Cancer Therapy Using Mitochondria-Targeting Sonosensitizer-Loaded Polysorbate-Based Micelles
Efficient Combination Chemo-Sonodynamic Cancer Therapy Using Mitochondria-Targeting Sonosensitizer-Loaded Polysorbate-Based Micelles Open
Sonodynamic therapy (SDT), utilizing ultrasound (US) and sonosensitizers, holds immense potential as a noninvasive and targeted treatment for a variety of deep-seated tumors. However, the clinical translation of SDT is hampered by several …
View article: Beyond Nanoparticle‐Based Intracellular Drug Delivery: Cytosol/Organelle‐Targeted Drug Release and Therapeutic Synergism
Beyond Nanoparticle‐Based Intracellular Drug Delivery: Cytosol/Organelle‐Targeted Drug Release and Therapeutic Synergism Open
Nanoparticle (NP)‐based drug delivery systems are conceived to solve poor water‐solubility and chemical/physical instability, and their purpose expanded to target specific sites for maximizing therapeutic effects and minimizing unwanted ev…
View article: Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting
Beyond nanoparticle-based oral drug delivery: transporter-mediated absorption and disease targeting Open
GI transporter/receptor-mediated nanosized drug delivery systems could improve oral absorption and further target organs or diseases for effective therapeutic outcomes.
View article: Piezocatalytic 2D WS<sub>2</sub> Nanosheets for Ultrasound‐Triggered and Mitochondria‐Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism‐Targeted Chemotherapy (Adv. Mater. 18/2023)
Piezocatalytic 2D WS<sub>2</sub> Nanosheets for Ultrasound‐Triggered and Mitochondria‐Targeted Piezodynamic Cancer Therapy Synergized with Energy Metabolism‐Targeted Chemotherapy (Adv. Mater. 18/2023) Open
Piezodynamic Cancer Therapy In article number 2300437, Tae Il Lee, Min Suk Shim, and co-workers develop piezocatalytic 2D WS2 nanosheets incorporated with mitochondria-targeting moieties and glycolysis inhibitors. The piezoelectric 2D WS2 …
View article: Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier
Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier Open
View article: Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy
Engineered extracellular vesicle-based sonotheranostics for dual stimuli-sensitive drug release and photoacoustic imaging-guided chemo-sonodynamic cancer therapy Open
Sonodynamic therapy has shown promise as an effective alternative to conventional photodynamic therapy owing to its ability to treat deep-seated tumors. However, the development of stimuli-responsive sonosensitizers with high biocompatibil…
View article: Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy
Polysorbate-Based Drug Formulations for Brain-Targeted Drug Delivery and Anticancer Therapy Open
Polysorbates (PSs) are synthetic nonionic surfactants consisting of polyethoxy sorbitan fatty acid esters. PSs have been widely employed as emulsifiers and stabilizers in various drug formulations and food additives. Recently, various PS-b…
View article: Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1
Metformin and Dichloroacetate Suppress Proliferation of Liver Cancer Cells by Inhibiting mTOR Complex 1 Open
The Warburg effect is important for cancer cell proliferation. This phenomenon can be flexible by interaction between glycolysis and mitochondrial oxidation for energy production. We aimed to investigate the anticancer effects of the pyruv…
View article: Effects of Decomplexation Rates on Ternary Gene Complex Transfection with α-Poly(l-Lysine) or ε-Poly(l-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell
Effects of Decomplexation Rates on Ternary Gene Complex Transfection with α-Poly(l-Lysine) or ε-Poly(l-Lysine) as a Decomplexation Controller in An Easy-To-Transfect Cell or A Hard-To-Transfect Cell Open
The tight binding of pDNA with a cationic polymer is the crucial requirement that prevents DNA degradation from undesired DNase attack to safely deliver the pDNA to its target site. However, cationic polymer-mediated strong gene holding li…
View article: Selective Anticancer Therapy Using Pro-Oxidant Drug-Loaded Chitosan–Fucoidan Nanoparticles
Selective Anticancer Therapy Using Pro-Oxidant Drug-Loaded Chitosan–Fucoidan Nanoparticles Open
Pro-oxidant therapy exploiting pro-oxidant drugs that can trigger cytotoxic oxidative stress in cancer cells has emerged as an innovative strategy for cancer-specific therapy. Piperlongumine (PL) has gained great interest as a novel pro-ox…
View article: Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating
Preparation, Characterization and Biological Applications of Biosynthesized Silver Nanoparticles with Chitosan-Fucoidan Coating Open
Silver nanoparticles (AgNPs) are gaining a great deal of attention in biomedical applications due to their unique physicochemical properties. In this study, green synthesis of AgNPs was developed using seaweed polysaccharide fucoidan. The …
View article: Studies on three-phase three-dimensional hybrid electrochemical reactor for treating textile effluent
Studies on three-phase three-dimensional hybrid electrochemical reactor for treating textile effluent Open
View article: Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives
Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes: current strategies and future perspectives Open
Mitochondrial targeting is a promising approach for solving current issues in clinical application of chemotherapy and diagnosis of several disorders. Here, we discuss direct conjugation of mitochondrial-targeting moieties to anticancer dr…
View article: Successful Lightwand-Guided Intubation in a Patient with Long Standing Ankylosing Spondylitis Who Had Failed Intubation with Other Intubation Tools
Successful Lightwand-Guided Intubation in a Patient with Long Standing Ankylosing Spondylitis Who Had Failed Intubation with Other Intubation Tools Open
Tracheal intubation in patients with cervical arthroplasty with occlusion of the upper airway frequently poses great difficulty.The purpose of this case study was to discuss lightwand tracheal intubation in patients with ankylosing spondyl…
View article: Bioreducible Polymer Micelles Based on Acid-Degradable Poly(ethylene glycol)-poly(amino ketal) Enhance the Stromal Cell-Derived Factor-1α Gene Transfection Efficacy and Therapeutic Angiogenesis of Human Adipose-Derived Stem Cells
Bioreducible Polymer Micelles Based on Acid-Degradable Poly(ethylene glycol)-poly(amino ketal) Enhance the Stromal Cell-Derived Factor-1α Gene Transfection Efficacy and Therapeutic Angiogenesis of Human Adipose-Derived Stem Cells Open
Adipose-derived stem cells (ADSCs) have the potential to treat ischemic diseases. In general, ADSCs facilitate angiogenesis by secreting various pro-angiogenic growth factors. However, transplanted ADSCs have a low therapeutic efficacy in …
View article: Transradial versus transfemoral intervention in ST-segment elevation myocardial infarction patients in Korean population
Transradial versus transfemoral intervention in ST-segment elevation myocardial infarction patients in Korean population Open
BACKGROUND/AIMS: Transradial intervention (TRI) is becoming the preferred method over transfemoral intervention (TFI) because TRI is associated with lower incidence of major bleeding and vascular complications. However, there has been limi…
View article: Marine Fish Proteins and Peptides for Cosmeceuticals: A Review
Marine Fish Proteins and Peptides for Cosmeceuticals: A Review Open
Marine fish provide a rich source of bioactive compounds such as proteins and peptides. The bioactive proteins and peptides derived from marine fish have gained enormous interest in nutraceutical, pharmaceutical, and cosmeceutical industri…
View article: Antimicrobial, Antioxidant, and Anticancer Activities of Biosynthesized Silver Nanoparticles Using Marine Algae Ecklonia cava
Antimicrobial, Antioxidant, and Anticancer Activities of Biosynthesized Silver Nanoparticles Using Marine Algae Ecklonia cava Open
Green synthesis of silver nanoparticles (AgNPs) has gained great interest as a simple and eco-friendly alternative to conventional chemical methods. In this study, AgNPs were synthesized by using extracts of marine algae Ecklonia cava as r…
View article: Impact of Renin‐Angiotensin System Inhibitors on Long‐Term Clinical Outcomes of Patients With Coronary Artery Spasm
Impact of Renin‐Angiotensin System Inhibitors on Long‐Term Clinical Outcomes of Patients With Coronary Artery Spasm Open
Background Coronary artery spasm ( CAS ) is a well‐known endothelial dysfunction, and a major cause of vasospastic angina ( VSA ). The renin–angiotensin system ( RAS ) is known to be closely associated with endothelial function. However, t…
View article: Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials
Targeted and effective photodynamic therapy for cancer using functionalized nanomaterials Open
Photodynamic therapy (PDT) is an emerging, non-invasive therapeutic strategy that involves photosensitizer (PS) drugs and external light for the treatment of diseases. Despite the great progress in PS-mediated PDT, their clinical applicati…
View article: Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery
Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery Open
In recent years, there have been major advances and increasing amounts of research on the utilization of natural polymeric materials as drug delivery vehicles due to their biocompatibility and biodegradability. Seaweed polysaccharides are …
View article: Impact of Cigarette Smoking: a 3-Year Clinical Outcome of Vasospastic Angina Patients
Impact of Cigarette Smoking: a 3-Year Clinical Outcome of Vasospastic Angina Patients Open
Background and Objectives: Cigarette smoking is a risk significant factor in coronary artery disease (CAD) and vasospastic angina (VSA).However, it is largely unknown whether smoking adds to any long-term clinical risk in VSA patients.Subj…