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View article: Proteomic profiling reveals age-related changes in transporter proteins in the human blood–brain barrier
Proteomic profiling reveals age-related changes in transporter proteins in the human blood–brain barrier Open
The Blood–Brain Barrier (BBB) is a selective barrier that regulates the entry of molecules including nutrients, environmental toxins, and therapeutic medications into the brain. Its function continues to evolve postnatally, through aging, …
View article: Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier
Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier Open
The Blood-Brain Barrier (BBB) is a crucial, selective barrier that regulates the entry of molecules including nutrients, environmental toxins, and therapeutic medications into the brain. This function relies heavily on brain endothelial ce…
View article: Characterization of P‐glycoprotein orthologs from human, sheep, pig, dog, and cat
Characterization of P‐glycoprotein orthologs from human, sheep, pig, dog, and cat Open
The ATP‐binding cassette transporter P‐glycoprotein (P‐gp) limits the oral bioavailability of many drugs. Although P‐gp has been well studied in humans and mice, little is known about the substrate specificities of many of its species orth…
View article: The Effect of Trimethoprim on Thiamine Absorption: A <scp>Transporter‐Mediated Drug‐Nutrient</scp> Interaction
The Effect of Trimethoprim on Thiamine Absorption: A <span>Transporter‐Mediated Drug‐Nutrient</span> Interaction Open
Trimethoprim is predicted to inhibit several thiamine transporters, including the primary thiamine intestinal absorptive transporter, ThTR‐2, and the hepatic and renal organic cation transporters, OCT1, OCT2, and MATEs. To investigate the …
View article: High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3
High Throughput Screening of a Prescription Drug Library for Inhibitors of Organic Cation Transporter 3, OCT3 Open
Introduction The organic cation transporter 3 (OCT3, SLC22A3) is ubiquitously expressed and interacts with a wide array of compounds including endogenous molecules, environmental toxins and prescription drugs. Understudied as a determinant…
View article: Jagged1 protein processing in the developing mammalian lens
Jagged1 protein processing in the developing mammalian lens Open
Notch signaling regulates a multitude of cellular processes. During ocular lens development this pathway is required for lens progenitor growth, differentiation, and maintenance of the transition zone. After ligand-receptor binding, the re…
View article: Fabrication and Characterization of Core/shell ZnO/Gold Nanostructures" and study of their Structural and Optical Properties
Fabrication and Characterization of Core/shell ZnO/Gold Nanostructures" and study of their Structural and Optical Properties Open
Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It prov…
View article: The Healing Effect of Amniotic Membrane in Burn Patients.
The Healing Effect of Amniotic Membrane in Burn Patients. Open
It seems use of amnion for dressing of donor site probably cause rapid epithelialisation and wound healing and can improve pain and move score in early post operative days. Accordingly it is expected to need less analgesia and low rate of …