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View article: Buspirone combats cyclophosphamide-provoked hepatotoxicity in rats via activation of AMPK/Nrf2/HO-1 and suppression of NF-κB p65 /NLRP3 inflammasome pathways
Buspirone combats cyclophosphamide-provoked hepatotoxicity in rats via activation of AMPK/Nrf2/HO-1 and suppression of NF-κB p65 /NLRP3 inflammasome pathways Open
This study aims to evaluate the protective effect of buspirone (BUS) against liver damage caused by cyclophosphamide (CPA) by focusing on the α-klotho/Nrf2/HO-1 and AMPK/NF-κB p65/NLRP3/caspase-1 signaling cascades. The possible damage tha…
View article: Unraveling chemotherapy-evoked hepatic dysfunction: a deep dive into cyclophosphamide-related liver injury
Unraveling chemotherapy-evoked hepatic dysfunction: a deep dive into cyclophosphamide-related liver injury Open
Cyclophosphamide (CPA) is an alkylating drug utilized in the treatment of several cancers and autoimmune illnesses. Liver injury is a serious adverse effect linked to the administration of CPA. Nonetheless, the mechanism behind this toxici…
View article: Obeticholic acid prevents cyclophosphamide-induced placental injury via SIRT1 and TLR4/NF-κB pathways
Obeticholic acid prevents cyclophosphamide-induced placental injury via SIRT1 and TLR4/NF-κB pathways Open
Background The aim of the current study is to identify the possible protective effect of obeticholic acid (OCA) on placental injury caused by cyclophosphamide (CP). OCA was administered in the presence and absence of CP. Methods Thirty-two…
View article: Mitigation of sepsis-induced liver injury by Clemastine via modulating GSDMD/NLRP-3/Caspase-1/NF-κB signalling pathways
Mitigation of sepsis-induced liver injury by Clemastine via modulating GSDMD/NLRP-3/Caspase-1/NF-κB signalling pathways Open
View article: Modulating platelet-activating factor by rupatadine attenuates gentamicin-induced nephrotoxicity in rats via NF-κB/caspase-3 and Nrf2/HO-1 signaling cascades
Modulating platelet-activating factor by rupatadine attenuates gentamicin-induced nephrotoxicity in rats via NF-κB/caspase-3 and Nrf2/HO-1 signaling cascades Open
Gentamicin (GEN) is a commonly prescribed antibiotic for Gram-negative bacterial infections. One of the most common adverse consequences of it is renal damage which is developed in 30% of individuals receiving GEN for over 7 days. For the …
View article: Memantine abrogates testicular dysfunction induced by risperidone in rats with a potential role of ERK1/2-Nrf2-caspase-3 signaling pathway
Memantine abrogates testicular dysfunction induced by risperidone in rats with a potential role of ERK1/2-Nrf2-caspase-3 signaling pathway Open
Psychosis is usually a substantial global burden with a prevalence of 0.4–2%. On the other hand, 50 million people are suffering from dementia, with dementia-related psychosis affecting approximately 25% of them. The current experiment aim…
View article: Vincamine exerts hepato-protective activity during colon ligation puncture-induced sepsis by modulating oxidative stress, apoptosis, and TNFα/Nrf-2/Keap-1 signaling pathways
Vincamine exerts hepato-protective activity during colon ligation puncture-induced sepsis by modulating oxidative stress, apoptosis, and TNFα/Nrf-2/Keap-1 signaling pathways Open
View article: The protective effect of vinpocetine against Estradiol-benzoate induced cervical hyperkeratosis in female rats via modulation of SIRT1/Nrf2, and NLRP3 inflammasome
The protective effect of vinpocetine against Estradiol-benzoate induced cervical hyperkeratosis in female rats via modulation of SIRT1/Nrf2, and NLRP3 inflammasome Open
View article: Effect of hepatic ischemia reperfusion on testicular tissue in rats
Effect of hepatic ischemia reperfusion on testicular tissue in rats Open
Background: Hepatic ischemia reperfusion (HIR) injury is a major cause of liver damage occurring in many surgical circumstances such as liver transplantation resulting in tissue injury and remote organ affection which are dangerous medical…
View article: <b>Potential induction of </b>h<b>yperkeratosis in </b>r<b>ats’ </b>c<b>ervi by gentamicin via induction of oxidative </b>s<b>tress, </b>i<b>nflammation and </b>a<b>poptosis</b>
<b>Potential induction of </b>h<b>yperkeratosis in </b>r<b>ats’ </b>c<b>ervi by gentamicin via induction of oxidative </b>s<b>tress, </b>i<b>nflammation and </b>a<b>poptosis</b> Open
The present study aimed to identify the possible effect of gentamicin (GEN) in Rats’ Cervi. Estradiol Valerate (EV) was used to induce cervical hyperkeratosis. GEN was administered in absence of EV. Serum and cervical GEN concentration wer…
View article: Modulating Nrf-2/HO-1, apoptosis and oxidative stress signaling pathways by gabapentin ameliorates sepsis-induced acute kidney injury
Modulating Nrf-2/HO-1, apoptosis and oxidative stress signaling pathways by gabapentin ameliorates sepsis-induced acute kidney injury Open
Purpose Globally, sepsis, which is a major health issue resulting from severe infection-induced inflammation, is the fifth biggest cause of death. This research aimed to evaluate, for the first time, the molecular effects of gabapentin's p…
View article: LC-MS-based identification of bioactive compounds and hepatoprotective and nephroprotective activities of Bignonia binata leaves against carbon tetrachloride-induced injury in rats
LC-MS-based identification of bioactive compounds and hepatoprotective and nephroprotective activities of Bignonia binata leaves against carbon tetrachloride-induced injury in rats Open
The chemical profiling of the main phytoconstituents of total ethanolic extract (TEE) and its different fractions of Bignonia binata leaves was dereplicated using liquid chromatography-high resolution-electrospray ionisation-mass spectrome…
View article: Protective activity of phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway
Protective activity of phalaris canariensis against methotrexate-induced nephrotoxicity via BCL2 pathway Open
This study aimed to evaluate the protective effects of the ethanolic extract obtained from the seeds of phalaris canariensis, against nephro-toxicity induced by methotrexate (MTX).Toxicity was induced by a single dose of MTX (20 mg/kg) and…