Mina Ibrahim Tadros
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Intravitreal vascular endothelial growth factor inhibitor systemic and renal toxicity registry Open
Background Intravitreal vascular endothelial growth factor inhibitors (IVEGFi) are used in the treatment of diabetic retinopathy, age-related macular degeneration (AMD) and central retinal vein obstruction. As we have previously reported, …
BRINZOLAMIDE-LOADED ETHO-LECIPLEX FOR EFFECTIVE OCULAR MANAGEMENT OF GLAUCOMA: D-OPTIMAL DESIGN OPTIMIZATION AND IN VIVO EVALUATION Open
Objective: Brinzolamide (BRZ) is an active carbonic anhydrase inhibitor adopted for glaucoma management. The limited aqueous solubility of the drug restricts its potential for ocular administration. Therefore, the aim of this investigation…
Development of vardenafil hydrochloride-loaded silica nanoparticles with enhanced transdermal delivery Open
The aim of the present study was to develop a promising silica nanoparticle system to enhance the transdermal delivery of vardenafil hydrochloride (VRD) for treatment of erectile dysfunction.VRD-loaded silica nanoparticles were prepared us…
Development and Characterization of PLGA Nanoparticle-Laden Hydrogels for Sustained Ocular Delivery of Norfloxacin in the Treatment of Pseudomonas Keratitis: An Experimental Study Open
AIM: Norfloxacin (NFX) has low ocular bioavailability. The current work aimed to develop NFX-loaded nanoparticle (NP)-laden hydrogels to improve the ocular potential of NFX, minimize the need for frequent instillations and lower undesirabl…
Low density alfuzosin hydrochloride floating tablets: in vitro characterization and in vivo gastroretentive MRI tracking in healthy volunteers Open
The current work aimed to develop promising floating sustained release systems for alfuzosin hydrochloride (ALF) utilizing sublimation technique.Gastroretentive tablets were prepared by direct compression and subsequent sublimation of the …
Low-Frequency versus High-Frequency Ultrasound-Mediated Transdermal Delivery of Agomelatine-Loaded Invasomes: Development, Optimization and in-vivo Pharmacokinetic Assessment Open
I2-LFU-C4 is a promising transdermal system for AGM.
Ethosome-Derived Invasomes as a Potential Transdermal Delivery System for Vardenafil Hydrochloride: Development, Optimization and Application of Physiologically Based Pharmacokinetic Modeling in Adults and Geriatrics Open
ETH9-INV8 is a promising transdermal system for VRD.
Eudragit<sup>®</sup>-S100 Coated PLGA Nanoparticles for Colon Targeting of Etoricoxib: Optimization and Pharmacokinetic Assessments in Healthy Human Volunteers Open
E-M14C is a potential system for possible colon targeting of etoricoxib.
Spray-Dried Silica Xerogel Nanoparticles as a Promising Gastroretentive Carrier System for the Management of Chemotherapy-Induced Nausea and Vomiting Open
The prolongation in the mean residence time (MRT(0-∞)) and the promotion of the relative oral bioavailabilities of both drugs could unravel the potential of this system for the management of chemotherapy-induced nausea and vomiting.
Olmesartan medoxomil-loaded mixed micelles: Preparation, characterization and in-vitro evaluation Open
Olmesartan medoxomil (OLM) is highly lipophilic in nature (log p = 4.31) which attributes to its low aqueous solubility contributing to its low bioavailability 25.6%. OLM was loaded into mixed micelles carriers in a trial to enhance its so…
Duodenum-triggered delivery of pravastatin sodium: II. Design, appraisal and pharmacokinetic assessments of enteric surface-decorated nanocubosomal dispersions Open
The duodenum-triggering potential and the controlled-release characteristics of the best achieved system for smart PVS delivery were revealed.