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View article: Clinical Significance of HER2-low Expression in Triple-negative Breast Cancer: A Retrospective Multicenter Study.
Clinical Significance of HER2-low Expression in Triple-negative Breast Cancer: A Retrospective Multicenter Study. Open
Although the HER2-low and HER2-null tumor groups among TNBC showed no significant differences in response to neoadjuvant chemotherapy or patient outcomes, the higher proliferative activity and differing outcome trends in HER2-null tumors s…
View article: Evaluation of aluminum surface factors affecting the adhesive strength of epoxy adhesives
Evaluation of aluminum surface factors affecting the adhesive strength of epoxy adhesives Open
View article: Solute Distribution of α-Al Dendrite in Al–Si and Al–Cu Binary Aluminum Alloys during Solidification and Cooling Process
Solute Distribution of α-Al Dendrite in Al–Si and Al–Cu Binary Aluminum Alloys during Solidification and Cooling Process Open
To elucidate the segregation behavior of solutes in Al–Si and Al–Cu binary alloys, specimens of several hypo-eutectic Al–Si alloys water-quenched at different stages of solidification or air-cooled from melt to room temperature were prepar…
View article: Tolerability and safety of real‑world use of pomalidomide in patients with relapsed/refractory multiple myeloma
Tolerability and safety of real‑world use of pomalidomide in patients with relapsed/refractory multiple myeloma Open
Pomalidomide (POM) is a second-generation immunomodulatory agent with proven efficacy in patients with relapsed/refractory multiple myeloma (RRMM) proven to be refractory to previous treatment with lenalidomide (LEN) and bortezomib. We her…
View article: Effect of the timing of discontinuation of last‑line chemotherapy on patient prognosis in advanced and recurrent gastric cancer
Effect of the timing of discontinuation of last‑line chemotherapy on patient prognosis in advanced and recurrent gastric cancer Open
The present study aimed to determine the effect of the timing of treatment discontinuation on the prognosis of patients with advanced and recurrent gastric cancer chemotherapy. Between July 2014 and March 2017, 127 patients who underwent c…
View article: Cost-effectiveness and safety of the molecular targeted drugs afatinib, gefitinib and erlotinib as first-line treatments for patients with advanced EGFR mutation-positive non-small-cell lung cancer
Cost-effectiveness and safety of the molecular targeted drugs afatinib, gefitinib and erlotinib as first-line treatments for patients with advanced EGFR mutation-positive non-small-cell lung cancer Open
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), including gefitinib, erlotinib and afatinib are standard first-line treatments for EGFR gene mutation-positive non-small cell lung cancer. The present study aimed to …
View article: Usefulness of a pharmacist outpatient service for S-1 adjuvant chemotherapy in patients with gastric cancer
Usefulness of a pharmacist outpatient service for S-1 adjuvant chemotherapy in patients with gastric cancer Open
S-1 adjuvant chemotherapy is an outpatient treatment for gastric cancer. To evaluate the role of the pharmacist outpatient service in increasing medication adherence and reducing adverse events associated with S-1, the present study retros…
View article: Comparing the cost-effectiveness of FOLFIRINOX, nab-paclitaxel plus gemcitabine, gemcitabine and S-1 for the treatment of metastatic pancreatic cancer
Comparing the cost-effectiveness of FOLFIRINOX, nab-paclitaxel plus gemcitabine, gemcitabine and S-1 for the treatment of metastatic pancreatic cancer Open
The recommended chemotherapy regimens for pancreatic cancer include the combination of 5-fluorouracil/leucovorin, oxaliplatin and irinotecan (FOLFIRINOX), nab-paclitaxel (nab-PTX) plus gemcitabine (GEM), GEM alone and tegafur/gimeracil/ote…
View article: Analysis of the incidence of tumor lysis syndrome in patients with hematological malignancies treated with rasburicase
Analysis of the incidence of tumor lysis syndrome in patients with hematological malignancies treated with rasburicase Open
The purpose of this study was to assess the incidence of tumor lysis syndrome (TLS) in patients with hematological malignancies treated with rasburicase, and to evaluate the dose and duration of rasburicase administration. A total of 52 pa…
View article: Pharmaco-economic analysis of adjuvant chemotherapy for stage II and III colorectal cancer
Pharmaco-economic analysis of adjuvant chemotherapy for stage II and III colorectal cancer Open
Comparison of the costs of capecitabine plus oxaliplatin (CapeOX) with that of FOLFOX6 (5-fluorouracil/leucovorin [LV] + oxaliplatin) as an adjuvant chemotherapy for stage II or III colorectal cancer has previously been reported. However, …
View article: Comparison of cost-effectiveness of regorafenib and trifluridine/tipiracil combination tablet for treating advanced and recurrent colorectal cancer
Comparison of cost-effectiveness of regorafenib and trifluridine/tipiracil combination tablet for treating advanced and recurrent colorectal cancer Open
Regorafenib and trifluridine/tipiracil combination tablet regimens are standard third-line or later treatments for advanced and recurrent colorectal cancer with no significant difference in efficacy. The present study aimed to compare the …
View article: Neutropenia as a prognostic factor and safety of second-line therapy with S-1 for advanced or recurrent pancreatic cancer
Neutropenia as a prognostic factor and safety of second-line therapy with S-1 for advanced or recurrent pancreatic cancer Open
The aim of this retrospective study was to investigate the safety of S-1 as second-line therapy and to evaluate the association between neutropenia occurring during first-line gemcitabine (GEM) therapy and survival for advanced or recurren…
View article: Chemotherapy continuity and incidence of febrile neutropenia with CHOP therapy in an outpatient setting
Chemotherapy continuity and incidence of febrile neutropenia with CHOP therapy in an outpatient setting Open
The cyclophosphamide, doxorubicin, vincristine and prednisolone (CHOP) regimen is considered to be a standard treatment for non-Hodgkin's lymphoma (NHL). Patients receiving CHOP chemotherapy often experience febrile neutropenia (FN) due to…
View article: Analysis of the Risk Factors for Onset of Proteinuria with Bevacizumab Administration and the Effect of Renin-angiotensin System Depressant Drugs
Analysis of the Risk Factors for Onset of Proteinuria with Bevacizumab Administration and the Effect of Renin-angiotensin System Depressant Drugs Open
We examined risk factors for the onset of proteinuria with the bevacizumab (Bmab) administration, change in blood pressure, and the ratio of onset of proteinuria according to the type of combination of antihypertensive medications of the p…
View article: Adherence and awareness of the therapeutic intent of oral anticancer agents in an outpatient setting
Adherence and awareness of the therapeutic intent of oral anticancer agents in an outpatient setting Open
The aim of the present study was to clarify the adherence and awareness of oral anticancer agents by type and therapeutic purpose in outpatients prescribed with tegafur/gimeracil/oteracil potassium (S-1) or capecitabine. Outpatients underg…